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Calcium activity is a degraded estimate of spikes

Author(s): Hart EE; Gardner MPH; Panayi MC; Kahnt T; Schoenbaum G;

Recording action potentials extracellularly during behavior has led to fundamental discoveries regarding neural function-hippocampal neurons respond to locations in space,1 motor cortex neurons encode movement direction,2 and dopamine neurons signal reward prediction errors3-observations undergirding current theories of cognition,4 movement,5 and learning ...

Article GUID: 36368324


A Synthetic Biosensor for Detecting Putrescine in Beef Samples

Author(s): Selim AS; Perry JM; Nasr MA; Pimprikar JM; Shih SCC;

Biogenic amines (BAs) are toxicological risks present in many food products. Putrescine is the most common foodborne BA and is frequently used as a quality control marker. Currently, there is a lack of regulation concerning safe putrescine limits in food as well as outdated food handling practices leading to unnecessary putrescine intake. Conventional met ...

Article GUID: 36356104


Cancer Survivors' Evolving Perceptions of a New Supportive Virtual Program

Author(s): Robb A; Brown TL; Durand A; Loiselle CG;

This qualitative study begins to explore cancer survivors' evolving perceptions of "Focus on the Future," a 6-week supportive virtual program led by trained volunteers and health care professionals. Through purposive sampling, participants (n = 10) enrolled in the program were individually interviewed shortly before attending, mid-way through, and at ...

Article GUID: 36354724


An experimental and modeling study on the penetration of spilled oil into thawing frozen soil

Author(s): Qu Z; An C; Mei Z; Yue R; Zhao S; Feng Q; Cai M; Wen J;

Oil spills are significant environmental accidents that have significant impacts on environmental and ecological health. Spill pollution in the cold regions may pose a particular challenge. To achieve a fast response, the oil transport mode such as penetration should be well understood. In this study, the oil penetration behavior in thawing frozen soil at ...

Article GUID: 36349394


Patient and family engagement in patient care and research in Canadian intensive care units: a national survey

Author(s): Burns KEA; McDonald E; Debigaré S; Zamir N; Vasquez M; Piche-Ayotte M; Oczkowski S;

Purpose: While patient and family engagement may improve clinical care and research, current practices for engagement in Canadian intensive care units (ICUs) are unknown. Methods: We developed and administered a cross-sectional questionnaire to ICU leaders of current engagement practices, facilitators, and barriers to engagement, and whether engagement w ...

Article GUID: 36344874


Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2022 update

Author(s): Jain R; Stone JA; Agarwal G; Andrade JG; Bacon SL; Bajaj HS; Baker B; Cheng G; Dannenbaum D; Gelfer M; Habert J; Hickey J; Keshavjee K; Kitty D; Lindsay P; L' Abbé MR; Lau DCW; Macle L; McDonald M; Nerenberg K; Pearson GJ; Pham T; Poppe AY; Rabi DM; Sherifali D; Selby P; Smith E; Stern S; Th ...

No abstract

Article GUID: 36343954


Cerebral blood flow in schizophrenia: A systematic review and meta-analysis of MRI-based studies

Author(s): Percie du Sert O; Unrau J; Gauthier CJ; Chakravarty M; Malla A; Lepage M; Raucher-Chéné D;

Introduction: Schizophrenia-spectrum disorders (SSD) represent one of the leading causes of disability worldwide and are usually underpinned by neurodevelopmental brain abnormalities observed on a structural and functional level. Nuclear medicine imaging studies of cerebral blood ...

Article GUID: 36341843


Social Interaction Profiles Among Youth with Intellectual Disabilities: Associations with Indicators of Psychosocial Adjustment

Author(s): Dubé C; Morin AJS; Tóth-Király I; Olivier E; Tracey D; McCune VS; Craven RG; Maïano C;

This study investigates the nature of the social interaction profiles observed among youth with intellectual disabilities (ID), defined while considering their relationships with their parents, peers, and teachers, as well as the implication of these profiles for self-esteem, aggressive behaviors, and prosocial behaviors. A sample of 393 youth with mild ( ...

Article GUID: 36342629


A resistome survey across hundreds of freshwater bacterial communities reveals the impacts of veterinary and human antibiotics use

Author(s): Kraemer SA; Barbosa da Costa N; Oliva A; Huot Y; Walsh DA;

Our decreasing ability to fight bacterial infections is a major health concern. It is arising due to the evolution of antimicrobial resistance (AMR) in response to the mis- and overuse of antibiotics in both human and veterinary medicine. Lakes integrate watershed processes and thus may act as receptors and reservoirs of antibiotic resistance genes (ARGs) ...

Article GUID: 36338036


Who's cooking tonight? A time-use study of coupled adults in Toronto, Canada

Author(s): Liu B; Widener MJ; Smith LG; Farber S; Gesink D; Minaker LM; Patterson Z; Larsen K; Gilliland J;

Understanding how coupled adults arrange food-related labor in relation to their daily time allocation is of great importance because different arrangements may have implications for diet-related health and gender equity. Studies from the time-use perspective argue that daily activities such as w ...

Article GUID: 36339032


The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression

Author(s): Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD;

Background: Adaptive behavior depends on the delicate and dynamic balance between acquisition and extinction memories. Disruption of this balance, particularly when the extinction of memory loses control over behavior, is the root of treatment failure of maladaptive behaviors such as substance abuse or anxiety disorders. Understanding this balance require ...

Article GUID: 36336498


Combining elements of the CO-OP Approach™ with education to promote healthy eating among older adults: A pilot study

Author(s): Dawson DR; Bar Y; Ajwani F; Rotenberg S; Atlas B; Ricupero M; Greewood C; Parrott MD;

This paper describes an exploratory study developing the Baycrest Brain-healthy Eating Approach (BBEA). Poor diet is a modifiable risk factor for many health problems including dementia. Mediterranean type diets, high in plant-based foods, rich in poly- and mono- unsaturated fatty acids with minimal consumption of saturated fat, red meat, and processed fo ...

Article GUID: 36338514


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