Author(s): Yousefi R; Panahi Moghaddam SA; Salahi H; Woods R; Abolhasani M; Eini-Zinab H; Saidpour A;
Obesity is associated with maladaptive eating behaviors, including food addiction (FA) and binge eating disorder (BED). However, the key factors influencing the development of maladaptive eating behaviors remain unknown. Adherence to specified dietary patterns has been suspected of making indirec ...
Article GUID: 35975474
Author(s): Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT;
We present deep learning-based approaches for exploring the complex array of morphologies exhibited by the opportunistic human pathogen Candida albicans. Our system, entitled Candescence, automatically detects C. albicans cells from differential image contrast microscopy and labels each detected ...
Article GUID: 35972285
Author(s): Ouellette S; Pakarian P; Bin X; Pawelek PD;
Siderophores are high-affinity small-molecule chelators employed by bacteria to acquire iron from the extracellular environment. The Gram-negative bacterium Escherichia coli synthesizes and secretes enterobactin, a tris-catechol siderophore. Enterobactin is synthesized by six cytoplasmic enzyme activities: EntC, EntB (isochorismatase (IC) domain), EntA, E ...
Article GUID: 35952947
Author(s): Uthamacumaran A; Zenil H;
Cancers are complex adaptive diseases regulated by the nonlinear feedback systems between genetic instabilities, environmental signals, cellular protein flows, and gene regulatory networks. Understanding the cybernetics of cancer requires the integration of information dynamics across multidimensional spatiotemporal scales, including genetic, transcriptio ...
Article GUID: 35957879
Author(s): Londoño-Berrío M; Pérez-Buitrago S; Ortiz-Trujillo IC; Hoyos-Palacio LM; Orozco LY; López L; Zárate-Triviño DG; Capobianco JA; Mena-Giraldo P;
Drug nanoencapsulation increases the availability, pharmacokinetics, and concentration efficiency for therapeutic regimes. Azobenzene light-responsive molecules experience a hydrophobicity change from a polar to an apolar tendency by trans-cis photoisomerization upon UV irradiation. Polymeric pho ...
Article GUID: 35956634
Author(s): Lacasse JM; Gomez-Perales E; Brake WG;
Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations regard ...
Article GUID: 35952797
Author(s): Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S;
Rational: Stress is a major trigger for drug relapse in humans and animal models, even after prolonged abstinence. However, animal models for stress-induced relapse were criticized for the lack of predictive and face validity.
Objectives: Here we investigated the effect of acute food deprivation stress in a novel str ...
Article GUID: 35951079
Author(s): Saillant K; Intzandt B; Bérubé B; Sanami S; Gauthier C; Bherer L;
Background: Physical inactivity significantly increases risk of cardiovascular diseases, which are highly prevalent in aging. Conversely, higher levels of physical activity in aging have been associated with benefits for physical and cognitive health and is hypothesized to prevent and reduce development of cardiovascular risk factors. However, those older ...
Article GUID: 35950796
Author(s): De Visscher A; Pinheiro Patrício PC;
Chemical engineering involves a skill set that is transferrable to a broad range of other areas. A case in point is the work that is being done by chemical engineers to better understand and fight the COVID-19 epidemic. In this study, we consider a problem that has eluded the COVID-19 research community, which is nevertheless very tractable with a chemica ...
Article GUID: 35942051
Author(s): Samlali K; Thornbury M; Venter A;
Direct-to-consumer (DTC) genetic testing is cheaper and more accessible than ever before. What is generally hidden from the consumer is the intention to combine, reuse, and resell this genetic information as powerful datasets. This financial gain is creating a competitive DTC market, reducing the price of whole genome sequencing (WGS) down to USD 299. Ent ...
Article GUID: 35939839
Author(s): Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA;
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. Reductions in estrogens may alter cognition by reducing the function of cholinergic inputs to both the hippocampus and entorhinal cortex. In ...
Article GUID: 35939438
Author(s): Leonov A; Feldman R; Piano A; Arlia-Ciommo A; Junio JAB; Orfanos E; Tafakori T; Lutchman V; Mohammad K; Elsaser S; Orfali S; Rajen H; Titorenko VI;
We propose a hypothesis of a mechanism linking cellular aging to cellular quiescence in chronologically aging budding yeast. Our hypothesis posits that this mechanism integrates four different processes, all of which are initiated after yeast cells cultured in a medium initially containing glucos ...
Article GUID: 35937500
