Author(s): Saputra ST; Van Hulst A; Henderson M; Brugiapaglia S; Faustini C; Kakinami L;
Background: A dual-energy x-ray absorptiometry (DXA)-derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population. Methods: Children's (= 17 years) DXA data in NHANES (n = 6120) were used to generate sex- and age-specific deciles of appendicular skeletal muscle mass inde ...
Article GUID: 40878792
Author(s): Clermont-Paquette A; Fuoco G; Brancheriau CR; Piekny A; Naccache R;
The surface charge of carbon dots (CDs) governs cellular uptake; however, studies seldom compare CDs with similar physico-chemical properties thereby introducing confounding variables. Here, we investigate how the surface charge of amine-passivated carbon dots with similar optical and chemical properties influences their uptake in human cells. We synthesi ...
Article GUID: 40861971
Author(s): Karsten M; Gardenghi G; Arruda ACT; Catai AM; Vieira AM; Stein C; de Araujo CLP; Pereira DAG; Matte DL; da Silva FMF; Guimarães FS; Ghisi GLM; Chiappa GRS; Sbruzzi G; Cipriano GFB; Ribeiro GDS; Milani JGPO; Neves LMT; Calegari L; Morais ...
Background: Exercise training is a core component of cardiovascular rehabilitation programs for patients with heart failure (HF). In Brazil, physical therapists frequently deliver rehabilitation interventions. Given heart failure clinical management advancements and varied rehabilitation approach ...
Article GUID: 40857977
Author(s): Pelzer M; Ouellet-Courtois C; Krause S; Coughtrey A; Fink-Lamotte J;
Background: Perceiving a threat as constantly evolving, coming closer and escalating quickly can result in looming vulnerability (LV). LV may be a distal factor in contamination-based OCD (C-OCD) influencing disorder-specific mechanisms such as disgust. The aim of this study was to gain knowledge about three components of LV: speed, proximity and accelera ...
Article GUID: 40858003
Author(s): Sgro M; Reid ID; Arentshorst M; Ram AFJ; Tsang A;
Many microorganisms are able to use plant-derived aromatic and cyclic compounds like the common plant secondary metabolite quinic acid as carbon and energy sources. In fungi, three enzymatic steps convert quinic acid into the common intermediate protocatechuic acid, which is then further converted into TCA cycle intermediates. The genes encoding these thr ...
Article GUID: 40853219
Author(s): Semper C; Pham TTM; Ram S; Palys S; Evdokias G; Ouedraogo JP; Moisan MC; Geoffrion N; Reid I; Di Falco M; Bailey Z; Tsang A; Benoit-Gelber I; Savchenko A;
Genomics analysis confirmed the status of filamentous fungi as a rich source of novel secondary metabolites; however, the discovery of these compounds is hampered by the cryptic nature of their biosynthetic pathways under laboratory conditions. Consequently, despite substantial research effort ov ...
Article GUID: 40852424
Author(s): Abicumaran Uthamacumaran
Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...
Article GUID: 40848317
Author(s): Li Z; Chen R; Xing C; Zhong G; Zhang X; Jones KC; Zhu Y;
Organophosphate esters (OPEs) have emerged as a global environmental and health concern due to their persistent, bioaccumulative, and toxic (PBT) properties. Recently, their precursors-organophosphite antioxidants (OPAs)-and transformation products, which may exhibit greater persistence and toxicity, have gained attention as critical contributors to OPE-r ...
Article GUID: 40845576
Author(s): Yang Z; Chen Z; Lee K;
Amid growing concerns about oil spills in vulnerable Arctic and sub-Arctic regions driven by climate-induced ice retreat, this study presents the development and validation of the OSMT-ice model, an enhanced oil spill modeling system designed to predict the movement and fate of oil in ice-covered waters. The model incorporates ice-concentration-based (ICB ...
Article GUID: 40845360
Author(s): Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;
Patients with coronary artery disease (CAD) face an increased risk of cognitive impairment, dementia, and stroke. While white matter (WM) lesions are frequently reported in patients with CAD, the effects on WM microstructure alterations remain largely unknown. We aimed to identify WM microstructu ...
Article GUID: 40829939
Author(s): Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;
Introduction: Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modify adipose tissue immune cell composition, but whether these changes differ by obesity onset remains unknown. Method ...
Article GUID: 40831565
Author(s): Moore C; Donhauser PW; Klein D; Byers-Heinlein K;
The remarkable human capacity for bilingual and multilingual acquisition raises fundamental questions about how the brain develops efficient systems for processing multiple languages. In this study, we used neural network models trained on natural speech input to examine how these efficient representations emerge. Our models show that multiple phonologica ...
Article GUID: 40828024
