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Inter-protein residue covariation information unravels physically interacting protein dimers

Author(s): Salmanian S; Pezeshk H; Sadeghi M;

Background: Predicting physical interaction between proteins is one of the greatest challenges in computational biology. There are considerable various protein interactions and a huge number of protein sequences and synthetic peptides with unknown interacting counterparts. Most of co-evolutionary methods discover a combination of physical interplays and f ...

Article GUID: 33334319


MSeq-CNV: accurate detection of Copy Number Variation from Sequencing of Multiple samples

Author(s): Malekpour SA; Pezeshk H; Sadeghi M;

Currently a few tools are capable of detecting genome-wide Copy Number Variations (CNVs) based on sequencing of multiple samples. Although aberrations in mate pair insertion sizes provide additional hints for the CNV detection based on multiple samples, the majority of the current tools rely only on the depth of coverage. Here, we propose a new algorithm ...

Article GUID: 29507384


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