Keyword search (4,163 papers available)

"research" Keyword-tagged Publications:

Title Authors PubMed ID
1 Updated Status of Physical Activity Research for People With Traumatic Brain Injury Quilico EL; Driver SJ; 41606762
CONCORDIA
2 Prioritising methodological research questions for scoping reviews, mapping reviews and evidence and gap maps for health research: a protocol for PROSPECT Delphi study Pollock D; Hasanoff S; McBride G; Kanukula R; Tricco AC; Khalil H; Campbell F; Jia RM; Alexander L; Peters M; Vieira AM; Aromataris E; Nunn J; Saran A; Evans C; Godfrey C; Pieper D; de Moraes ÉB; Biesty L; Colquhoun H; Devane D; Toomey E; Clyne B; Davies E; Munn Z; 40759523
SOH
3 Facebook recruitment: understanding research relations Prior to data collection Young K; Browne K; 39877298
CONCORDIA
4 Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA) Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello C; Cynader M; Dang-Vu T; Das S; Dixon RA; Ducharme S; Einstein G; Evans AC; Fahnestock M; Feldman H; Ferland G; Finger E; Fisk JD; Fogarty J; Fon E; Gan-Or Z; Gauthier S; Greenwood C; Henri-Bellemare C; Herrmann N; Hogan DB; Hsiung R; Itzhak I; Jacklin K; Lanctôt K; Lim A; MacKenzie I; Masellis M; Maxwell C; McAiney C; McGilton K; McLaurin J; Mihailidis A; Mohades Z; Montero-Odasso M; Morgan D; Naglie G; Nygaard H; O' Connell M; Petersen R; Pilon R; Rajah MN; Rapoport M; Roach P; Robillard JM; Rogaeva E; Rosa-Neto P; Rylett J; Sadavoy J; St George-Hyslop P; Seitz D; Smith E; Stefanovic B; Vedel I; Walker JD; Wellington C; Whitehead V; Wittich W; 39636028
HKAP
5 Research as intervention? Exploring the health and well-being of children and youth facing global adversity through participatory visual methods D' Amico M; Denov M; Khan F; Linds W; Akesson B; 27043374
EDUCATION
6 On the role of scarcity in marketing: Identifying research opportunities across the 5Ps Roux C; Goldsmith K; Cannon C; 37359269
JMSB
7 Identifying priority questions regarding rapid systematic reviews' methods: protocol for an eDelphi study Vieira AM; Szczepanik G; de Waure C; Tricco AC; Oliver S; Stojanovic J; Ribeiro PAB; Pollock D; Akl EA; Lavis J; Kuchenmuller T; Bragge P; Langer L; Bacon S; 37419644
HKAP
8 Evolution of the local climate in Montreal and Ottawa before, during and after a heatwave and the effects on urban heat islands Shu C; Gaur A; Wang L; Lacasse MA; 37263436
CONCORDIA
9 Double-Bind of Recruitment of Older Adults Into Studies of Successful Aging via Assistive Information and Communication Technologies: Mapping Review Khalili-Mahani N; Sawchuk K; 36563033
CONCORDIA
10 Editorial: Qualitative pain research: Capturing and integrating cultural, social and linguistic data Najmeh Khalili-Mahani 36506270
PERFORM
11 Patient and family engagement in patient care and research in Canadian intensive care units: a national survey Burns KEA; McDonald E; Debigaré S; Zamir N; Vasquez M; Piche-Ayotte M; Oczkowski S; 36344874
BIOLOGY
12 Toward a digital citizen lab for capturing data about alternative ways of self-managing chronic pain: An attitudinal user study Khalili-Mahani N; Woods S; Holowka EM; Pahayahay A; Roy M; 36188996
PERFORM
13 Strategies for Maintaining Friendship in Dementia Genoe MR; Fortune D; Whyte C; 35859359
CONCORDIA
14 Comparison of different severe obesity definitions in predicting future cardiometabolic risk in a longitudinal cohort of children Kakinami L; Smyrnova A; Paradis G; Tremblay A; Henderson M; 35705336
PERFORM
15 Games researchers play: conceptual advancement versus validation strategies Dubois F; R Peres-Neto P; 35193771
BIOLOGY
16 Mapping changes in the obesity stigma discourse through Obesity Canada: a content analysis Kirk SF; Forhan M; Yusuf J; Chance A; Burke K; Blinn N; Quirke S; Salas XR; Alberga A; Russell-Mayhew S; 35071667
HKAP
17 Developing a collaborative and sustainable return to work program for employees with common mental disorders: a participatory research with public and private organizations Corbière M; Mazaniello-Chézol M; Lecomte T; Guay S; Panaccio A; 34086528
PSYCHOLOGY
18 Understanding the temporal evolution of COVID-19 research through machine learning and natural language processing. Ebadi A; Xi P; Tremblay S; Spencer B; Pall R; Wong A; 33230352
ENCS
19 Methodological and clinical challenges associated with biomarkers for psychiatric disease: A scoping review. Kirkpatrick RH; Munoz DP; Khalid-Khan S; Booij L; 33221025
PSYCHOLOGY
20 A robust optimization model for tactical capacity planning in an outpatient setting Aslani N; Kuzgunkaya O; Vidyarthi N; Terekhov D; 33215335
ENCS
21 Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis Thombs BD; Levis B; Lyubenova A; Neupane D; Negeri Z; Wu Y; Sun Y; He C; Krishnan A; Vigod SN; Bhandari PM; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Barnes J; Beck CT; Bindt C; Figueiredo B; Helle N; Howard LM; Kohlhoff J; Kozinszky Z; Leonardou AA; Radoš SN; Quispel C; Rochat TJ; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; 33104415
LIBRARY
22 The Canadian Fungal Research Network: current challenges and future opportunities. Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Spribille T, Subramaniam R, Walker AK, Harris SD, Shapiro RS, Gerstein A 32717148
BIOLOGY
23 An international, Delphi consensus study to identify priorities for methodological research in behavioral trials in health research. Byrne M, McSharry J, Meade O, Lavoie KL, Bacon SL 32293510
HKAP
24 Deprescribing guidelines: An international symposium on development, implementation, research and health professional education. Farrell B, Conklin J, Dolovich L, Irving H, Maclure M, McCarthy L, Moriarty F, Pottie K, Raman-Wilms L, Reeve E, Thompson W 30241875
CONCORDIA
25 Deprescribing: Future directions for research. Thompson W, Reeve E, Moriarty F, Maclure M, Turner J, Steinman MA, Conklin J, Dolovich L, McCarthy L, Farrell B 30241876
CONCORDIA
26 Group sample sizes in nonregulated health care intervention trials described as randomized controlled trials were overly similar Thombs BD; Levis AW; Azar M; Saadat N; Riehm KE; Sanchez TA; Chiovitti MJ; Rice DB; Levis B; Fedoruk C; Lyubenova A; Malo Vázquez de Lara AL; Kloda LA; Benedetti A; Shrier I; Platt RW; Kimmelman J; 31866472
LIBRARY
27 Substance Use Research with Indigenous Communities: Exploring and Extending Foundational Principles of Community Psychology. Wendt DC, Hartmann WE, Allen J, Burack JA, Charles B, D'Amico EJ, Dell CA, Dickerson DL, Donovan DM, Gone JP, O'Connor RM, Radin SM, Rasmus SM, Venner KL, Walls ML 31365138
PSYCHOLOGY
28 Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM 28145075
PERFORM

