Author(s): Rabouhi N; Guindon S; Coleman EA; van Heesbeen HJ; Greenwood CMT; Lu T; Campeau PM;

Chromodomain Helicase DNA-binding (CHD) proteins compose a family of chromatin remodelers that play crucial roles in DNA repair and gene expression regulation, neural stem cell differentiation and chromatin integrity. Genetic variants in CHD chromatin remodelers are associated with neurodevelopmental disorders with features like autism spectrum disorder a ...

Article GUID: 40907936

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317

Author(s): AlHammad K; Medraj M; Tembely M;

Water droplet erosion (WDE) is a critical degradation phenomenon that significantly affects component lifespan and performance in power generation, aerospace, and wind energy industries. The incubation period-the initial phase before visible material loss occurs-is particularly crucial for maintenance planning and material selection yet remains challengin ...

Article GUID: 40612685

Author(s): Wang X; Sedaghati R; Rakheja S; Shangguan W;

Rubber materials can endure substantial deformation while avoiding permanent damage or rupture, making them highly suitable for applications in the automotive industry and other sectors, particularly for noise and vibration reduction. However, rubber experiences degradation over time as defects or cracks appear and propagate under fluctuating loads. There ...

Article GUID: 40219307

Author(s): Bothe B; Tóth-Király I; Popova N; Nagy L; Koós M; Demetrovics Z; Potenza MN; Kraus SW; Ballester-Arnal R; Batthyány D; Bergeron S; Billieux J; Briken P; Burkauskas J; Cárdenas-López G; Carvalho J; Castro-Calvo J; Chen L; Ciocca G; Corazz ...

Background and aims: The Moral Incongruence Model of Pornography Use proposes that pornography-use-related problems may be present due to problematic pornography use (PPU) and/or moral disapproval (MD) of pornography use. Despite some supporting empirical evidence, no study has tested the presenc ...

Article GUID: 39945767

Author(s): Vatandoost H; Abdalaziz M; Sedaghati R; Rakheja S;

Magnetorheological (MR) fluid (MRF) dampers, serving as fail-safe semi-active devices, exhibit nonlinear hysteresis characteristics, emphasizing the necessity for accurate modeling to formulate effective control strategies in smart systems. This paper introduces a novel stop operator-based Prandtl-Ishlinskii (PI) model, featuring a reduced parameter set ( ...

Article GUID: 39867636

Author(s): Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M;

Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent. Methods: Young social drinkers (age 18.5 ± 0.6 y.o. ...

Article GUID: 39725679

Author(s): Abtahi M; Athienitis A; Delcroix B;

This paper presents a methodology to develop archetype gray-box models and use them in an economic model-based predictive control algorithm to simulate optimal heating load management in response to a newly-introduced static time-of-use tariff for Québec's residential sector, rate Flex-D. The methodology is evaluated through a case study, wherein in s ...

Article GUID: 39507415

Author(s): Wynes S; Davis SJ; Dickau M; Ly S; Maibach E; Rogelj J; Zickfeld K; Matthews HD;

The Intergovernmental Panel on Climate Change (IPCC) employs emission scenarios to explore a range of future climate outcomes but refrains from assigning probabilities to individual scenarios. However, IPCC authors have their own views on the likelihood of different climate outcomes, which are valuable to understand because authors possess both expert ins ...

Article GUID: 39280638

Author(s): Ara A; Provias V; Sitek K; Coffey EBJ; Zatorre RJ;

Perception integrates both sensory inputs and internal models of the environment. In the auditory domain, predictions play a critical role because of the temporal nature of sounds. However, the precise contribution of cortical and subcortical structures in these processes and their interaction remain unclear. It is also unclear whether these brain interac ...

Article GUID: 39087881

Author(s): Arseneau-Robar TJ; Teichroeb JA; Macintosh AJJ; Saj TL; Glotfelty E; Lucci S; Sicotte P; Wikberg EC;

Intergroup aggression often results in the production of public goods, such as a safe and stable social environment and a home range containing the resources required to survive and reproduce. We investigate temporal variation in intergroup aggression in a growing population of colobus monkeys (C ...

Article GUID: 38906888