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PubMed Publications| Keyword search (4,163 papers available) |  |
"systems biology" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Exploiting fluctuations in gene expression to detect causal interactions between genes | Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A; | 41401079 BIOLOGY |
| 2 | Protocol for evaluating neuronal activity and neurotransmitter release following amyloid-beta oligomer injections into the rat hippocampus | Hervé V; Bonenfant L; Amyot M; Balafrej R; Ali OBK; Benali H; Brouillette J; | 40131934 ENCS |
| 3 | Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds | Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT; | 37888959 BIOLOGY |
| 4 | Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database | Rurak GM; Simard S; Freitas-Andrade M; Lacoste B; Charih F; Van Geel A; Stead J; Woodside B; Green JR; Coppola G; Salmaso N; | 35108542 ENCS |
| 5 | Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast | Garge RK; Cha HJ; Lee C; Gollihar JD; Kachroo AH; Wallingford JB; Marcotte EM; | 34849907 BIOLOGY |
| Title: | Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database | ||||
| Authors: | Rurak GM, Simard S, Freitas-Andrade M, Lacoste B, Charih F, Van Geel A, Stead J, Woodside B, Green JR, Coppola G, Salmaso N | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35108542/ | ||||
| DOI: | 10.1016/j.celrep.2022.110310 | ||||
| Publication: | Cell reports | ||||
| Keywords: | astrocyte; cortex; development; females; gene regulation; glia; sex; systems biology; translatome; | ||||
| PMID: | 35108542 | Category: | Date Added: | 2022-02-03 | |
| Dept Affiliation: |
ENCS
1 Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada. 2 Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada. 3 Department of Systems and Computer Engineering, Carleton University, Ottawa, ON, Canada. 4 Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada; Concordia University, Montreal, QC, Canada. 5 Department of Pathology, Yale University, 333 Cedar St., New Haven, CT 06511, USA. Electronic address: gianfilippo.coppola@yale.edu. 6 Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada; Department of Pathology, Yale University, 333 Cedar St., New Haven, CT |
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Description: |
Astroglial cells are key players in the development and maintenance of neurons and neuronal networks. Astroglia express steroid hormone receptors and show rapid responses to hormonal manipulations. However, despite important sex differences in the cortex and hippocampus, few studies have examined sex differences in astroglial cells in telencephalic development. To characterize the cortical astroglial translatome in male and female mice across postnatal development, we use translating ribosome affinity purification together with RNA sequencing and immunohistochemistry to phenotype astroglia at six developmental time points. Overall, we find two distinct astroglial phenotypes between early (P1-P7) and late development (P14-adult), independent of sex. We also find sex differences in gene expression patterns across development that peak at P7 and appear to result from males reaching a mature astroglial phenotype earlier than females. These developmental sex differences could have an impact on the construction of neuronal networks and windows of vulnerability to perturbations and disease. |
