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Multilingualism and cognitive reserve in older adults with, or at risk for, Alzheimer s disease: Evidence from resting-state functional connectivity

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional b ...

Article GUID: 42208339


A gender-sensitized lifestyle intervention powered by sport fandom in men with overweight or obesity: a 1-year cost-effectiveness analysis of the Hockey FIT Trial

Author(s): Marsh JD; Silva NCBS; Gill DP; Riggin B; Zou G; Stranges S; Zwarenstein M; Petrella RJ;

Background/objectives: To describe the program-related costs and estimate the cost-effectiveness of Hockey Fans In Training (Hockey FIT), a gender-sensitized lifestyle intervention, over a 1-year period. Subjects/methods: We conducted a pragmatic, cluster randomized trial among men aged 35-65 years with a body mass index =27 kg/m2, in 39 community-base ...

Article GUID: 42209661


Keeping an Eye on Looking Measures: Towards More Robust Developmental Methods

Author(s): Sander-Montant A; Fibla L; Killam H; Byers-Heinlein K;

A persistent challenge in experimental developmental psychology is determining which of many possible outcome measures best captures underlying behaviors and processes. In the looking-while-listening paradigm for studying early word comprehension, researchers have developed more than 12 distinct outcome measures, but have limited empirical basis for cho ...

Article GUID: 42206598


Investigating substrate specificity in arogenate versus prephenate dehydratases

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, re ...

Article GUID: 42204708


Just noticeable difference thresholds of asynchrony and non-isochrony in a Multi-Instrumental groove-based context

Author(s): Câmara GS; Spiech C; Solli S; Bang B; Rogulina O; Laeng B; Danielsen A;

Musicians convey timing "feels" in groove-based performance by manipulating onset asynchrony between instruments and the durational ratio of metrical subdivisions (non-isochrony, or "swing"). The present study tested whether listeners perceive such fine-grained timing deviations by measuring the just-noticeable difference (JND) thres ...

Article GUID: 42201766


Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages

Author(s): Peng C; Liggio J; Moussa SG; Tang Y; Johannessen C; Zhang X; Zhang Z; Li L; Harner T; Saini A; Hung H; Wentzell J; Wheeler MJ; Dabek-Zlotorzynska E; Yassine M; Liu Q; Tang M; Friel-Bartlett Z; Abdul-Sater AA;

Antioxidants added to tires to prevent degradation have recently been recognized as emerging environmental contaminants. While their acute aquatic toxicity has raised concern, these compounds are also emitted to the atmosphere and can be associated with particulate matter (PM). On PM they can r ...

Article GUID: 42191547


Bilingual Families Align Their Languages During Naturalistic Interactions: Evidence from Two Bilingual Communities

Author(s): Fibla L; Kosie JE; Tsui RK; Potter CE; Lew-Williams C; Byers-Heinlein K;

Bilingual children learn their languages through rich interactions with caregivers within dynamic family contexts. However, little is known about how families align their two languages to support bilingual acquisition and how this varies across bilingual communities. This study examines language choice alignment across two communities: French-English fa ...

Article GUID: 42193667


Prevalence of Metabolically Healthy Obesity in Canadian Children and Adolescents at Entry to Pediatric Weight Management Clinic and One Year Later: A Secondary Analysis of CANadian Pediatric Weight Management Registry Data

Author(s): Cohen TR; Bains A; Ball GDC; Faustini C; Heidl A; Morrison KM;

Few studies have characterized metabolically healthy (MHO) and unhealthy obesity (MUO) in pediatric populations over time. The objective of this study was to determine the prevalence of MHO in children and adolescents enrolled in a weight management program and examine changes in cardiometabolic indicators over 1 year.Methods: Participants from the CANa ...

Article GUID: 42189064


Prise en charge de la multimorbidité cœur-cerveau : un guide de pratique clinique

Author(s): Edwards JD; Li Z; McFarlane P; Rabi DM; Gilbert J; Bajaj HS; MacIntosh BJ; Bittman J; Feldman RD; Dresser G; Terenzi K; Swartz R; Gabor J; Pearson GJ; Selby P; Wharton S; Warburton DER; Pakhalé S; Styra R; Baker B; Tu K; Hawkins M; Sto ...

id="fra-abstract"> Contexte: Les maladies du cœur et les maladies du cerveau partagent divers facteurs de risque et elles coexistent souvent; pourtant, les guides de pratique clinique en cardiologie et en neurologie sont le plus souvent produits en silos disciplinaires. Élaboré par un ...

Article GUID: 42185004


Is Pain Intensity Associated With Sleep-Spindle Activity in Persons With Chronic Spinal Pain and Chronic Insomnia Disorder? A Polysomnography Study

Author(s): Runge N; Walsh N; Dang-Vu TT; De Baets L; Labie C; Bilterys T; Verschueren S; Van Assche D; Nijs J; Malfliet A; Danneels L; Ickmans K; Moens M; Goubert D; Mairesse O; Paez A;

Chronic spinal pain is associated with fragmented sleep, yet the neurophysiological mechanisms linking the two remain unclear. Given their role in sensory gating and sleep stability, sleep spindles may represent a key mechanism connecting chronic spinal pain and sleep fragmentation. This study ...

Article GUID: 42186730


Practices to Reduce Stigma and Discrimination Towards Older Transitional Housing Clients

Author(s): Canham SL; Richardson LR; Aaenson-Fletcher J; Weldrick R; Walsh CA;

Homelessness remains an enduring social issue, in part, due to the stigmatization of and discrimination toward people experiencing homelessness, known as homeism. Despite extant research on the topic, little is known about how homeism, enacted through stigmatization and discrimination, may occur within transitional housing programs or among older people ...

Article GUID: 42184413


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