Keyword search (4,164 papers available)

"striatum" Keyword-tagged Publications:

Title Authors PubMed ID
1 Combined effects of the contraceptive hormones, ethinyl estradiol and levonorgestrel, on the use of place and response memory in gonadally-intact female rats Lacasse JM; Boulos V; Fisher C; Hamilton S; Heron M; Mac Cionnaith CE; Peronace V; Tito N; Brake WG; 36403510
PSYCHOLOGY
2 Sexually dimorphic role of circadian clock genes in alcohol drinking behavior Nuria de Zavalia 36184679
PSYCHOLOGY
3 The role of progesterone in memory bias during spatial navigation in females Eamonn L Gomez-Perales 36165431
PSYCHOLOGY
4 Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons Almey A; Milner TA; Brake WG; 35397175
CSBN
5 Progesterone rapidly alters the use of place and response memory during spatial navigation in female rats Lacasse JM; Patel S; Bailey A; Peronace V; Brake WG; 35158200
PSYCHOLOGY
6 The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands Howland JG; Ito R; Lapish CC; Villaruel FR; 35131398
PSYCHOLOGY
7 Analyses of microstructural variation in the human striatum using non-negative matrix factorization Robert C; Patel R; Blostein N; Steele CC; Mallar Chakravarty M; 34848302
PSYCHOLOGY
8 Chronic Neuroleptic-Induced Parkinsonism Examined with Positron Emission Tomography. Galoppin M, Berroir P, Soucy JP, Suzuki Y, Lavigne GJ, Gagnon JF, Montplaisir JY, Stip E, Blanchet PJ 32353194
PERFORM

 

Title:Analyses of microstructural variation in the human striatum using non-negative matrix factorization
Authors:Robert CPatel RBlostein NSteele CCMallar Chakravarty M
Link:pubmed.ncbi.nlm.nih.gov/34848302/
DOI:10.1016/j.neuroimage.2021.118744
Publication:NeuroImage
Keywords:Franctional anisotropyMean diffusivityMicrostructureMultimodalNon-negative matrix factorizationStriatumT1w/T2w
PMID:34848302 Category: Date Added:2021-12-01
Dept Affiliation: PSYCHOLOGY
1 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada. Electronic address: corinne.robert@mail.mcgill.ca.
2 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada.
3 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
4 Department of Psychology, Concordia University, Montreal, QC, Canada; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
5 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada; Dep

Description:

The striatum is a major subcortical connection hub that has been heavily implicated in a wide array of motor and cognitive functions. Here, we developed a normative multimodal, data-driven microstructural parcellation of the striatum using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, fractional anisotropy, and the ratio between T1- and T2-weighted structural) from the Human Connectome Project Young Adult dataset (n=329 unrelated participants, age range: 22-35, F/M: 185/144). We further explored the biological and functional relationships of this parcellation by relating our findings to motor and cognitive performance in tasks known to involve the striatum as well as demographics. We identified 5 spatially distinct striatal components, for each hemisphere. We also show the gain in component stability when using multimodal versus unimodal metrics. Our findings suggest distinct microstructural patterns in the human striatum that are largely symmetric and that relate mostly to age and sex. Our work also highlights the putative functional relevance of these striatal components to different designations based on a Neurosynth meta-analysis.




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