Authors: Santosa S, Bush NC, Jensen MD
Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.
J Clin Endocrinol Metab. 2017 08 01;102(8):3056-3064
Authors: Santosa S, Bush NC, Jensen MD
Abstract
Context: Although the long-term effects of testosterone on adipose tissue lipid metabolism in men have been defined, the short-term regulation of these effects is not well understood.
Objective: We examined the effects of acute testosterone withdrawal on subcutaneous abdominal and femoral adipose tissue fatty acid (FA) storage and cellular mechanisms.
Design: This was a prospective, randomized trial.
Setting: Mayo Clinic Clinical Research Unit.
Patients or Participants: Thirty-two male volunteers ages 18 to 50 participated in these studies.
Interventions: Volunteers were randomized to receive (1) no treatment (control), (2) injections (7.5 mg) of LupronĀ®, or (3) Lupron and testosterone (L+T) replacement for 49 days, resulting in 4 weeks of sex steroid suppression in the Lupron group.
Main Outcome Measures: We measured body composition, fat cell size, adipose tissue meal FA and direct free FA storage, lipoprotein lipase (LPL), acyl coenzyme A synthetase (ACS), diacylglycerol acyltransferase activities, and CD36 content.
Results: Compared with control and L+T groups, acute testosterone deficiency resulted in greater femoral adipose tissue meal FA storage rates, fasting and fed LPL activity, and ACS activity.
Conclusions: These results suggest that in men, testosterone plays a tonic role in restraining FA storage in femoral adipose tissue via suppression of LPL and ACS activities. FA storage mechanisms in men appear sensitive to short-term changes in testosterone concentrations.
PMID: 28641384 [PubMed - indexed for MEDLINE]
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28641384?dopt=Abstract