PERFORM Publications

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Title		Authors	PubMed ID
1	Perceived Partner Responsiveness is Associated with Longitudinal Changes in Circulating Inflammatory Biomarkers Among Caregiving Mothers in Midlife	Gouin JP; Sánchez-Carro Y; Cruz IP; MacNeil S;	41876038 PSYCHOLOGY
2	Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact	Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H;	41358624 PSYCHOLOGY
3	The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss	Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;	40831565 SOH
4	Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?	Turner L; Wanasinghe AI; Brunori P; Santosa S;	40533358 SOH
5	Sex Differences in the Association Between Subjective Social Status and Imaging Markers of Cardiac Inflammation and Fibrosis	Sánchez-Carro Y; Moukarzel M; Friedrich MG; Gouin JP; Luu JM;	40471966 PSYCHOLOGY
6	Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats	Meyer C; Schoettner K; Amir S;	39624490 PSYCHOLOGY
7	Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus	Plissonneau C; Santosa S;	39553621 SOH
8	Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium	Bamisi O; Oluwalabani AO; Arogundade TT; Olajide OJ;	39303770 PSYCHOLOGY
9	Cancer anorexia-cachexia syndrome is characterized by more than one inflammatory pathway	Bruno Gagnon	38481033 HKAP
10	Editorial: Neuroepigenetics and biological mechanisms of stress-induced socio-cognitive changes	Daniels WMU; Ajonijebu DC; Olajide OJ;	38445046 CSBN
11	Changes in Purpose in Life and Low-Grade Chronic Inflammation Across Older Adulthood	Giannis I; Wrosch C; Herriot H; Gouin JP;	37643057 CONCORDIA
12	Efficacy of topical versus oral analgesic medication compared to a placebo in injured athletes: A systematic review with meta-analysis	Nudo S; Jimenez-Garcia JA; Dover G;	37278322 CONCORDIA
13	Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders?	Breton E; Fotso Soh J; Booij L;	35594735 PSYCHOLOGY
14	Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates	Cossette C; Chourey S; Ye Q; Reddy CN; Wang R; Poulet S; Slobodchikova I; Vuckovic D; Rokach J; Powell WS;	35158054 PERFORM
15	Altered immunometabolism in adipose tissue: a major contributor to the ageing process?	Delaney KZ; Gillespie ZE; Murphy J; Wang C;	34159597 PERFORM
16	Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids	Turner L; Santosa S;	33979430 PERFORM
17	Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.	Olajide OJ, Suvanto ME, Chapman CA	33495355 PSYCHOLOGY
18	A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.	Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S	32926866 PERFORM
19	Inhibitory potentials of Cymbopogon citratus oil against aluminium-induced behavioral deficits and neuropathology in rats.	Temitayo GI, Olawande B, Emmanuel YO, Timothy AT, Kehinde O, Susan LF, Ezra L, Joseph OO	32839358 PSYCHOLOGY
20	In Vivo Solid-Phase Microextraction for Sampling of Oxylipins in Brain of Awake, Moving Rats	Napylov A; Reyes-Garces N; Gomez-Rios G; Olkowicz M; Lendor S; Monnin C; Bojko B; Hamani C; Pawliszyn J; Vuckovic D;	31697450 CHEMBIOCHEM
21	Interpersonal capitalization moderates the associations of chronic caregiving stress and depression with inflammation.	Gouin JP, Wrosch C, McGrath J, Booij L	31744782 PSYCHOLOGY
22	Attachment style and changes in systemic inflammation following migration to a new country among international students.	Gouin JP, MacNeil S	30406717 PERFORM
23	In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.	Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS	28476332 PERFORM
24	From neutrophils to macrophages: differences in regional adipose tissue depots.	Dam V, Sikder T, Santosa S	26667065 PERFORM
25	Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII-independent manner.	Stopnicki B, Blain M, Cui QL, Kennedy TE, Antel JP, Healy LM, Darlington PJ	30444064 PERFORM

Title:	Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII-independent manner.
Authors:	Stopnicki B, Blain M, Cui QL, Kennedy TE, Antel JP, Healy LM, Darlington PJ
Link:	https://www.ncbi.nlm.nih.gov/pubmed/30444064?dopt=Abstract
DOI:	10.1002/glia.23503
Publication:	Glia
Keywords:	GFAP; T cell; astrocyte; caspase; cytoskeleton; granzyme B; neuroinflammation;
PMID:	30444064	Category:	Glia	Date Added:	2019-04-15
Dept Affiliation:	PERFORM 1 Department of Exercise Science, Department of Biology, PERFORM Centre, Concordia University, Montréal, Quebec, Canada. 2 Department of Neurology and Neurosurgery, Montreal Neurological Institute, and McGill University, Montreal, Quebec, Canada. 3 Neuroimmunology Unit, McGill University, Montréal, Quebec, Canada.

Description:

Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII-independent manner.

Glia. 2019 04;67(4):582-593

Authors: Stopnicki B, Blain M, Cui QL, Kennedy TE, Antel JP, Healy LM, Darlington PJ

Abstract

During inflammatory processes of the central nervous system, helper T cells have the capacity to cross the blood-brain barrier and injure or kill neural cells through cytotoxic mechanisms. Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is part of the astrocyte cytoskeleton that can become fragmented in neuroinflammatory conditions. The mechanism of action by which helper T cells with cytotoxic properties injure astrocytes is not completely understood. Primary human astrocytes were obtained from fetal brain tissue. Human helper (CD4+ ) T cells were isolated from peripheral blood mononuclear cells and activated with the superantigen staphylococcal enterotoxin E (SEE). Granzyme B was detected by enzyme linked immunosorbent assay and intracellular flow cytometry. GFAP fragmentation was monitored by western blotting. Cell death was monitored by lactic acid dehydrogenase release and terminal biotin-dUTP nick labeling (TUNEL). Astrocyte migration was monitored by scratch assay. Adult human oligodendrocytes were cultured with sublethally injured astrocytes to determine support function. Helper T cells activated with SEE expressed granzyme B but not perforin. Helper T cells released granzyme B upon contact with astrocytes and caused GFAP fragmentation in a caspase-dependent, MHCII-independent manner. Sublethally injured astrocytes were not apoptotic; however, their processes were thin and elongated, their migration was attenuated, and their ability to support oligodendrocytes was reduced in vitro. Helper T cells can release granzyme B causing sublethal injury to astrocytes, which compromises the supportive functions of astrocytes. Blocking these pathways may lead to improved resolution of neuroinflammatory lesions.

PMID: 30444064 [PubMed - in process]

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