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"pre-implantation embryo" Keyword-tagged Publications:

Title Authors PubMed ID
1 Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring. Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S 33596408
PERFORM

 

Title:Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.
Authors:Lismer A,  Dumeaux V,  Lafleur C,  Lambrot R,  Brind'Amour J,  Lorincz MC,  Kimmins S
Link:https://www.ncbi.nlm.nih.gov/pubmed/33596408
DOI:10.1016/j.devcel.2021.01.014
Publication:Developmental cell
Keywords:H3K4me3;  chromatin;  diet;  epigenetic inheritance;  folate deficiency;  pre-implantation embryo;  sperm; 
PMID:33596408 Category:Dev Cell Date Added:2021-02-18
Dept Affiliation: PERFORM
1 Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada.
2 PERFORM Center, Concordia University, Montreal, QC H4B 1R6, Canada.
3 Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC H9X 3V9, Canada.
4 Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
5 Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC H9X 3V9, Canada. Electronic address: sarah.kimmins@mcgill.ca.

Description:

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Dev Cell. 2021 Feb 15; :

Authors: Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S

Abstract

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and development. Here, we demonstrate that a folate-deficient (FD) diet alters histone H3 lysine 4 trimethylation (H3K4me3) in sperm at developmental genes and putative enhancers. A subset of H3K4me3 alterations in sperm are retained in the pre-implantation embryo and associated with deregulated embryonic gene expression. Using a genetic mouse model in which sires have pre-existing altered H3K4me2/3 in sperm, we show that a FD diet exacerbates alterations in sperm H3K4me3 and embryonic gene expression, leading to an increase in developmental defect severity. These findings imply that paternal H3K4me3 is transmitted to the embryo and influences gene expression and development. It further suggests that epigenetic errors can accumulate in sperm to worsen offspring developmental outcomes.

PMID: 33596408 [PubMed - as supplied by publisher]




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