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PubMed Publications| Keyword search (4,163 papers available) |  |
"genomics" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome | Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G; | 41794383 HKAP |
| 2 | Season and city shape urban bioaerosol composition beyond vegetation and socioeconomic gradients | Poirier S; Rondeau-Leclaire J; Faticov M; Roy A; Lajeunesse G; Lucier JF; Tardif S; Kembel SW; Ziter C; Laprise C; Paquette A; Girard C; Laforest-Lapointe I; | 41785576 BIOLOGY |
| 3 | Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in em Caenorhabditis elegans, /em challenges a proposed role in heme trafficking | Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ; | 41504601 BIOLOGY |
| 4 | Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood | Won Kang JR; Kim YJ; Skead K; Soave D; Evans J; Bruat V; Harwood MP; Morris Q; Matovu E; Mulindwa J; Noyes H; McLeod A; Hazelhurst S; Lombard Z; Ramsay M; Fave MJ; Awadalla P; | 41282824 BIOLOGY |
| 5 | Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance | Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P; | 39920830 BIOLOGY |
| 6 | Widespread admixture blurs population structure and confounds Lake Trout (Salvelinus namaycush) conservation even in the genomic era | Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ; | 39730611 BIOLOGY |
| 7 | Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring | Kuzmin E; Baker TM; Lesluyes T; Monlong J; Abe KT; Coelho PP; Schwartz M; Del Corpo J; Zou D; Morin G; Pacis A; Yang Y; Martinez C; Barber J; Kuasne H; Li R; Bourgey M; Fortier AM; Davison PG; Omeroglu A; Guiot MC; Morris Q; Kleinman CL; Huang S; Gingras AC; Ragoussis J; Bourque G; Van Loo P; Park M; | 38517886 BIOLOGY |
| 8 | Editorial: Computational systems immunovirology | Zarei Ghobadi M; Teymoori-Rad M; Selvaraj G; Wei DQ; | 37475870 CHEMBIOCHEM |
| 9 | Rethinking microbial infallibility in the metagenomics era | O' Malley MA; Walsh DA; | 34160589 BIOLOGY |
| 10 | ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance | Lismer A; Lambrot R; Lafleur C; Dumeaux V; Kimmins S; | 34159325 PERFORM |
| 11 | A Novel Freshwater to Marine Evolutionary Transition Revealed within Methylophilaceae Bacteria from the Arctic Ocean | Ramachandran A; McLatchie S; Walsh DA; | 34154421 BIOLOGY |
| 12 | Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics | Evdokias G; Semper C; Mora-Ochomogo M; Di Falco M; Nguyen TTM; Savchenko A; Tsang A; Benoit-Gelber I; | 34064722 BIOLOGY |
| 13 | Core Competencies in Cancer Genomics for Healthcare Professionals: Results From a Systematic Literature Review and a Delphi Process. | Hoxhaj I, Tognetto A, Acampora A, Stojanovic J, Boccia S | 33442861 HKAP |
| 14 | Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes. | Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Pierella Karlusich JJ, Pelletier E, Morlon H, Bowler C, Blanc G | 33419955 BIOLOGY |
| 15 | Genome Sequence Resource of Bacillus velezensis EB14, a native endophytic bacterial strain with biocontrol potential against the poplar stem canker causative pathogen, Sphaerulina musiva. | Naik S, Tsang A, Ramanan US, Dayanandan S | 33263425 BIOLOGY |
| 16 | Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors. | Manjunath M; Yan J; Youn Y; Drucker KL; Kollmeyer TM; McKinney AM; Zazubovich V; Zhang Y; Costello JF; Eckel-Passow J; Selvin PR; Jenkins RB; Song JS; | 33130899 PHYSICS |
| 17 | Sediment Metagenomes as Time Capsules of Lake Microbiomes. | Garner RE; Gregory-Eaves I; Walsh DA; | 33148818 BIOLOGY |
| 18 | Size reductions and genomic changes within two generations in wild walleye populations: associated with harvest? | Bowles E, Marin K, Mogensen S, MacLeod P, Fraser DJ | 32684951 CONCORDIA |
| 19 | Plasma levels of one-carbon metabolism nutrients in women with anorexia nervosa | Burdo J; Booij L; Kahan E; Thaler L; Israël M; Agellon LB; Nitschmann E; Wykes L; Steiger H; | 32427359 PSYCHOLOGY |
| 20 | Diversity, evolution, and classification of virophages uncovered through global metagenomics. | Paez-Espino D, Zhou J, Roux S, Nayfach S, Pavlopoulos GA, Schulz F, McMahon KD, Walsh D, Woyke T, Ivanova NN, Eloe-Fadrosh EA, Tringe SG, Kyrpides NC | 31823797 BIOLOGY |
| 21 | Enzymes of early-diverging, zoosporic fungi. | Lange L, Barrett K, Pilgaard B, Gleason F, Tsang A | 31309267 CSFG |
