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Habitual napping in older adults is accompanied by altered heat-loss rhythms across the circadian cycle and reduced coupling between pre-sleep thermoregulatory dynamics and sleep initiation

Author(s): Dourte M; Hammad G; de Haan S; Deantoni M; Reyt M; Baillet M; Lesoinne A; Muto V; Collette F; Vandewalle G; Peigneux P; Cajochen C; Schmidt C;

Thermoregulatory processes are closely linked to sleep initiation and maintenance throughout the circadian cycle, and may contribute to the increased tendency to nap in older adults. This cross-sectional study examined whether habitual napping in healthy older individuals is associated with alter ...

Article GUID: 41797810


Trajectories of Alcohol-Related Problems Among First-Year Nursing Students: Nature, Predictors, and Outcomes

Author(s): Cheyroux P; Morin AJS; O' Connor RM; Colombat P; Vancappel A; Eltanoukhi R; Gillet N;

This study aims to contribute to an improved dynamic person-centred comprehension of the distinct trajectories of alcohol-related problems observed among first-year nursing students. Data was collected from 2963 first-year nursing students on four occasions over the course of their first semester ...

Article GUID: 41797206


Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial

Author(s): Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC;

Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing P ...

Article GUID: 41795685


Efficient self-supervised Barlow Twins from limited tissue slide cohorts for colonic pathology diagnostics

Author(s): Notton C; Sharma V; Quoc-Huy Trinh V; Chen L; Xu M; Varma S; Hosseini MS;

Colorectal cancer (CRC) is one of the few cancers that have an established dysplasia-carcinoma sequence that benefits from screening. Everyone over 50 years of age in Canada is eligible for CRC screening. About 20% of those people will undergo a biopsy for a pre-neoplastic polyp and, in many cases, multiple polyps. As such, these polyp biopsies make up th ...

Article GUID: 41793844


Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome

Author(s): Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G;

Background: Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite recognition of the gut microbiome's role in metabolic health, there remains scope for defining association of unique microbes with cl ...

Article GUID: 41794383


Neural topic modeling on hyperspheres: Spherical representation learning with von Mises-Fisher mixtures

Author(s): Guo D; Luo Z; Bouguila N; Fan W;

Neural topic models (NTMs) based on variational autoencoders (VAEs) have emerged as a scalable and flexible alternative to classical probabilistic models for uncovering latent thematic structures in text corpora. However, most existing NTMs either overlook the geometric structure of word embeddings or rely on Euclidean priors that are poorly aligned with ...

Article GUID: 41791177


Season and city shape urban bioaerosol composition beyond vegetation and socioeconomic gradients

Author(s): Poirier S; Rondeau-Leclaire J; Faticov M; Roy A; Lajeunesse G; Lucier JF; Tardif S; Kembel SW; Ziter C; Laprise C; Paquette A; Girard C; Laforest-Lapointe I;

Urban vegetation varies with socio-economic gradients, as lower-income neighborhoods often host sparser and less diverse green spaces. This disparity may affect respiratory health by influencing exposure to bioaerosols. Understanding the characteristics of this aerobiome could help anticipate ris ...

Article GUID: 41785576


Blending Poly(dimethylsiloxane) with Poly(lactic acid) Using Polyhydroxyurethane Additives

Author(s): Younes GR; Heli B; Ajji A;

This work blends polydimethylsiloxane (PDMS) with poly-(lactic acid) (PLA) using polyhydroxyurethane (PHU) structures. The PHU is synthesized from mannitol biscarbonate and a short-chain PDMS-based diamine. The main objectives are, first, to explore the application of the PDMS-based PHU as an additive for PLA and, second, to enhance the flexibility and hy ...

Article GUID: 41783236


Achilles tendon ultrasound-derived properties of the dominant and non-dominant jumping leg of university basketball athletes: relation with performance, range of motion, and injury

Author(s): Soontjens O; Busner J; Fortin M;

Introduction: The Achilles tendon (AT) plays a crucial role in force transmission and movement efficiency, and greater tendon stiffness may enhance elastic energy storage and improve performance in explosive movements. Shear-wave elastography (SWE) enables reliable, non-invasive assessment of tendon stiffness, yet its associations with other ultrasound (U ...

Article GUID: 41783785


Benzylisoquinoline Alkaloid Production in Yeast via Norlaudanosoline Improves Titer, Selectivity, and Yield

Author(s): Narcross L; Pyne ME; Kevvai K; Siu KH; Dueber JE; Martin VJJ;

The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises >2,500 members, including the pharmaceuticals morphine, codeine, and papaverine, as well as the antibiotics sanguinarine and chelerythrine. Agricultural cultivation can supply the demand for the BIAs that accumulate in plants, but broader access to the BIA family wou ...

Article GUID: 41779670


Phenogenomics reveals the ecology and evolution of Trichoderma fungi for sustainable agriculture

Author(s): Steindorff AS; Cai FM; Ding M; Jiang S; Atanasova L; Baker SE; Barbosa-Filho JR; Bayram Akcapinar G; Brown DW; Chaverri P; Chen P; Chenthamara K; Daum C; Drula E; Dubey M; Brandström Durling M; Flatschacher D; Ebner T; Emri T; Gao R; Geo ...

Trichoderma fungi support sustainable agriculture by suppressing plant diseases and improving crop performance. However, emerging pathogenicity of Trichoderma warrants further ecological and genetic characterization. Here we used machine learning to correlate genomic data from 37 Trichoderma stra ...

Article GUID: 41775999


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