PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss	Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;	40831565 SOH
2	The hockey fans in training intervention for men with overweight or obesity: a pragmatic cluster randomised trial	Petrella RJ; Gill DP; Boa Sorte Silva NC; Riggin B; Blunt WM; Kfrerer M; Majoni M; Marsh J; Irwin JD; Stranges S; Zwarenstein M; Zou G;	39568632 HKAP
3	Electroacupuncture Reduces Heart Rate and Perceived Exertion During a Bike Test: A Preliminary Analysis	Gaudet E; Castonguay T; Fortin M; Dover G;	39457342 HKAP
4	Improvements in cardiorespiratory fitness, muscle strength and body composition to modest weight loss are similar in those with adult- versus childhood-onset obesity	Lucas Guimarães Almeida	37794721 SOH
5	Acceptability of a structured diet and exercise weight loss intervention in breast cancer survivors living with an overweight condition or obesity: A qualitative analysis.	Beckenstein H, Slim M, Kim H, Plourde H, Kilgour R, Cohen TR	33491338 PERFORM
6	Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.	Murphy J, Moullec G, Santosa S	28081776 PERFORM
7	Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight	Kakinami L; Houle-Johnson SA; Demissie Z; Santosa S; Fulton JE;	30456053 PERFORM

Title:	Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.
Authors:	Murphy J, Moullec G, Santosa S
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28081776?dopt=Abstract
DOI:	10.1016/j.metabol.2016.09.009
Publication:	Metabolism: clinical and experimental
Keywords:	Adipocyte size; Adipose tissue dysfunction; Obesity; Weight loss;
PMID:	28081776	Category:	Metabolism	Date Added:	2019-04-15
Dept Affiliation:	PERFORM 1 Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5. 2 Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5; École de Santé Publique - Département de Médecine Sociale et Preventive, Université de Montréal, 7101 du Parc Ave., Montreal, Quebec, Canada, H3N 1X9. 3 Department of Exercise Science, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, Quebec, Canada, H4B 1R6; Centre de Recherche - Axe Maladies Chroniques, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd. W., Montreal, Quebec, Canada, H4J 1C5. Electronic address: s.santosa@concordia.ca.

Description:

Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression.

Metabolism. 2017 Feb;67:31-40

Authors: Murphy J, Moullec G, Santosa S

Abstract

AIMS: Enlarged adipocytes are a prime feature of adipose tissue dysfunction, and may be an appropriate target to decrease disease risk in obesity. We aimed to assess the change in adipocyte size in response to lifestyle and surgical weight loss interventions for overweight or obesity; and to explore whether certain participant and intervention characteristics influence this response.

METHODS: We systematically searched MEDLINE, EMBASE, CINAHL and Cochrane electronic databases to identify weight loss studies that quantified adipocyte size before and after the intervention. Using meta-regression analysis, we assessed the independent effects of weight loss, age, sex, adipocyte region, and intervention type (surgical vs. lifestyle) on adipocyte size reduction. We repeated the model as a sensitivity analysis including only the lifestyle interventions.

RESULTS: Thirty-five studies met our eligibility criteria. In our main model, every 1.0% weight loss was associated with a 0.64% reduction in adipocyte size (p=0.003); and adipocytes from the upper body decreased 5% more in size than those in the lower body (p=0.009). These relationships were no longer significant when focusing only on lifestyle interventions. Moreover, age, sex and intervention type did not independently affect adipocyte size reduction in either model.

CONCLUSIONS: Weight loss in obese individuals is consistently associated with a decrease in adipocyte size that is more pronounced in upper-body adipocytes. It remains to be clarified how biological differences and intervention characteristics influence this relationship, and whether it corresponds with reductions in other aspects of adipose tissue dysfunction and disease risk.

PMID: 28081776 [PubMed - indexed for MEDLINE]

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