PERFORM Publications

Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus

Author(s): Plissonneau C; Santosa S;

The excessive accumulation of adipose tissue in obesity appears to result in adipose tissue dysfunction perpetuating the onset of obesity-related diseases, including type 2 diabetes (T2DM). In humans, adipose tissue is stored in several depots including subcutaneous and visceral. These depots contribute to the pathology of obesity differently owing to dif ...

Article GUID: 39553621

Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region

Author(s): Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S;

Objective: We aimed to examine the effect of age of obesity onset, sex, and their interaction on abdominal and femoral subcutaneous adipose tissue (SAT) morphology (degree of adipocyte hyperplasia or hypertrophy). Methods: In this cross-sectional study, we isolated adipocytes via collagenase dig ...

Article GUID: 39045668

Compensatory health motivations and behaviors scale: Development, evaluation, psychometric properties and a preliminary validation

Author(s): Sedemedes K; Knäuper B; Sadikaj G; Yuan TY; Wrosch C; Santosa S; Alberga AS; Kakinami L;

The "Compensatory Health Beliefs" scale assesses the degree to which one believes that unhealthy behaviours can be compensated through healthier ones. However, no validated scale to assess compensatory weight-related behaviors exists. The study's objective was to develop (Study 1) and validate (Study 2) a questionnaire measuring compensatory health mo ...

Article GUID: 37804879

Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss

Author(s): Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S;

Objective: The aim of this study was to determine the effect of age of obesity onset on senescence-related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and after moderate (~10%) weight loss. Methods: AB and FEM SAT were collected from human females with ch ...

Article GUID: 37194560

Understanding the impact of radical changes in diet and the gut microbiota on brain function and structure: rationale and design of the EMBRACE study

Author(s): Ben-Porat T; Alberga A; Audet MC; Belleville S; Cohen TR; Garneau PY; Lavoie KL; Marion P; Mellah S; Pescarus R; Rahme E; Santosa S; Studer AS; Vuckovic D; Woods R; Yousefi R; Bacon SL;

Background: Bariatric surgery leads to profound changes in gut microbiota and dietary patterns, both of which may interact to impact gut-brain communication. Though cognitive function improves postsurgery, there is a large variability in outcomes. How bariatric surgery-induced modifications in th ...

Article GUID: 37088645

Body-composition phenotypes and their associations with cardiometabolic risks and health behaviours in a representative general US sample

Author(s): Kakinami L; Plummer S; Cohen TR; Santosa S; Murphy J;

Body mass index is poor at distinguishing between adiposity and muscle. Based on dual energy X-ray absorptiometry data, a diagnostic framework to analyze body composition by categorizing fat- and muscle-mass body composition into four phenotypes has been proposed. The objective of this study was to assess the association between body-composition phenotype ...

Article GUID: 36183799

Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity

Author(s): Turner L; Gauthier MF; Lafortune A; Tchernof A; Santosa S;

Background: The timing of obesity onset and age have been shown to affect the risk of obesity-related comorbidities, although the impact of each of these factors on markers of adipose tissue function remains unclear. Objective: The aim of this study was to determine whether differences in regional adipose tissue characteristics vary with age and age of o ...

Article GUID: 35927468

Editorial: The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome

Author(s): Elisia I; Santosa S; Popovich DG; Krystal G;

No abstract

Article GUID: 35237644

Assessing the Contribution of Traditional Foods to Food Security for the Wapekeka First Nation of Canada

Author(s): Robidoux MA; Winnepetonga D; Santosa S; Haman F;

The food security crisis and disproportionately high burden of dietary related disease amongst northern Indigenous populations in Canada continues to be a troubling reality with little sign of improvement. The Government of Canada is responding by developing programs to support local food initiatives for northern isolated communities. While such investmen ...

Article GUID: 34310881

Adiposity and muscle mass phenotyping is not superior to BMI in detecting cardiometabolic risk in a cross-sectional study

Author(s): Kakinami L; Danieles PK; Ajibade K; Santosa S; Murphy J;

Objective: Classifying adiposity based on dual-energy x-ray absorptiometry (DXA) muscle and fat mass phenotypes has been proposed. Whether these phenotypes are more accurate in predicting cardiometabolic risk than BMI weight status is unknown. Methods: Data were from the National Health and Nutrition Examination Survey (NHANES; 1999-2006 cycles, n = 5,47 ...

Article GUID: 34231966

Editorial: Advances in Dietary Fat Absorption

Author(s): Nauli AM; Santosa S; Dixon JB;