1 Department of Chemistry, McGill University 801 Sherbrooke St. West Montreal QC H3A 0B8 Canada tomislav.friscic@mcgill.ca.
2 Department of Chemistry and Biochemistry, Concordia University Montreal QC Canada.
3 Genentech One Dna Way South San Francisco CA 94080 USA.

We present a rapid and readily scalable methodology for the mechanosynthesis of diverse metal-organic frameworks (MOFs) in the absence of milling media typically required for other types of mechanochemical syntheses. We demonstrate the use of liquid-assisted resonant acoustic mixing (LA-RAM) methodology for the synthesis of three- and two-dimensional MOFs based on Zn(ii), Co(ii) and Cu(ii), including a mixed ligand system. Importantly, the LA-RAM approach also allowed the synthesis of the ZIF-L framework that has never been previously obtained in a mechanochemical environment, as well as its Co(ii) analogue. Straightforward scale-up from milligrams to at least 25 grams is demonstrated using the metastable framework ZIF-L as the model.