1 School of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran.
2 School of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran. pezeshk@ut.ac.ir.
3 School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran. pezeshk@ut.ac.ir.
4 Department of Mathematics and Statistics, Concordia University, Montreal, Canada. pezeshk@ut.ac.ir.
5 National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Currently a few tools are capable of detecting genome-wide Copy Number Variations (CNVs) based on sequencing of multiple samples. Although aberrations in mate pair insertion sizes provide additional hints for the CNV detection based on multiple samples, the majority of the current tools rely only on the depth of coverage. Here, we propose a new algorithm (MSeq-CNV) which allows detecting common CNVs across multiple samples. MSeq-CNV applies a mixture density for modeling aberrations in depth of coverage and abnormalities in the mate pair insertion sizes. Each component in this mixture density applies a Binomial distribution for modeling the number of mate pairs with aberration in the insertion size and also a Poisson distribution for emitting the read counts, in each genomic position. MSeq-CNV is applied on simulated data and also on real data of six HapMap individuals with high-coverage sequencing, in 1000 Genomes Project. These individuals include a CEU trio of European ancestry and a YRI trio of Nigerian ethnicity. Ancestry of these individuals is studied by clustering the identified CNVs. MSeq-CNV is also applied for detecting CNVs in two samples with low-coverage sequencing in 1000 Genomes Project and six samples form the Simons Genome Diversity Project.