Keyword search (4,163 papers available)

"s Disease" Keyword-tagged Publications:

Title Authors PubMed ID
1 Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T; 41929984
HKAP
2 Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H; 41358624
PSYCHOLOGY
3 The predictive role of olfactory identification on episodic memory and mild cognitive impairment: Results from the CIMA-Q cohort Jobin B; Phillips NA; Frasnelli J; Boller B; 40944318
PSYCHOLOGY
4 The longitudinal effects of global and regional brain measurements on cognitive abilities Hosseininasabnajar F; Kakinami L; 40739300
SOH
5 Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM; 40585093
PSYCHOLOGY
6 Potential value streams of an integrated Canadian serosurveillance network Campbell JR; Russell WA; Wagner CE; Manuel DG; Anipindi V; Baral P; Evans TG; Hankins CA; Sander B; 40588636
CONCORDIA
7 Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer s disease Sanami S; Intzandt B; Huck J; Villeneuve S; Iturria-Medina Y; Gauthier CJ; Prevent-Ad Research Group None; 40347524
CONCORDIA
8 Connected speech profiles in mild cognitive impairment reflect global cognition Pellerin S; Houzé B; Bedetti C; Phillips N; Brambati SM; 40232260
PSYCHOLOGY
9 Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research Smith EE; Phillips NA; Feldman HH; Borrie M; Ganesh A; Henri-Bhargava A; Desmarais P; Frank A; Badhwar A; Barlow L; Bartha R; Best S; Bethell J; Bhangu J; Black SE; Bocti C; Bronskill SE; Burhan AM; Calon F; Camicioli R; Campbell B; Collins DL; Dadar M; DeMarco ML; Ducharme S; Duchesne S; Einstein G; Fisk JD; Gawryluk JR; Grossman L; Ismail Z; Itzhak I; Joshi M; Harrison A; Kroger E; Kumar S; Laforce R; Lanctot KL; Lau M; Lee L; Masellis M; Massoud F; Mitchell SB; Montero-Odasso M; Myers Barnett K; Nygaard HB; Pasternak SH; Peters J; Rajah MN; Robillard JM; Rockwood K; Rosa-Neto P; Seitz DP; Soucy JP; Trenaman SC; Wellington CL; Zadem A; Chertkow H; 39893139
CONCORDIA
10 Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP; 39878233
CONCORDIA
11 Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA) Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello C; Cynader M; Dang-Vu T; Das S; Dixon RA; Ducharme S; Einstein G; Evans AC; Fahnestock M; Feldman H; Ferland G; Finger E; Fisk JD; Fogarty J; Fon E; Gan-Or Z; Gauthier S; Greenwood C; Henri-Bellemare C; Herrmann N; Hogan DB; Hsiung R; Itzhak I; Jacklin K; Lanctôt K; Lim A; MacKenzie I; Masellis M; Maxwell C; McAiney C; McGilton K; McLaurin J; Mihailidis A; Mohades Z; Montero-Odasso M; Morgan D; Naglie G; Nygaard H; O' Connell M; Petersen R; Pilon R; Rajah MN; Rapoport M; Roach P; Robillard JM; Rogaeva E; Rosa-Neto P; Rylett J; Sadavoy J; St George-Hyslop P; Seitz D; Smith E; Stefanovic B; Vedel I; Walker JD; Wellington C; Whitehead V; Wittich W; 39636028
HKAP
12 Impact of Stimulation Frequency on Verbal Fluency Following Bilateral Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease Busteed L; García-Sánchez C; Pascual-Sedano B; Grunden N; Gironell A; Kulisevsky J; Pagonabarraga J; 39127889
PSYCHOLOGY
13 Cognitive Speed in Neurodegenerative Disease: Comparing Mean Rate and Inconsistency Within and Across the Alzheimer's and Lewy Body Spectra in the COMPASS-ND Study Caballero HS; McFall GP; Gee M; MacDonald S; Phillips NA; Fogarty J; Montero-Odasso M; Camicioli R; Dixon RA; 38875040
PSYCHOLOGY
14 Co-Development of Three Dietary Indices to Facilitate Dietary Intake Assessment of Pediatric Crohn's Disease Patients Harvey A.; Mannette J.; Sigall-Boneh R.; Macintyre B.; Parrott M.; Cahill L.; Connors J.; Otley A.; Haskett J.; van Limbergen J.; Grant S.; 38634640
PERFORM
15 Impaired performance of rapid grip in people with Parkinson's disease and motor segmentation Rebecca J Daniels 38507858
PSYCHOLOGY
