Keyword search (4,163 papers available)

"nale" Keyword-tagged Publications:

Title Authors PubMed ID
1 Identifying climate change refugia for South American biodiversity Sales LP; Pires MM; 36919472
BIOLOGY
2 How Will COVID-19 Alter the Politics of Long-Term Care? A Comparative Policy Analysis of Popular Reform Options Patrik Marier 34711297
CONCORDIA
3 Drug discovery and chemical probing in Drosophila. Millet-Boureima C, Selber-Hnatiw S, Gamberi C 32551911
BIOLOGY

 

Title:Drug discovery and chemical probing in Drosophila.
Authors:Millet-Boureima CSelber-Hnatiw SGamberi C
Link:https://www.ncbi.nlm.nih.gov/pubmed/32551911?dopt=Abstract
DOI:10.1139/gen-2020-0037
Publication:Genome
Keywords:Drosophilacriblage de composésdrug discoverydrug screenscouverte de médicamentsmaladies orphelinesmodèles animauxorphan diseasepathway probingpolycystic kidney diseasepolykystose rénalesondage des sentierswhole-animal models
PMID:32551911 Category:Genome Date Added:2020-06-20
Dept Affiliation: BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

Drug discovery and chemical probing in Drosophila.

Genome. 2020 Jun 18;:

Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Abstract

Flies are increasingly utilized in drug discovery and chemical probing in vivo, which are novel technologies complementary to genetic probing in fundamental biological studies. Excellent genetic conservation, small size, short generation time and over one hundred years of genetics make Drosophila an attractive model for rapid assay readout and use of analytical amounts of compound, enabling the experimental iterations needed in early drug development at a fraction of time and costs. Here, we describe an effective drug-testing pipeline using adult flies that can be easily implemented to study several disease models and different genotypes to discover novel molecular insight, probes, quality lead compounds, and develop novel prototype drugs.

PMID: 32551911 [PubMed - as supplied by publisher]





BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University