Keyword search (4,164 papers available)

"mental disorder" Keyword-tagged Publications:

Title Authors PubMed ID
1 Should Burnout Be Conceptualized as a Mental Disorder? Nadon L; De Beer LT; Morin AJS; 35323401
PSYCHOLOGY
2 Developing a collaborative and sustainable return to work program for employees with common mental disorders: a participatory research with public and private organizations Corbière M; Mazaniello-Chézol M; Lecomte T; Guay S; Panaccio A; 34086528
PSYCHOLOGY
3 Digital Game Interventions for Youth Mental Health Services (Gaming My Way to Recovery): Protocol for a Scoping Review. Ferrari M, McIlwaine SV, Reynolds JA, Archie S, Boydell K, Lal S, Shah JL, Henderson J, Alvarez-Jimenez M, Andersson N, Boruff J, Nielsen RKL, Iyer SN 32579117
CONCORDIA
4 Stakeholders' Role and Actions in the Return-to-Work Process of Workers on Sick-Leave Due to Common Mental Disorders: A Scoping Review Corbière M; Mazaniello-Chézol M; Bastien MF; Wathieu E; Bouchard R; Panaccio A; Guay S; Lecomte T; 31673934
PSYCHOLOGY
5 Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts. Milev MP, Graziano C, Karall D, Kuper WFE, Al-Deri N, Cordelli DM, Haack TB, Danhauser K, Iuso A, Palombo F, Pippucci T, Prokisch H, Saint-Dic D, Seri M, Stanga D, Cenacchi G, van Gassen KLI, Zschocke J, Fauth C, Mayr JA, Sacher M, van Hasselt PM 30120216
BIOLOGY
6 TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins. Sacher M, Shahrzad N, Kamel H, Milev MP 30152084
BIOLOGY

 

Title:TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.
Authors:Sacher M,  Shahrzad N,  Kamel H,  Milev MP
Link:https://www.ncbi.nlm.nih.gov/pubmed/30152084?dopt=Abstract
DOI:10.1111/tra.12615
Publication:Traffic (Copenhagen, Denmark)
Keywords:Golgi;  Rab;  TRAPP;  guanine nucleotide exchange factor;  intellectual deficit;  membrane traffic;  muscular dystrophy;  neurodevelopmental disorders;  secretory pathway;  variants; 
PMID:30152084 Category:Traffic Date Added:2019-06-07
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, Montreal, Quebec, Canada.
2 Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
3 Department of Medicine, University of California, San Francisco, California.

Description:

TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.

Traffic. 2019 01;20(1):5-26

Authors: Sacher M, Shahrzad N, Kamel H, Milev MP

Abstract

The movement of proteins between cellular compartments requires the orchestrated actions of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors (SNAREs) and so-called tethering factors. One such tethering factor is called TRAnsport Protein Particle (TRAPP), and in humans, TRAPP proteins are distributed into two related complexes called TRAPP II and III. Although thought to act as a single unit within the complex, in the past few years it has become evident that some TRAPP proteins function independently of the complex. Consistent with this, variations in the genes encoding these proteins result in a spectrum of human diseases with diverse, but partially overlapping, phenotypes. This contrasts with other tethering factors such as COG, where variations in the genes that encode its subunits all result in an identical phenotype. In this review, we present an up-to-date summary of all the known disease-related variations of genes encoding TRAPP-associated proteins and the disorders linked to these variations which we now call TRAPPopathies.

PMID: 30152084 [PubMed - in process]




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