 

Title:Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.
Authors:Khalili-Mahani NRombouts SAvan Osch MJDuff EPCarbonell FNickerson LDBecerra LDahan AEvans ACSoucy JPWise RZijdenbos APvan Gerven JM
Link:https://www.ncbi.nlm.nih.gov/pubmed/28145075?dopt=Abstract
DOI:10.1002/hbm.23516
Publication:Human brain mapping
Keywords:PK/PD modelingarterial spin labelingbiomarkersbrain chemistrydrugfunctional connectivitypharma-fMRIpharmacological neuroimagingresting state fMRItranslational research
PMID:28145075 Category:Hum Brain Mapp Date Added:2019-04-15
Dept Affiliation: PERFORM
1 McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada.
2 PERFORM Centre, Concordia University, Montreal, Canada.
3 Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
4 Institute of Psychology and Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
5 Oxford Centre for Functional MRI of the Brain, Oxford University, Oxford, United Kingdom.
6 Biospective Inc, Montreal, Quebec, Canada.
7 McLean Hospital, Belmont, Massachusetts.
8 Harvard Medical School, Boston, Massachusetts.
9 Center for Pain and the Brain, Harvard Medical School & Boston Children's Hospital, Boston, Massachusetts.
10 Department of Anesthesiology, Leiden University Medical Centre, Leiden, The Netherlands.
11 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.
12 Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
13 Centre for Human Drug Research, Leiden University Medical Centre, Leiden, The Netherlands.

Description:

Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.

Hum Brain Mapp. 2017 04;38(4):2276-2325

Authors: Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM

Abstract

A decade of research and development in resting-state functional MRI (RSfMRI) has opened new translational and clinical research frontiers. This review aims to bridge between technical and clinical researchers who seek reliable neuroimaging biomarkers for studying drug interactions with the brain. About 85 pharma-RSfMRI studies using BOLD signal (75% of all) or arterial spin labeling (ASL) were surveyed to investigate the acute effects of psychoactive drugs. Experimental designs and objectives include drug fingerprinting dose-response evaluation, biomarker validation and calibration, and translational studies. Common biomarkers in these studies include functional connectivity, graph metrics, cerebral blood flow and the amplitude and spectrum of BOLD fluctuations. Overall, RSfMRI-derived biomarkers seem to be sensitive to spatiotemporal dynamics of drug interactions with the brain. However, drugs cause both central and peripheral effects, thus exacerbate difficulties related to biological confounds, structured noise from motion and physiological confounds, as well as modeling and inference testing. Currently, these issues are not well explored, and heterogeneities in experimental design, data acquisition and preprocessing make comparative or meta-analysis of existing reports impossible. A unifying collaborative framework for data-sharing and data-mining is thus necessary for investigating the commonalities and differences in biomarker sensitivity and specificity, and establishing guidelines. Multimodal datasets including sham-placebo or active control sessions and repeated measurements of various psychometric, physiological, metabolic and neuroimaging phenotypes are essential for pharmacokinetic/pharmacodynamic modeling and interpretation of the findings. We provide a list of basic minimum and advanced options that can be considered in design and analyses of future pharma-RSfMRI studies. Hum Brain Mapp 38:2276-2325, 2017. © 2017 Wiley Periodicals, Inc.

PMID: 28145075 [PubMed - indexed for MEDLINE]





BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University