Keyword search (4,164 papers available)

"focal cortical dysplasia" Keyword-tagged Publications:

Title Authors PubMed ID
1 Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia Heers M; Afnan J; Braun C; Grova C; Altenmüller DM; Steinhoff BJ; Dümpelmann M; Demerath T; Urbach H; Ethofer S; Siegel M; Schulze-Bonhage A; Lerche H; Li Hegner Y; 41804684
PERFORM
2 Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study. Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH 28510905
PERFORM
3 Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E 27578494
PERFORM

 

Title:Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.
Authors:DuBois JM,  Rousset OG,  Guiot MC,  Hall JA,  Reader AJ,  Soucy JP,  Rosa-Neto P,  Kobayashi E
Link:https://www.ncbi.nlm.nih.gov/pubmed/27578494?dopt=Abstract
DOI:10.1093/cercor/bhw249
Publication:Cerebral cortex (New York, N.Y. : 1991)
Keywords:[11C]ABP688;  epilepsy;  focal cortical dysplasia;  metabotropic glutamate receptor type 5;  positron-emission tomography; 
PMID:27578494 Category:Cereb Cortex Date Added:2019-04-15
Dept Affiliation: PERFORM
1 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4.
2 Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins University, Baltimore, MD 21287, USA.
3 Department of Pathology, McGill University, Montreal, Quebec, Canada H3A 2B4.
4 PET Unit, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.
5 Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London SE1 7EH, UK.
6 Bio-Imaging Group, PERFORM Centre, Concordia University, Montreal, Quebec, Canada H4B 1R6.
7 Translational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.

Description:

Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.

Cereb Cortex. 2016 10 17;26(11):4170-4179

Authors: DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Abstract

Metabotropic glutamate receptor type 5 (mGluR5) abnormalities have been described in tissue resected from epilepsy patients with focal cortical dysplasia (FCD). To determine if these abnormalities could be identified in vivo, we investigated mGluR5 availability in 10 patients with focal epilepsy and an MRI diagnosis of FCD using positron-emission tomography (PET) and the radioligand [11C]ABP688. Partial volume corrected [11C]ABP688 binding potentials (BPND) were computed using the cerebellum as a reference region. Each patient was compared to homotopic cortical regions in 33 healthy controls using region-of-interest (ROI) and vertex-wise analyses. Reduced [11C]ABP688 BPND in the FCD was seen in 7/10 patients with combined ROI and vertex-wise analyses. Reduced FCD BPND was found in 4/5 operated patients (mean follow-up: 63 months; Engel I), of whom surgical specimens revealed FCD type IIb or IIa, with most balloon cells showing negative or weak mGluR5 immunoreactivity as compared to their respective neuropil and normal neurons at the border of resections. [11C]ABP688 PET shows for the first time in vivo evidence of reduced mGluR5 availability in FCD, indicating focal glutamatergic alterations in malformations of cortical development, which cannot be otherwise clearly demonstrated through resected tissue analyses.

PMID: 27578494 [PubMed - indexed for MEDLINE]




BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University