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In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis

Author(s): Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS;

Given the recent deployment of nerve agents as a method of warfare and in targeted assassinations, the development of robust, broad-spectrum medical countermeasures is essential. Our research group has synthesized isatin-pyridine oxime hybrids that have previously demonstrated the ability to resc ...

Article GUID: 40516590


Ultrasound and MRI-based evaluation of relationships between morphological and mechanical properties of the lower lumbar multifidus muscle in chronic low back pain

Author(s): Naghdi N; Masi S; Bertrand C; Rosenstein B; Cohen-Adad J; Rivaz H; Roy M; Fortin M;

Purposes: While lumbar multifidus (MF) muscle alterations are linked to low back pain (LBP), the structure-function relationship is not fully understood. This study aims to evaluate the relationship between fatty degeneration of the lumbar MF muscle and its function in individuals with and without LBP. Methods: The study included 25 participants with chr ...

Article GUID: 40488869


What is the role of non-surgical clinicians in the assessment and management of degenerative cervical myelopathy? - Insights from the RECODE-DCM peri-operative rehabilitation incubator

Author(s): Chauhan RV; Demetriades AK; Boerger TF; Lantz JM; Treanor C; Kalsi-Ryan S; Kumar V; Wood L; Plener J; Wilson N; Fortin M; Ammendolia C; Paus A; Dhillon RS; Davies B; Fehlings MG; Anderson DB;

Introduction: Evidence on degenerative cervical myelopathy (DCM) has frequently focussed on surgical management, overlooking the role of non-surgical clinicians. Their contributions in the patient journey remain largely underexplored in the literature. Research question: What is the role of non- ...

Article GUID: 40487873


Leading the way to a safer workplace: What enables supervisors to be servant leaders and enhance subordinates workplace safety behaviors?

Author(s): Chen YP; Hsu YS; Panaccio A; Wang H;

Introduction: Drawing on the Motivation-Ability-Opportunity (MAO) framework and social information processing (SIP) theory, we hypothesized that supervisors demonstrate the highest level of servant leadership when their prosocial motivation (motivation), perspective taking (ability), and perceived collaborative-based HR configuration (opportunity) are all ...

Article GUID: 40483067


A practical approach for preventing dispersion of infection disease in naturally ventilated room

Author(s): Ren C; Cao SJ; Haghighat F;

During the ongoing COVID-19 pandemic period, the airborne transmission of viruses has raised widespread concern as daily activities are resumed in public buildings. It is essential to develop mitigation strategies of infection disease transmission (e.g., increase of ventilation rate) in different scenarios to reduce the infection risk. For classrooms in s ...

Article GUID: 40477856


Trilingual families language strategies: potential predictors and effect on trilingual exposure

Author(s): Quirk E; Hadeed N; Byers-Heinlein K;

Family language strategies are approaches that parents adopt for language use with their multilingual children. In bilingual contexts, these strategies influence children's language exposure and development (Macleod et al., 2022). In the more complex context of trilingualism, how families settle on strategies and their relationship with exposure may d ...

Article GUID: 40443954


Distributed adaptive sliding mode control with deep recurrent neural network for cooperative robotic system in automated fiber placement

Author(s): Zhu N; Xie WF;

In this article, a distributed control strategy using an adaptive sliding mode controller (ASMC) is proposed for a 13-degree-of-freedom (13-DOF) cooperative robotic system in the field of automated fiber placement (AFP). A distributed control structure with event-triggered mechanism is developed to guarantee the desired cooperation performance and reduce ...

Article GUID: 40436653


Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519


The enterobactin biosynthetic intermediate 2,3-dihydroxybenzoic acid is a competitive inhibitor of the Escherichia coli isochorismatase EntB

Author(s): Bin X; Pawelek PD;

The Escherichia coli enterobactin biosynthetic protein EntB is a bifunctional enzyme that catalyzes hydrolysis of isochorismate via its N-terminal isochorismatase (IC) domain, and then transfers phosphopantetheinylated 2,3-DHB to EntF via the EntB C-terminal aryl carrier protein (ArCP) domain. Here we used a fluorescence anisotropy binding assay to invest ...

Article GUID: 40400396


NIRSTORM: a Brainstorm extension dedicated to functional near-infrared spectroscopy data analysis, advanced 3D reconstructions, and optimal probe design

Author(s): Delaire É; Vincent T; Cai Z; Machado A; Hugueville L; Schwartz D; Tadel F; Cassani R; Bherer L; Lina JM; Pélégrini-Issac M; Grova C;

Significance: Understanding the brain's complex functions requires multimodal approaches that combine data from various neuroimaging techniques. Functional near-infrared spectroscopy (fNIRS) offers valuable insights into hemodynamic responses, complementing other modalities such as electroenc ...

Article GUID: 40375973


Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear-Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes

Author(s): Pinto SM; Cheung JPY; Samartzis D; Karppinen J; Zheng YP; Pang MYC; Fortin M; Wong AYL;

Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as pain and disability) after considering confounders (spinal phenotypes, fear-avoidance beliefs [FABs] and insomnia). This study examined: ...

Article GUID: 40376565


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