PERFORM Publications

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Title		Authors	PubMed ID
1	Benzylisoquinoline Alkaloid Production in Yeast via Norlaudanosoline Improves Titer, Selectivity, and Yield	Narcross L; Pyne ME; Kevvai K; Siu KH; Dueber JE; Martin VJJ;	41779670 BIOLOGY
2	PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database	Greco BM; Zapata G; Dandage R; Papkov M; Pereira V; Lefebvre F; Bourque G; Parts L; Kuzmin E;	40580499 BIOLOGY
3	A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome	Zykaj E; Abboud C; Asadi P; Warsame S; Almousa H; Milev MP; Greco BM; López-Sánchez M; Bratkovic D; Kachroo AH; Pérez-Jurado LA; Sacher M;	39273027 BIOLOGY
4	Genome sequencing of 15 acid-tolerant yeasts	Bagley JA; Pyne ME; Exley K; Kevvai K; Wang Q; Whiteway M; Martin VJJ;	37747226 BIOLOGY
5	Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast	Sultana S; Abdullah M; Li J; Hochstrasser M; Kachroo AH;	37364278 BIOLOGY
6	Rapid, scalable, combinatorial genome engineering by marker-less enrichment and recombination of genetically engineered loci in yeast	Abdullah M; Greco BM; Laurent JM; Garge RK; Boutz DR; Vandeloo M; Marcotte EM; Kachroo AH;	37323580 BIOLOGY
7	Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	Pyne ME; Gold ND; Martin VJJ;	37004909 BIOLOGY
8	The MyLo CRISPR-Cas9 Toolkit: A Markerless Yeast Localization and Overexpression CRISPR-Cas9 Toolkit	Bean BDM; Whiteway M; Martin VJJ;	35708612 BIOLOGY
9	Humanized yeast to model human biology, disease and evolution	Kachroo AH; Vandeloo M; Greco BM; Abdullah M;	35661208 BIOLOGY
10	Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast	Garge RK; Cha HJ; Lee C; Gollihar JD; Kachroo AH; Wallingford JB; Marcotte EM;	34849907 BIOLOGY
11	Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.	Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI	32630624 BIOLOGY
12	SOD1 oxidation and formation of soluble aggregates in yeast: relevance to sporadic ALS development.	Martins D, English AM	24936435 CHEMBIOCHEM
13	Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.	Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI	25839782 MASSSPEC
14	Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.	Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI	29050207 BIOLOGY
15	Some Metabolites Act as Second Messengers in Yeast Chronological Aging.	Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI	29543708 BIOLOGY
16	Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.	Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI	29662634 BIOLOGY
17	Single-step Precision Genome Editing in Yeast Using CRISPR-Cas9.	Akhmetov A, Laurent JM, Gollihar J, Gardner EC, Garge RK, Ellington AD, Kachroo AH, Marcotte EM	29770349 BIOLOGY
18	Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.	Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI	30405886 BIOLOGY
19	Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.	Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI	30719227 BIOLOGY
20	The evolutionary rewiring of the ribosomal protein transcription pathway modifies the interaction of transcription factor heteromer Ifh1-Fhl1 (interacts with forkhead 1-forkhead-like 1) with the DNA-binding specificity element.	Mallick J, Whiteway M	23625919 BIOLOGY
21	Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast.	Pinel D, Colatriano D, Jiang H, Lee H, Martin VJ	25866561 CSFG
22	Reconstituting Plant Secondary Metabolism in Saccharomyces cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids.	Pyne ME, Narcross L, Fossati E, Bourgeois L, Burton E, Gold ND, Martin VJ	27417930 CSFG
23	Determinants of selection in yeast evolved by genome shuffling.	Biot-Pelletier D, Pinel D, Larue K, Martin VJJ	30356826 CSFG

Title:	Some Metabolites Act as Second Messengers in Yeast Chronological Aging.
Authors:	Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI
Link:	https://www.ncbi.nlm.nih.gov/pubmed/29543708?dopt=Abstract
DOI:	10.3390/ijms19030860
Publication:	International journal of molecular sciences
Keywords:	cell signaling; chronological aging; interorganellar communications; mechanisms of longevity regulation; metabolism; mitochondria; proteostasis; regulated cell death; second messengers; yeast;
PMID:	29543708	Category:	Int J Mol Sci	Date Added:	2019-06-07
Dept Affiliation:	BIOLOGY 1 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. karamat.mohammad@concordia.ca. 2 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. pameladakik@gmail.com. 3 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. writetoyounes@gmail.com. 4 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. melissa.mcauley@concordia.ca. 5 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. mitrofanova_darya@hotmail.com. 6 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. vladimir.titorenko@concordia.ca.

Description:

Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Int J Mol Sci. 2018 Mar 15;19(3):

Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Abstract

The concentrations of some key metabolic intermediates play essential roles in regulating the longevity of the chronologically aging yeast Saccharomyces cerevisiae. These key metabolites are detected by certain ligand-specific protein sensors that respond to concentration changes of the key metabolites by altering the efficiencies of longevity-defining cellular processes. The concentrations of the key metabolites that affect yeast chronological aging are controlled spatially and temporally. Here, we analyze mechanisms through which the spatiotemporal dynamics of changes in the concentrations of the key metabolites influence yeast chronological lifespan. Our analysis indicates that a distinct set of metabolites can act as second messengers that define the pace of yeast chronological aging. Molecules that can operate both as intermediates of yeast metabolism and as second messengers of yeast chronological aging include reduced nicotinamide adenine dinucleotide phosphate (NADPH), glycerol, trehalose, hydrogen peroxide, amino acids, sphingolipids, spermidine, hydrogen sulfide, acetic acid, ethanol, free fatty acids, and diacylglycerol. We discuss several properties that these second messengers of yeast chronological aging have in common with second messengers of signal transduction. We outline how these second messengers of yeast chronological aging elicit changes in cell functionality and viability in response to changes in the nutrient, energy, stress, and proliferation status of the cell.

PMID: 29543708 [PubMed - indexed for MEDLINE]

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