16 The effectiveness of exercise interventions targeting sleep in older adults with cognitive impairment or Alzheimer's disease and related dementias (AD/ADRD): A systematic review and meta-analysis Arsenio Páez, Emmanuel Frimpong, Melodee Mograss, Thien Thanh Dang-Vu 38462491
HKAP
17 Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach Sasikumar DSN; Thiruselvam P; Sundararajan V; Ravindran R; Gunasekaran S; Madathil D; Kaliamurthi S; Peslherbe GH; Selvaraj G; Sudhakaran SL; 38460310
CHEMBIOCHEM
18 Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease Zhou J; Wearn A; Huck J; Hughes C; Baracchini G; Tremblay-Mercier J; Poirier J; Villeneuve S; Tardif CL; Chakravarty MM; Daugherty AM; Gauthier CJ; Turner GR; Spreng RN; 38388425
PSYCHOLOGY
19 Bayesian workflow for the investigation of hierarchical classification models from tau-PET and structural MRI data across the Alzheimer's disease spectrum Belasso CJ; Cai Z; Bezgin G; Pascoal T; Stevenson J; Rahmouni N; Tissot C; Lussier F; Rosa-Neto P; Soucy JP; Rivaz H; Benali H; 37920382
PERFORM
20 Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT; 37888959
BIOLOGY
21 Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms Pando-Naude V; Matthews TE; Højlund A; Jakobsen S; Østergaard K; Johnsen E; Garza-Villarreal EA; Witek MAG; Penhune V; Vuust P; 37724707
PSYCHOLOGY
22 Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments Vandersteen C; Plonka A; Manera V; Sawchuk K; Lafontaine C; Galery K; Rouaud O; Bengaied N; Launay C; Guérin O; Robert P; Allali G; Beauchet O; Gros A; 37416323
CONCORDIA
23 A dataset of multi-contrast unbiased average MRI templates of a Parkinson's disease population Madge V; Fonov VS; Xiao Y; Zou L; Jackson C; Postuma RB; Dagher A; Fon EA; Collins DL; 37213552
IMAGING
24 Olfactory function reflects episodic memory performance and atrophy in the medial temporal lobe in individuals at risk for Alzheimer's disease Papadatos Z; Phillips NA; 37146503
PSYCHOLOGY
25 New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice Golizeh M; Nam J; Chatelain E; Jackson Y; Ohlund LB; Rasoolizadeh A; Camargo FV; Mahrouche L; Furtos A; Sleno L; Ndao M; 36590505
CHEMBIOCHEM
26 Inhibiting amyloid beta (1-42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex Olajide OJ; La Rue C; Bergdahl A; Chapman CA; 36275011
HKAP
27 Measures of motor segmentation from rapid isometric force pulses are reliable and differentiate Parkinson's disease from age-related slowing Howard SL; Grenet D; Bellumori M; Knight CA; 35768733
PSYCHOLOGY
28 Pattern and Visual Prognostic Factors of Behcet's Uveitis in Northwest Iran Alizadeh Ghavidel L; Bagheri M; Mousavi F; Rezaei L; Hazeri S; Hashemi HS; 35765637
BIOLOGY
29 Impact of biological sex and gender-related factors on public engagement in protective health behaviours during the COVID-19 pandemic: cross-sectional analyses from a global survey Dev R; Raparelli V; Bacon SL; Lavoie KL; Pilote L; Norris CM; 35688591
HKAP
30 Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy Brodeur C; Belley É; Deschênes LM; Enriquez-Rosas A; Hubert M; Guimond A; Bilodeau J; Soucy JP; Macoir J; 35629330
IMAGING
31 Voice characteristics from isolated rapid eye movement sleep behavior disorder to early Parkinson's disease Laetitia Jeancolas 35063866
PERFORM
32 Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab Chertkow H; Rockwood K; Hogan DB; Phillips N; Montero-Odasso M; Amanullah S; Black S; Bocti C; Borrie M; Feldman H; Freedman M; Hsiung R; Kirk A; Masellis M; Nygaard H; Rajji T; Verret L; 34912492
PSYCHOLOGY
33 Comment on the article "Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome 486 (2020) 110102" Arsalan Rahimabadi 34843739
PERFORM
34 The Social Lives of Infectious Diseases: Why Culture Matters to COVID-19 Bayeh R; Yampolsky MA; Ryder AG; 34630195
PSYCHOLOGY
