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Combined effects of the contraceptive hormones, ethinyl estradiol and levonorgestrel, on the use of place and response memory in gonadally-intact female rats

Author(s): Lacasse JM; Boulos V; Fisher C; Hamilton S; Heron M; Mac Cionnaith CE; Peronace V; Tito N; Brake WG;

During maze navigation rats can rely on hippocampus-mediated place memory or striatum-mediated response memory. Ovarian hormones bias whether females use place or response memory to reach a reward. Here, we investigated the impact of the contraceptive hormones, ethinyl estradiol (EE) and levonorg ...

Article GUID: 36403510


Multiple routes to help you roam: A comparison of training interventions to improve cognitive-motor dual-tasking in healthy older adults

Author(s): Downey R; Bherer L; Pothier K; Vrinceanu T; Intzandt B; Berryman N; Lussier M; Vincent T; Karelis AD; Nigam A; Vu TTM; Bosquet L; Li KZH;

Cognitive-motor dual-tasking is a complex activity that predicts falls risk and cognitive impairment in older adults. Cognitive and physical training can both lead to improvements in dual-tasking; however, less is known about what mechanisms underlie these changes. To investigate this, 33 healthy ...

Article GUID: 36408116


Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice

Author(s): Roque PS; Thörn Perez C; Hooshmandi M; Wong C; Eslamizade MJ; Heshmati S; Brown N; Sharma V; Lister KC; Goyon VM; Neagu-Lund L; Shen C; Daccache N; Sato H; Sato T; Mogil JS; Nader K; Gkogkas CG; Iordanova MD; Prager-Khoutorsky M; McBride ...

Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly understood. Here, we show that repeated genera ...

Article GUID: 36394958


Motion estimation for large displacements and deformations

Author(s): Chen Q; Poullis C;

Large displacement optical flow is an integral part of many computer vision tasks. Variational optical flow techniques based on a coarse-to-fine scheme interpolate sparse matches and locally optimize an energy model conditioned on colour, gradient and smoothness, making them sensitive to noise in the sparse matches, deformations, and arbitrarily large dis ...

Article GUID: 36385172


Sex-Linked Biology and Gender-Related Research Is Essential to Advancing Hearing Health

Author(s): Reavis KM; Bisgaard N; Canlon B; Dubno JR; Frisina RD; Hertzano R; Humes LE; Mick P; Phillips NA; Pichora-Fuller MK; Shuster B; Singh G;

There is robust evidence that sex (biological) and gender (behavioral/social) differences influence hearing loss risk and outcomes. These differences are noted for animals and humans-in the occurrence of hearing loss, hearing loss progression, and response to interventions. Nevertheless, many stu ...

Article GUID: 36384870


Rosemary essential oil and its components 1,8-cineole and α-pinene induce ROS-dependent lethality and ROS-independent virulence inhibition in Candida albicans

Author(s): Shahina Z; Al Homsi R; Price JDW; Whiteway M; Sultana T; Dahms TES;

The essential oil from Rosmarinus officinalis L., a composite mixture of plant-derived secondary metabolites, exhibits antifungal activity against virulent candidal species. Here we report the impact of rosemary oil and two of its components, the monoterpene a-pinene and the monoterpenoid 1,8-cineole, against Candida albicans, which induce ROS-dependent c ...

Article GUID: 36383525


Reinforcement learning for automatic quadrilateral mesh generation: A soft actor-critic approach

Author(s): Pan J; Huang J; Cheng G; Zeng Y;

This paper proposes, implements, and evaluates a reinforcement learning (RL)-based computational framework for automatic mesh generation. Mesh generation plays a fundamental role in numerical simulations in the area of computer aided design and engineering (CAD/E). It is identified as one of the critical issues in the NASA CFD Vision 2030 Study. Existing ...

Article GUID: 36375347


An RNA granule for translation quality control in Saccharomyces cerevisiae

Author(s): Dhaliwal JS; Panozzo C; Benard L; Zerges W;

Cytoplasmic RNA granules compartmentalize phases of the translation cycle in eukaryotes. We previously reported the localization of oxidized RNA to cytoplasmic foci called oxidized RNA bodies (ORBs) in human cells. We show here that ORBs are RNA granules in Saccharomyces cerevisiae. Several lines of evidence support a role of ORBs in the compartmentalizat ...

Article GUID: 36373798


Green building standards and the United Nations' Sustainable Development Goals

Author(s): Goubran S; Walker T; Cucuzzella C; Schwartz T;

Sustainable practices in the building industry are strongly influenced by published green and sustainable building and real-estate standards (GSBRES). Therefore, it is crucial to assess how these standards contribute to achieving the United Nations' Sustainable Development Goals (SDGs). This paper evaluates the extent to which GSBRESs align with the 2 ...

Article GUID: 36372039


Insights on the COVID-19 pandemic: Youth engagement through photovoice

Author(s): Pickering CJ; Al-Baldawi Z; McVean L; Adan M; Amany RA; Al-Baldawi Z; Baker L; O' Sullivan T;

Youth engagement in disaster risk reduction is a growing area of research, practice and policy. The COVID-19 pandemic highlighted the need for improved opportunities for youth to participate and have their voices heard. Our Photovoice study explores experiences, perceptions, and insights of youth ...

Article GUID: 36373152


Optogenetic stimulation of infralimbic cortex projections to the paraventricular thalamus attenuates context-induced renewal

Author(s): Brown A; Chaudhri N;

Contexts associated with prior reinforcement can renew extinguished conditioned responding. The prelimbic (PL) and infralimbic (IL) cortices are thought to mediate the expression and suppression of conditioned responding, respectively. Evidence suggests that PL inputs to the paraventricular nucleus of the thalamus (PVT) drive the expression of cue-induced ...

Article GUID: 36373226


Calcium activity is a degraded estimate of spikes

Author(s): Hart EE; Gardner MPH; Panayi MC; Kahnt T; Schoenbaum G;

Recording action potentials extracellularly during behavior has led to fundamental discoveries regarding neural function-hippocampal neurons respond to locations in space,1 motor cortex neurons encode movement direction,2 and dopamine neurons signal reward prediction errors3-observations undergirding current theories of cognition,4 movement,5 and learning ...

Article GUID: 36368324


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