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PubMed Publications| Keyword search (4,163 papers available) |  |
"longevity" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast | Leonov A; Feldman R; Piano A; Arlia-Ciommo A; Junio JAB; Orfanos E; Tafakori T; Lutchman V; Mohammad K; Elsaser S; Orfali S; Rajen H; Titorenko VI; | 35937500 BIOLOGY |
| 2 | Empowering Melatonin Therapeutics with Drosophila Models | Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C; | 34698120 BIOLOGY |
| 3 | Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease. | Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C; | 33238462 BIOLOGY |
| 4 | Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast. | Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É, Titorenko VI | 32577164 BIOLOGY |
| 5 | Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome. | Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI | 25839782 MASSSPEC |
| 6 | Some Metabolites Act as Second Messengers in Yeast Chronological Aging. | Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI | 29543708 BIOLOGY |
| Title: | Empowering Melatonin Therapeutics with Drosophila Models | ||||
| Authors: | Millet-Boureima C, Ennis CC, Jamison J, McSweeney S, Park A, Gamberi C | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34698120/ | ||||
| DOI: | 10.3390/diseases9040067 | ||||
| Publication: | Diseases (Basel, Switzerland) | ||||
| Keywords: | Drosophila; PKD; longevity; melatonin; neurodegeneration; oxidative stress; | ||||
| PMID: | 34698120 | Category: | Date Added: | 2021-10-26 | |
| Dept Affiliation: |
BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada. 2 Department of Biology, Coastal Carolina University, Conway, SC 29528-6054, USA. |
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Description: |
Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis and discover new drugs. Here, we review the multiple functions of melatonin through the lens of functional conservation and model organism research to empower potential melatonin therapeutics to treat neurodegenerative and renal diseases. |