35 Visual Performance and Cortical Atrophy in Vision-Related Brain Regions Differ Between Older Adults with (or at Risk for) Alzheimer's Disease Sana Rehan 34397410
CRDH
36 Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex Olajide OJ; Chapman CA; 34144329
PSYCHOLOGY
37 Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease Xiao Y; Peters TM; Khan AR; 34106502
PERFORM
38 X-Vectors: New Quantitative Biomarkers for Early Parkinson's Disease Detection From Speech Jeancolas L; Petrovska-Delacrétaz D; Mangone G; Benkelfat BE; Corvol JC; Vidailhet M; Lehéricy S; Benali H; 33679361
PERFORM
39 Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease. Olajide OJ, Suvanto ME, Chapman CA 33495355
PSYCHOLOGY
40 Category-specific verb-semantic deficits in Alzheimer's disease: Evidence from static and dynamic action naming. de Almeida RG, Mobayyen F, Antal C, Kehayia E, Nair VP, Schwartz G 33455543
PSYCHOLOGY
41 Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity. Olajide OJ, Gbadamosi IT, Yawson EO, Arogundade T, Lewu FS, Ogunrinola KY, Adigun OO, Bamisi O, Lambe E, Arietarhire LO, Oluyomi OO, Idowu OK, Kareem R, Asogwa NT, Adeniyi PA 33420680
PSYCHOLOGY
42 PM2.5 and hospital admissions among Medicare enrollees with chronic debilitating brain disorders. Yitshak-Sade M, Nethery R, Schwartz JD, Mealli F, Dominici F, Di Q, Abu Awad Y, Ifergane G, Zanobetti A 33065503
PSYCHOLOGY
43 A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer's Disease Badji A; de la Colina AN; Boshkovski T; Sabra D; Karakuzu A; Robitaille-Grou MC; Gros C; Joubert S; Bherer L; Lamarre-Cliche M; Stikov N; Gauthier CJ; Cohen-Adad J; Girouard H; 32741837
PERFORM
44 Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment Pascoal TA, Therriault J, Mathotaarachchi S, Kang MS, Shin M, Benedet AL, Chamoun M, Tissot C, Lussier F, Mohaddes S, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P, 32582834
PERFORM
45 Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment Caillaud M; Hudon C; Boller B; Brambati S; Duchesne S; Lorrain D; Gagnon JF; Maltezos S; Mellah S; Phillips N; Belleville S; 31758692
CRDH
46 Computer-Aided Diagnosis System of Alzheimer's Disease Based on Multimodal Fusion: Tissue Quantification Based on the Hybrid Fuzzy-Genetic-Possibilistic Model and Discriminative Classification Based on the SVDD Model. Lazli L, Boukadoum M, Ait Mohamed O 31652635
ENCS
47 Structural brain differences between monolingual and multilingual patients with mild cognitive impairment and Alzheimer disease: Evidence for cognitive reserve Hilary D Duncan 29287966
PSYCHOLOGY
48 Flavanone glycosides inhibit β-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Aβ aggregation in the amyloidogenic pathway. Ali MY, Jannat S, Edraki N, Das S, Chang WK, Kim HC, Park SK, Chang MS 31194956
BIOLOGY
49 Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment. Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J 28522082
PERFORM
50 The movement time analyser task investigated with functional near infrared spectroscopy: an ecologic approach for measuring hemodynamic response in the motor system. Vasta R, Cerasa A, Gramigna V, Augimeri A, Olivadese G, Pellegrino G, Martino I, Machado A, Cai Z, Caracciolo M, Grova C, Quattrone A 27055849
PERFORM
51 What Is the Link Between Hallucinations, Dreams, and Hypnagogic-Hypnopompic Experiences? Waters F, Blom JD, Dang-Vu TT, Cheyne AJ, Alderson-Day B, Woodruff P, Collerton D 27358492
PERFORM
52 A dataset of multi-contrast population-averaged brain MRI atlases of a Parkinson׳s disease cohort. Xiao Y, Fonov V, Chakravarty MM, Beriault S, Al Subaie F, Sadikot A, Pike GB, Bertrand G, Collins DL 28491942
PERFORM
53 Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative 29396637
PERFORM
54 The effects of exercise on cognition and gait in Parkinson's disease: A scoping review. Intzandt B, Beck EN, Silveira CRA 30291852
PERFORM

