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PubMed Publications| Keyword search (4,163 papers available) |  |
"gene regulation" Keyword-tagged Publications:
| Title: | Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database | ||||
| Authors: | Rurak GM, Simard S, Freitas-Andrade M, Lacoste B, Charih F, Van Geel A, Stead J, Woodside B, Green JR, Coppola G, Salmaso N | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35108542/ | ||||
| DOI: | 10.1016/j.celrep.2022.110310 | ||||
| Publication: | Cell reports | ||||
| Keywords: | astrocyte; cortex; development; females; gene regulation; glia; sex; systems biology; translatome; | ||||
| PMID: | 35108542 | Category: | Date Added: | 2022-02-03 | |
| Dept Affiliation: |
ENCS
1 Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada. 2 Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada. 3 Department of Systems and Computer Engineering, Carleton University, Ottawa, ON, Canada. 4 Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada; Concordia University, Montreal, QC, Canada. 5 Department of Pathology, Yale University, 333 Cedar St., New Haven, CT 06511, USA. Electronic address: gianfilippo.coppola@yale.edu. 6 Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada; Department of Pathology, Yale University, 333 Cedar St., New Haven, CT |
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Description: |
Astroglial cells are key players in the development and maintenance of neurons and neuronal networks. Astroglia express steroid hormone receptors and show rapid responses to hormonal manipulations. However, despite important sex differences in the cortex and hippocampus, few studies have examined sex differences in astroglial cells in telencephalic development. To characterize the cortical astroglial translatome in male and female mice across postnatal development, we use translating ribosome affinity purification together with RNA sequencing and immunohistochemistry to phenotype astroglia at six developmental time points. Overall, we find two distinct astroglial phenotypes between early (P1-P7) and late development (P14-adult), independent of sex. We also find sex differences in gene expression patterns across development that peak at P7 and appear to result from males reaching a mature astroglial phenotype earlier than females. These developmental sex differences could have an impact on the construction of neuronal networks and windows of vulnerability to perturbations and disease. |
