| Keyword search (4,163 papers available) | ![]() |
"psychiatry" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial | McAnulty C; Lavoie P; Cyr S; Lavin P; Elkrief L; Richard-Devantoy S; Rizkallah E; Lespérance P; Gamin N; Lembke A; Jutras-Aswad D; Greenway K; Garel N; | 41857871 PSYCHOLOGY |
| 2 | Large language models deconstruct the clinical intuition behind diagnosing autism | Stanley J; Rabot E; Reddy S; Belilovsky E; Mottron L; Bzdok D; | 40147442 ENCS |
| 3 | Effect of mindfulness-based programmes on elite athlete mental health: a systematic review and meta-analysis | Myall K; Montero-Marin J; Gorczynski P; Kajee N; Syed Sheriff R; Bernard R; Harriss E; Kuyken W; | 36223914 EDUCATION |
| 4 | Depression Screening and Health Outcomes in Children and Adolescents: A Systematic Review | Roseman M; Saadat N; Riehm KE; Kloda LA; Boruff J; Ickowicz A; Baltzer F; Katz LY; Patten SB; Rousseau C; Thombs BD; | 28851234 LIBRARY |
| 5 | Striking a balance: triage and crisis intervention models within the pediatric emergency room | Laporte N; Hechtman L; Rousseau C; Greenfield B; | 37920538 PSYCHOLOGY |
| 6 | Teleconsultations for mental health: Recommendations from a Delphi panel | Manera V; Partos C; Beauchet O; Benoit M; Dupetit B; Elbaum J; Fabre R; Gindt M; Gros A; Guerchouche R; Klöppel S; König A; Martin A; Mouton A; Pancrazi MP; Politis A; Robert G; Sacco G; Sacconi S; Sawchuk K; Solari F; Thiebot L; Trimarchi PD; Zeghari R; Robert P; | 37655117 ENCS |
| 7 | Gender and sex in eating disorders: A narrative review of the current state of knowledge, research gaps, and recommendations | Breton É; Juster RP; Booij L; | 36840375 PSYCHOLOGY |
| 8 | Methodological and clinical challenges associated with biomarkers for psychiatric disease: A scoping review. | Kirkpatrick RH; Munoz DP; Khalid-Khan S; Booij L; | 33221025 PSYCHOLOGY |
| 9 | Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis | Thombs BD; Levis B; Lyubenova A; Neupane D; Negeri Z; Wu Y; Sun Y; He C; Krishnan A; Vigod SN; Bhandari PM; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Barnes J; Beck CT; Bindt C; Figueiredo B; Helle N; Howard LM; Kohlhoff J; Kozinszky Z; Leonardou AA; Radoš SN; Quispel C; Rochat TJ; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; | 33104415 LIBRARY |
| Title: | Large language models deconstruct the clinical intuition behind diagnosing autism | ||||
| Authors: | Stanley J, Rabot E, Reddy S, Belilovsky E, Mottron L, Bzdok D | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40147442/ | ||||
| DOI: | 10.1016/j.cell.2025.02.025 | ||||
| Publication: | Cell | ||||
| Keywords: | LLM; NLP; autism; deep learning; health records; language models; neural networks; psychiatry; | ||||
| PMID: | 40147442 | Category: | Date Added: | 2025-03-28 | |
| Dept Affiliation: |
ENCS
1 Mila - Québec Artificial Intelligence Institute, Montréal, QC H2S3H1, Canada; The Neuro - Montréal Neurological Institute (MNI), McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, School of Computer Science, McGill University, Montréal, QC H3A2B4, Canada. 2 Research Center, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Ile-de-Montréal (CIUSSS-NIM), Montréal, QC H4K1B3, Canada; Université de Montréal, Montréal, QC H3C3J7, Canada. 3 Mila - Québec Artificial Intelligence Institute, Montréal, QC H2S3H1, Canada. 4 Mila - Québec Artificial Intelligence Institute, Montréal, QC H2S3H1, Canada; Department of Computer Science and Software Engineering, Concordia University, Montreal, QC H3G 1M8, Canada. 5 Mila - Québec Artificial Intelligence Institute, Montréal, QC H2S3H1, Canada; The Neuro - Montréal Neurological Institute (MNI), McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, S |
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Description: |
Efforts to use genome-wide assays or brain scans to diagnose autism have seen diminishing returns. Yet the clinical intuition of healthcare professionals, based on longstanding first-hand experience, remains the gold standard for diagnosis of autism. We leveraged deep learning to deconstruct and interrogate the logic of expert clinician intuition from clinical reports to inform our understanding of autism. After pre-training on hundreds of millions of general sentences, we finessed large language models (LLMs) on >4,000 free-form health records from healthcare professionals to distinguish confirmed versus suspected autism cases. By introducing an explainability strategy, our extended language model architecture could pin down the most salient single sentences in what drives clinical thinking toward correct diagnoses. Our framework flagged the most autism-critical DSM-5 criteria to be stereotyped repetitive behaviors, special interests, and perception-based behaviors, which challenges today's focus on deficits in social interplay, suggesting necessary revision of long-trusted diagnostic criteria in gold-standard instruments. |



