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PubMed Publications| Keyword search (4,164 papers available) |  |
"white matter" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Variations in perfusion detectable in advance of microstructure in white matter aging | Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ; | 40694306 PHYSICS |
| 2 | Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions | Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM; | 40585093 PSYCHOLOGY |
| 3 | Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease | Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 40086421 PSYCHOLOGY |
| 4 | Physical activity may protect myelin via modulation of high-density lipoprotein | Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T; | 39989020 HKAP |
| 5 | Music reward sensitivity is associated with greater information transfer capacity within dorsal and motor white matter networks in musicians | Matthews TE; Lumaca M; Witek MAG; Penhune VB; Vuust P; | 39052097 PSYCHOLOGY |
| 6 | MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics | Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ; | 38463982 SOH |
| 7 | Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease | Xiao Y; Peters TM; Khan AR; | 34106502 PERFORM |
| 8 | White matter microstructural changes in short-term learning of a continuous visuomotor sequence | Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; | 33885965 PERFORM |
| 9 | The descending motor tracts are different in dancers and musicians. | Giacosa C, Karpati FJ, Foster NEV, Hyde KL, Penhune VB | 31620887 PSYCHOLOGY |
| 10 | Inferior Longitudinal Fasciculus' Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study. | Shin J, Rowley J, Chowdhury R, Jolicoeur P, Klein D, Grova C, Rosa-Neto P, Kobayashi E | 31507359 PERFORM |
| 11 | Arterial stiffness and brain integrity: A review of MRI findings. | Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ | 31063866 PERFORM |
| Title: | Physical activity may protect myelin via modulation of high-density lipoprotein | ||||
| Authors: | Boa Sorte Silva NC, Balbim GM, Stein RG, Gu Y, Tam RC, Dao E, Alkeridy W, Lam K, Kramer AF, Liu-Ambrose T | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/39989020/ | ||||
| DOI: | 10.1002/alz.14599 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | aging; cerebrovascular health; exercise; fitness; lipids; neurodegeneration; white matter; | ||||
| PMID: | 39989020 | Category: | Date Added: | 2025-02-24 | |
| Dept Affiliation: |
HKAP
1 Department of Health, Kinesiology, and Applied Physiology, Faculty of Arts and Science, Concordia University, Montréal, Québec, Canada. 2 Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 3 School of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 4 Department of Medicine, King Saud University, College of Medicine, Riyadh, Saudi Arabia. 5 Department of Medicine, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 6 Department of Psychology, Northeastern University, Boston, Massachusetts, USA. |
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Description: |
Introduction: Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied. Methods: We assessed cross-sectionally whether serum high-density lipoprotein (HDL), low-density lipoprotein, and triglycerides moderated the association between physical activity and in vivo myelin in older individuals with CSVD and mild cognitive impairment. Results: We included 81 highly educated, community-dwelling older individuals (mean age 74.57 years), 64% of whom were female. Regression models revealed that HDL levels significantly moderated the relationship between physical activity and myelin in the sagittal stratum, wherein higher physical activity levels were linked to greater myelin levels for those with average or high HDL (standardized B [95% CI] = 0.289 [0.087 to 0.491], p = 0.006). Discussion: Physical activity may promote myelin health partly through HDL. Data from longitudinal studies are needed to confirm our findings. Highlights: Myelin loss is common in individuals with cerebral small vessel disease (CSVD). Physical activity was positively associated with myelin in older adults with CSVD. High-density lipoproteins (HDL) levels were also positively related to myelin. Physical activity effects on myelin were moderated by HDL levels. |
