Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients
Authors: Pellegrino G, Xu M, Alkuwaiti A, Porras-Bettancourt M, Abbas G, Lina JM, Grova C, Kobayashi E
Affiliations
1 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
2 Department of Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, China.
3 Multimodal Functional Imaging Laboratory, Biomedical Engineering Department, McGill University, Montreal, QC, Canada.
4 Département de Génie Électrique, École de Technologie Supérieure, Montreal, QC, Canada.
5 Centre de Recherches Mathematiques, Univeristé de Montréal, Montreal, QC, Canada.
6 Physics Department and PERFORM Centre, Concordia University, Montreal, QC, Canada.
Description
Objective: Magnetoencephalography source imaging (MSI) of interictal epileptiform discharges (IED) is a useful presurgical tool in the evaluation of drug-resistant frontal lobe epilepsy (FLE) patients. Yet, failures in MSI can arise related to artifacts and to interference of background activity. Independent component analysis (ICA) is a popular denoising procedure but its clinical application remains challenging, as the selection of multiple independent components (IC) is controversial,...
Keywords: MEG; frontal epilepsy; independent component analysis; interictal epileptiform discharges; magnetic source imaging; magnetoencephalography; source localization; spike;
Links
PubMed: https://pubmed.ncbi.nlm.nih.gov/32582009/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1deGMjvjVspk9gsE
DOI: 10.3389/fneur.2020.00479
