PERFORM Publications

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Title		Authors	PubMed ID
1	A Public Health Ethics Case for Mitigating Zoonotic Disease Risk in Food Production	Bernstein J; Dutkiewicz J;	33997264 SOCANTH
2	Zoo soundscape: Daily variation of low-to-high-frequency sounds.	Pelletier C, Weladji RB, Lazure L, Paré P	32735724 BIOLOGY
3	Enzymes of early-diverging, zoosporic fungi.	Lange L, Barrett K, Pilgaard B, Gleason F, Tsang A	31309267 CSFG
4	Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study.	Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH	28510905 PERFORM

Title:	Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study.
Authors:	Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28510905?dopt=Abstract
DOI:	10.1007/s10548-017-0568-9
Publication:	Brain topography
Keywords:	Combined EEG/MEG; Epileptic activity; Focal cortical dysplasia type IIb; Realistic finite element head model; Skull conductivity calibration; Source reconstruction; Zoomed MRI;
PMID:	28510905	Category:	Brain Topogr	Date Added:	2019-06-04
Dept Affiliation:	PERFORM 1 Institute for Biomagnetism und Biosignalanalysis, University of Münster, Malmedyweg 15, 48149, Münster, Germany. umit.aydin@uni-muenster.de. 2 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Centre, Concordia University, Montreal, Quebec, Canada. umit.aydin@uni-muenster.de. 3 Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany. 4 Institute for Biomagnetism und Biosignalanalysis, University of Münster, Malmedyweg 15, 48149, Münster, Germany. 5 Department of Clinical Radiology, University Hospital Münster, Münster, Germany. 6 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. 7 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Centre, Concordia University, Montreal, Quebec, Canada. 8 Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada. 9 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 10 Ruhr-Epileptology, Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Bochum, Germany.

Description:

Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study.

Brain Topogr. 2017 Jul;30(4):417-433

Authors: Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH

Abstract

In recent years, the use of source analysis based on electroencephalography (EEG) and magnetoencephalography (MEG) has gained considerable attention in presurgical epilepsy diagnosis. However, in many cases the source analysis alone is not used to tailor surgery unless the findings are confirmed by lesions, such as, e.g., cortical malformations in MRI. For many patients, the histology of tissue resected from MRI negative epilepsy shows small lesions, which indicates the need for more sensitive MR sequences. In this paper, we describe a technique to maximize the synergy between combined EEG/MEG (EMEG) source analysis and high resolution MRI. The procedure has three main steps: (1) construction of a detailed and calibrated finite element head model that considers the variation of individual skull conductivities and white matter anisotropy, (2) EMEG source analysis performed on averaged interictal epileptic discharges (IED), (3) high resolution (0.5 mm) zoomed MR imaging, limited to small areas centered at the EMEG source locations. The proposed new diagnosis procedure was then applied in a particularly challenging case of an epilepsy patient: EMEG analysis at the peak of the IED coincided with a right frontal focal cortical dysplasia (FCD), which had been detected at standard 1 mm resolution MRI. Of higher interest, zoomed MR imaging (applying parallel transmission, 'ZOOMit') guided by EMEG at the spike onset revealed a second, fairly subtle, FCD in the left fronto-central region. The evaluation revealed that this second FCD, which had not been detectable with standard 1 mm resolution, was the trigger of the seizures.

PMID: 28510905 [PubMed - indexed for MEDLINE]

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