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NMDA Receptors in the Basolateral Amygdala Complex Are Engaged for Pavlovian Fear Conditioning When an Animal's Predictions about Danger Are in Error

Authors: Tuval Keidar


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Description

It is widely accepted that Pavlovian fear conditioning requires activation of NMDA receptors (NMDARs) in the basolateral amygdala complex (BLA). However, it was recently shown that activation of NMDAR in the BLA is only required for fear conditioning when danger occurs unexpectedly; it is not required for fear conditioning when danger occurs as expected. This study tested the hypothesis that NMDARs in the BLA are engaged for Pavlovian fear conditioning when an animal's predictions regarding...

Keywords: NMDA receptorbasolateral amygdalafear conditioninghigher-order conditioningprediction errorrat


Links

PubMed: https://pubmed.ncbi.nlm.nih.gov/37607821/

DOI: 10.1523/JNEUROSCI.0067-23.2023