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PubMed Publications| Keyword search (4,163 papers available) |  |
"melatonin" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Radiosynthesis and In Vivo Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors | Bdair H; Singleton TA; Ross K; Jolly D; Kang MS; Aliaga A; Tuznik M; Kaur T; Yous S; Soucy JP; Massarweh G; Scott PJH; Koeppe R; Spadoni G; Bedini A; Rudko DA; Gobbi G; Benkelfat C; Rosa-Neto P; Brooks AF; Kostikov A; | 35420022 PERFORM |
| 2 | Empowering Melatonin Therapeutics with Drosophila Models | Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C; | 34698120 BIOLOGY |
| 3 | Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease. | Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C; | 33238462 BIOLOGY |
| Title: | Empowering Melatonin Therapeutics with Drosophila Models | ||||
| Authors: | Millet-Boureima C, Ennis CC, Jamison J, McSweeney S, Park A, Gamberi C | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34698120/ | ||||
| DOI: | 10.3390/diseases9040067 | ||||
| Publication: | Diseases (Basel, Switzerland) | ||||
| Keywords: | Drosophila; PKD; longevity; melatonin; neurodegeneration; oxidative stress; | ||||
| PMID: | 34698120 | Category: | Date Added: | 2021-10-26 | |
| Dept Affiliation: |
BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada. 2 Department of Biology, Coastal Carolina University, Conway, SC 29528-6054, USA. |
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Description: |
Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis and discover new drugs. Here, we review the multiple functions of melatonin through the lens of functional conservation and model organism research to empower potential melatonin therapeutics to treat neurodegenerative and renal diseases. |
