PERFORM Publications

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Title		Authors	PubMed ID
1	Improved electrical performance of PDMS and PEDOT: PSS composites with MWCNT and AgNP particles	Shafagh SH; Deen I; Packirisamy M;	41424586 ENCS
2	Light-Activated Micromotors in Air Propelled by Thermal Convection	Mena-Giraldo P; Mandl GA; Quezada-Novoa V; Garcia-Henao C; Bondon N; Hazlett MJ; Capobianco JA;	40964823 CNSR
3	A synthetic model of bioinspired liposomes to study cancer-cell derived extracellular vesicles and their uptake by recipient cells	López RR; Ben El Khyat CZ; Chen Y; Tsering T; Dickinson K; Bustamante P; Erzingatzian A; Bartolomucci A; Ferrier ST; Douanne N; Mounier C; Stiharu I; Nerguizian V; Burnier JV;	40069225 ENCS
4	Long-lasting antimicrobial effect of multipurpose ZnO nanoparticle-loaded dental resins enhanced by blue light photodynamic therapy	Leite ML; Comeau P; Zaghwan A; Shen Y; Manso AP;	39765362 ENCS
5	3D bioheat transfer mapping reveals nanomagnetic particles effectiveness in radiofrequency hyperthermia breast cancer treatment comparing to experimental study	Kavousi M; Saadatmand E; Masoumbeigi M; Mahdavi R; Riyahi Alam N;	39557504 PHYSICS
6	Non-invasive paper-based sensors containing rare-earth-doped nanoparticles for the detection of D-glucose	López-Peña G; Ortiz-Mansilla E; Arranz A; Bogdan N; Manso-Silván M; Martín Rodríguez E;	38729020 CHEMBIOCHEM
7	Tailoring plasmonic sensing strategies for the rapid and sensitive detection of hypochlorite in swimming water samples	Sadiq Z; Al-Kassawneh M; Safiabadi Tali SH; Jahanshahi-Anbuhi S;	38451315 ENCS
8	Janus Micromotors for Photophoretic Motion and Photon Upconversion Applications Using a Single Near-Infrared Wavelength	Mena-Giraldo P; Kaur M; Maurizio SL; Mandl GA; Capobianco JA;	38197400 CHEMBIOCHEM
9	SiCNFe Ceramics as Soft Magnetic Material for MEMS Magnetic Devices: A Mössbauer Study	Stiharu I; Andronenko S; Zinnatullin A; Vagizov F;	37241549 PHYSICS
10	Gold Nanoparticles-Based Colorimetric Assays for Environmental Monitoring and Food Safety Evaluation	Sadiq Z; Safiabadi Tali SH; Hajimiri H; Al-Kassawneh M; Jahanshahi-Anbuhi S;	36629748 ENCS
11	Utilization of a biosurfactant foam/nanoparticle mixture for treatment of oil pollutants in soil	Vu KA; Mulligan CN;	35834082 ENCS
12	Remediation of oil-contaminated soil using Fe/Cu nanoparticles and biosurfactants	Vu KA; Mulligan CN;	35361056 ENCS
13	Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing	Huang HY; Skripka A; Zaroubi L; Findlay BL; Vetrone F; Skinner C; Oh JK; Cuccia LA;	35019380 CHEMBIOCHEM
14	Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.	Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG	33455300 CHEMBIOCHEM
15	Using intracellular plasmonics to characterize nanomorphology in human cells.	Sohrabi Kashani A, Piekny A, Packirisamy M	33365137 BIOLOGY
16	Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.	Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG	31820915 CHEMBIOCHEM
17	The Key Role of Intrinsic Lifetime Dynamics from Upconverting Nanosystems in Multiemission Particle Velocimetry	Tessitore G; Maurizio SL; Sabri T; Skinner CD; Capobianco JA;	32924221 CNSR
18	Exploring the biophysicochemical alteration of green alga Asterococcus superbus interactively affected by nanoparticles, triclosan and illumination.	Xin X, Huang G, An C, Lu C, Xiong W	32473326 ENCS
19	Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles.	Kilin V, Campargue G, Fureraj I, Sakong S, Sabri T, Riporto F, Vieren A, Mugnier Y, Mas C, Staedler D, Collins JM, Bonacina L, Vogel A, Capobianco JA, Wolf JP	32282184 CNSR
20	Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer.	López RR, Ocampo I, Sánchez LM, Alazzam A, Bergeron KF, Camacho-León S, Mounier C, Stiharu I, Nerguizian V	32106424 ENCS

Title:	Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.
Authors:	Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33455300
DOI:	10.1021/acsbiomaterials.0c00896
Publication:	ACS biomaterials science & engineering
Keywords:	directed self-assembly; drug delivery; microfluidics; nanoparticles; reduction-responsive block copolymers;
PMID:	33455300	Category:	ACS Biomater Sci Eng	Date Added:	2021-01-20
Dept Affiliation:	CHEMBIOCHEM 1 Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada. 2 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada. 3 Department of Biochemistry and Microbiology, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.

Description:

Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

ACS Biomater Sci Eng. 2020 Sep 14; 6(9):5069-5083

Authors: Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

Abstract

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of the physicochemical properties of GSH-responsive PNPs containing cleavable disulfide groups in two different locations (core and interface, DualM PNPs). In this paper, we employ a two-phase gas-liquid microfluidic reactor for the flow-directed manufacturing of paclitaxel-loaded or DiI-loaded DualM PNPs (PAX-PNPs or DiI-PNPs, where DiI is a fluorescent drug surrogate dye). We find that both PAX-PNPs and DiI-PNPs exhibit similar flow-tunable sizes, morphologies, and internal structures to those previously described for empty DualM PNPs. Fluorescent imaging of DiI-PNP formulations shows that microfluidic manufacturing greatly improves the homogeneity of drug dispersion within the PNP population compared to standard bulk microprecipitation. Encapsulation of PAX in DualM PNPs significantly increases its selectivity to cancerous cells, with various PAX-PNP formulations showing higher cytotoxicity against cancerous MCF-7 cells than against non-cancerous HaCaT cells, in contrast to free PAX, which showed similar cytotoxicity in the two cell lines. In addition, the characterization of DualM PNP formulations formed at various microfluidic flow rates reveals that critical figures of merit for drug delivery function-including encapsulation efficiencies, GSH-triggered release rates, rates of cell uptake, cytotoxicities, and selectivity to cancerous cells-exhibit microfluidic flow tunability that mirrors trends in PNP size. These results highlight the potential of two-phase microfluidic manufacturing for controlling both structure and drug delivery function of biological stimuli-responsive nanomedicines toward improved therapeutic outcomes.

PMID: 33455300 [PubMed - in process]

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