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Title Authors PubMed ID
1 An examination of the quinic acid utilization genes in Aspergillus niger reveals the involvement of two pH-dependent permeases Sgro M; Reid ID; Arentshorst M; Ram AFJ; Tsang A; 40853219
GENOMICS
2 Exploiting protein language models for the precise classification of ion channels and ion transporters Ghazikhani H; Butler G; 38656743
CSFG
3 Zinc Homeostasis in Diabetes Mellitus and Vascular Complications MacKenzie S; Bergdahl A; 35052818
HKAP
4 TooT-T: discrimination of transport proteins from non-transport proteins. Alballa M, Butler G 32321420
CSFG
5 The effects of external Mn2+ concentration on hyphal morphology and citric acid production are mediated primarily by the NRAMP-family transporter DmtA in Aspergillus niger. Fejes B, Ouedraogo JP, Fekete E, Sándor E, Flipphi M, Soós Á, Molnár ÁP, Kovács B, Kubicek CP, Tsang A, Karaffa L 32000778
CSFG
6 Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity. Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L 28774705
PSYCHOLOGY

 

Title:Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.
Authors:Ismaylova E,  Di Sante J,  Szyf M,  Nemoda Z,  Yu WJ,  Pomares FB,  Turecki G,  Gobbi G,  Vitaro F,  Tremblay RE,  Booij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/28774705?dopt=Abstract
DOI:10.1016/j.euroneuro.2017.07.005
Publication:European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Keywords:DNA methylation;  Frontal cortex;  Functional magnetic resonance imaging;  Resilience;  Serotonin transporter; 
PMID:28774705 Category:Eur Neuropsychopharmacol Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada.
2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
3 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
4 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada.
5 Douglas Mental Health University Institute, Verdun, Canada; Department of Psychiatry, McGill University, Montreal, Canada.
6 Department of Psychiatry, McGill University, Montreal, Canada.
7 CHU Sainte-Justine Research Centre, Montreal, Canada; School of Psychoeducation, University of Montreal, Montreal, Canada.
8 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland.
9 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Eur Neuropsychopharmacol. 2017 10;27(10):1032-1041

Authors: Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Abstract

Early adversity can influence gene expression via epigenetic mechanisms, including DNA methylation. Peripheral tissues are essential in psychiatric epigenetics, as methylation generally cannot be assessed in the living human brain. Several magnetic resonance imaging (MRI) studies show associations of peripheral serotonin transporter gene (SLC6A4) methylation with function and/or structure of frontal-limbic circuits and brain's resting-state. Commonly used samples are derived from blood, saliva or buccal cells. However, little is known regarding which peripheral tissue is most strongly associated with human brain processes. The aim of the current study was to compare the extent of the association between peripheral SLC6A4 promoter methylation and frontal-limbic function, structure and resting-state in healthy individuals across peripheral tissues. Forty healthy prospectively-followed adults underwent anatomical, resting-state and functional MRI. Saliva-, blood- and buccal-derived DNA methylation was assessed by pyrosequencing. Blood-derived SLC6A4 methylation was positively associated with superior frontal gray matter (GM) volume and with right lateral parietal area (RLP)-frontal pole regional resting-state functional connectivity (rsFC). Saliva-derived SLC6A4 methylation was positively associated with superior frontal GM volume. Buccal-derived SLC6A4 methylation was positively associated with superior and inferior frontal and anterior cingulate cortical (ACC) GM volumes, and with RLP-ACC, frontal pole and medial prefrontal regional rsFC. Current results confirmed the relevance of peripheral methylation for frontal-limbic processes in humans. Buccal cells may be the most sensitive cell type when studying SLC6A4 promoter methylation and its associated risk for neural vulnerability and resilience for psychopathologies in which serotonin is implicated. These data should be further validated in clinical populations.

PMID: 28774705 [PubMed - indexed for MEDLINE]




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