| 22 | Chaco Canyon Dig Unearths Ethical Concerns. | Claw KG, Lippert D, Bardill J, Cordova A, Fox K, Yracheta JM, Bader AC, Bolnick DA, Malhi RS, TallBear K, Garrison NA | 29745246 CONCORDIA |
| 23 | Genetics of mating in members of the Chaetomiaceae as revealed by experimental and genomic characterization of reproduction in Myceliophthora heterothallica. | Hutchinson MI, Powell AJ, Tsang A, O'Toole N, Berka RM, Barry K, Grigoriev IV, Natvig DO | 26608618 CSFG |
| 24 | An Evolutionarily Conserved Transcriptional Activator-Repressor Module Controls Expression of Genes for D-Galacturonic Acid Utilization in Aspergillus niger. | Niu J, Alazi E, Reid ID, Arentshorst M, Punt PJ, Visser J, Tsang A, Ram AF | 28049705 CSFG |
| 25 | Thermostable xylanases from thermophilic fungi and bacteria: Current perspective. | Chadha BS, Kaur B, Basotra N, Tsang A, Pandey A | 30679061 CSFG |
| Title: | Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome | ||||
| Authors: | Wannaiampikul S, Lee B, Chen J, Prentice KJ, Ayansola R, Xu A, Santosa S, Pantopoulos K, Sweeney G | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41794383/ | ||||
| DOI: | 10.1016/j.jnutbio.2026.110327 | ||||
| Publication: | The Journal of nutritional biochemistry | ||||
| Keywords: | Host-Microbiome Interaction; Metabolic Syndrome; Metagenomics; Obesity; Serum Metabolomics; Thai Population; | ||||
| PMID: | 41794383 | Category: | Date Added: | 2026-03-08 | |
| Dept Affiliation: |
HKAP
1 Thai Canada Research Centre, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Thailand.; Division of Internal Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Ongkharak, Thailand. 2 Division of Internal Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Ongkharak, Thailand. 3 State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, and Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, P.R. China. 4 Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Banting and Best Diabetes Centre, Toronto, Canada. 5 Department of Biology, York University, Toronto, Canada. 6 State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China. 7 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada. 8 Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada. 9 Thai Canada Research Centre, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Thailand.; Department of Biology, York University, Toronto, Canada.. Electronic address: gsweeney@yorku.ca. |
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Description: |
Background: Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite recognition of the gut microbiome's role in metabolic health, there remains scope for defining association of unique microbes with clinical status. Unique genetic, dietary, and lifestyle factors may influence gut microbial composition and circulating metabolites, and consequently susceptibility to MetS. By identifying specific microbial and metabolomic signatures associated with MetS, we aim to uncover potential targets for reducing the disease burden. Methods: We correlate comprehensive clinical parameters with fecal metagenomics and untargeted serum metabolomics to delineate population-specific characteristics from 142 individuals with MetS (N=97) or control (CTRL; N=45). Results: Microbiome species-level alpha diversity was reduced in MetS compared to CTRL. After adjustment for sex, age, BMI, and intensity of statin usage, we identified 20 MetS-related species. A co-abundant network analysis revealed Eubacterium eligens, enriched in the CTRL population, with the highest node degree. Serum metabolomics identified 106 significantly differentially regulated metabolites. N-arachidonoyl dopamine (NADA), an endocannabinoid implicated in GABAergic signaling, was the most significantly altered, enriched in CTRL and correlated with E. Eligens. sPLS-DA modeling revealed that E. eligens and D. formicigenerans species cluster together with metabolites NADA and tetrahydrocorticosterone (THB), representing defining characteristics distinguishing MetS in this population. Conclusions: Our data reveal a distinct multi-omic signature of MetS, characterized by a significant reduction in E. eligens and D. formicigenerans abundance, and in circulating NADA and THB levels. |