 

Title:Flavanone glycosides inhibit β-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Aβ aggregation in the amyloidogenic pathway.
Authors:Ali MYJannat SEdraki NDas SChang WKKim HCPark SKChang MS
Link:https://www.ncbi.nlm.nih.gov/pubmed/31194956?dopt=Abstract
DOI:10.1016/j.cbi.2019.06.020
Publication:Chemico-biological interactions
Keywords:Alzheimer's diseaseBACE1DidyminFlavonoidsMolecular dockingβ-amyloid
PMID:31194956 Category:Chem Biol Interact Date Added:2019-06-14
Dept Affiliation: BIOLOGY
1 Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea; Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141, Sherbrooke St. W, Montreal, Quebec, Canada; Department of Biology, Faculty of Arts and Science, Concordia University, 7141, Sherbrooke St. W, Montreal, Quebec, Canada; Centre for Structural and Functional Genomic, Dept. of Biology, Faculty of Arts and Science, Concordia University, 7141, Sherbrooke St. W, Montreal, QC, Canada.
2 Department of Biochemistry and Molecular Biology, University of Calgary, T2N 1N4, Alberta, Canada.
3 Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4 Department of Microbiology, University of Calcutta, 35 Ballygunge, Kolkata, 700 019, India.
5 Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
6 Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address: mschang@khu.ac.kr.

Description:

Flavanone glycosides inhibit ß-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Aß aggregation in the amyloidogenic pathway.

Chem Biol Interact. 2019 Jun 10;:

Authors: Ali MY, Jannat S, Edraki N, Das S, Chang WK, Kim HC, Park SK, Chang MS

Abstract

Alzheimer's disease (AD) is a slow but progressive neurodegenerative disease. One of the pathological hallmarks of AD is the progressive accumulation of ß-amyloid (Aß) in the form of senile plaques, and Aß insult to neuronal cells has been identified as one of the major causes of AD onset. In the present study, we investigated the anti-AD potential of four flavonoids, naringenin, didymin, prunin, and poncirin, by evaluating their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and ß-site amyloid precursor protein cleaving enzyme 1 (BACE1). All four flavonoids displayed promising inhibitory activity against AChE, BChE, and BACE1. Structure-activity relationships suggested that glycosylation of naringenin at sugar moieties, and at different positions of the glycosidic linkage, might be closely associated with anti-AD potential. Kinetic and docking studies showed the lowest binding energy and highest affinity for the mixed, competitive, and non-competitive type inhibitors didymin, prunin, and poncirin. Hydrophobic interactions and the number of hydrogen bonds determined the strength of the protein-inhibitor interaction. We also examined the neuroprotective mechanisms by which flavonoids act against Aß25-35-induced toxicity in PC12?cells. Exposure of PC12?cells to 10?µM?Aß25-35 for 24?h resulted in a significant decrease in cell viability. In addition, pretreatment of PC12?cells with different concentrations of flavonoids for 1?h significantly reversed the effects of Aß. Furthermore, treatment with the most active flavonoid, didymin, significantly reduced BACE1, APPsß, and C99 expression levels in a dose-dependent manner, without affecting amyloid precursor protein (APP) levels in the amyloidogenic pathway. Together, our results indicate that flavonoids, and in particular didymin, exhibit inhibitory activity in vitro, and may be useful in the development of therapeutic modalities for the treatment of AD.

PMID: 31194956 [PubMed - as supplied by publisher]





BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University