Author(s): Jobin B; Frasnelli J; Phillips NA; Boller B;

Background: Olfactory identification is impaired early in the clinical continuum of Alzheimer's disease (AD) and is already observable in mild cognitive impairment (MCI). A recent meta-analysis showed significant associations between olfactory identification and episodic memory scores in older adults without cognitive impairment. Thus, olfactory ident ...

Article GUID: 41443638

Author(s): Grant N; Phillips NA;

Background: Age-related hearing loss (HL) is associated with poorer cognition and increased risk of developing dementia. However, few studies have explored if sex affects the association between HL and cognition. We investigated the relationship between two hearing measures and performance on cognitive screening and neuropsychological tests in males and f ...

Article GUID: 41443651

Author(s): Kouzoukas E; Navas C; Zawertailo L; Fougere C; Bacon SL; Chadi N; Evans WK; McNeill A; Melamed O; Moraes TJ; Nnorom O; Schwartz R; Shahab L; Ween M; Selby P;

Objective: To develop evidence-informed recommendations on the health effects of e-cigarettes to guide healthcare practitioners and the public to balance individual and population harm reduction. Methods: Systematic and umbrella reviews investigating the health effects of e-cigarette use were co ...

Article GUID: 41443121

Author(s): Tristin Best

Background: Olfactory dysfunction is a prevalent and early symptom of Alzheimer's disease (AD), often preceding the core memory impairment features of AD. Moreover, brain regions integral to olfactory processing are implicated in the early AD pathophysiology. Previous work has identified olfactory deficits in individuals with subjective cognitive decl ...

Article GUID: 41441548

Author(s): Mosharafian S; Jaeger JAG;

Rapid increases in urban sprawl in many cities across the planet pose a challenge that needs to be addressed urgently. This study proposes targets, limits, and warning values to urban sprawl as a quantitative reference framework for exploring potential future pathways and to provide guidance for future land management. The reference framework serves to ev ...

Article GUID: 41436679

Author(s): Hervé V; KaAli OB; Benali H; Brouillette J;

Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aßo), which begins in the brain approximately 15 years prior to the onset of clinical symptoms. Aßo-induced neuronal hyperactivity has emerged as an early functional characteristic of AD, contributing to synaptic deficits, ...

Article GUID: 41436083

Author(s): Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ;

Background: Circulating sex hormones decrease in aging, influencing cerebrovascular health, a key factor in dementia risk. Early menopause is a risk factor for dementia comparable to smoking2. Estradiol consistently supports female vasculature1 and brain health, though its effects on cerebrovascular health is understudied. Testosterone's effects in ma ...

Article GUID: 41433411

Author(s): Silva NCBS; Stein RG; Gu Y; Hsu CL; Tam RC; Salluzzi M; McCreary CR; Alkeridy WA; Lam K; MacKay AL; Kolind S; Cossette B; Griffith LE; Hogan DB; McMillan JM; Raina P; Smith EE; Liu-Ambrose T;

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19 and has infected >700 million persons worldwide. Individuals infected with SARS-CoV-2 are at risk for cognitive decline and at higher risk of dementia compared with those diagnosed with oth ...

Article GUID: 41434542

Author(s): Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ;

Background: Circulating sex hormones decrease in aging, influencing cerebrovascular health, a key factor in dementia risk. Early menopause is a risk factor for dementia comparable to smoking2. Estradiol consistently supports female vasculature1 and brain health, though its effects on cerebrovascular health is understudied. Testosterone's effects in ma ...

Article GUID: 41435069

Author(s): Silva NCBS; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy WA; Kramer AF; Liu-Ambrose T;

Background: Physical activity is associated with higher myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying these associations remain understudied. High-density lipoprotein (HDL) is involved i ...

Article GUID: 41435075

Author(s): Pieruccini-Faria F; Son S; Liu-Ambrose T; Burhan AM; Almeida QJ; Middleton LE; Li K; Fraser S; Bherer L; Montero-Odasso M;

Background: Mild Cognitive Impairment (MCI) may be associated with the presence of the apolipoprotein E4 allele (APOE4), a genetic factor linked to accelerated cognitive decline. The SYNERGIC trial demonstrated that physical exercise (PE) involving aerobic and resistance training improves global ...

Article GUID: 41435121