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PubMed Publications| Keyword search (4,163 papers available) |  |
"epilepsy" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia | Heers M; Afnan J; Braun C; Grova C; Altenmüller DM; Steinhoff BJ; Dümpelmann M; Demerath T; Urbach H; Ethofer S; Siegel M; Schulze-Bonhage A; Lerche H; Li Hegner Y; | 41804684 PERFORM |
| 2 | SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis | Bögershausen N; Cavdarli B; Nagai T; Milev MP; Wolff A; Mehranfar M; Schmidt J; Choudhary D; Gutiérrez-Gutiérrez Ó; Cyganek L; Saint-Dic D; Zibat A; Köhrer K; Wollenweber TE; Wieczorek D; Altmüller J; Borodina T; Kaçar D; Haliloglu G; Li Y; Thiel C; Sacher M; Knapik EW; Yigit G; Wollnik B; | 40131364 BIOLOGY |
| 3 | Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology | Hrtonova V; Nejedly P; Travnicek V; Cimbalnik J; Matouskova B; Pail M; Peter-Derex L; Grova C; Gotman J; Halamek J; Jurak P; Brazdil M; Klimes P; Frauscher B; | 39608298 SOH |
| 4 | EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy | Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C; | 38994740 SOH |
| 5 | Systematic review of seizure-onset patterns in stereo-electroencephalography: Current state and future directions | Abdallah C; Mansilla D; Minato E; Grova C; Beniczky S; Frauscher B; | 38733701 PERFORM |
| 6 | How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism | Pellegrino G; Hedrich T; Sziklas V; Lina JM; Grova C; Kobayashi E; | 34002916 PERFORM |
| 7 | Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography. | Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B | 33450578 PERFORM |
| 8 | Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. | DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E | 33401137 PERFORM |
| 9 | Source imaging of deep-brain activity using the regional spatiotemporal Kalman filter | Hamid L; Habboush N; Stern P; Japaridze N; Aydin Ü; Wolters CH; Claussen JC; Heute U; Stephani U; Galka A; Siniatchkin M; | 33250282 PERFORM |
| 10 | Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients | Pellegrino G, Xu M, Alkuwaiti A, Porras-Bettancourt M, Abbas G, Lina JM, Grova C, Kobayashi E, | 32582009 PERFORM |
| 11 | Detection of abnormal resting-state networks in individual patients suffering from focal epilepsy: an initial step toward individual connectivity assessment. | Dansereau CL, Bellec P, Lee K, Pittau F, Gotman J, Grova C | 25565949 PERFORM |
| 12 | Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy. | Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E | 25609211 PERFORM |
| 13 | Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients. | von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E | 26830767 PERFORM |
| 14 | Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy. | Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E | 26931511 PERFORM |
| 15 | Source localization of the seizure onset zone from ictal EEG/MEG data. | Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C | 27059157 PERFORM |
| 16 | Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy. | Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C | 29164737 PERFORM |
| 17 | Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy. | Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C | 30094158 PERFORM |
| 18 | Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. | DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E | 27578494 PERFORM |
| Title: | Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia | ||||
| Authors: | Heers M, Afnan J, Braun C, Grova C, Altenmüller DM, Steinhoff BJ, Dümpelmann M, Demerath T, Urbach H, Ethofer S, Siegel M, Schulze-Bonhage A, Lerche H, Li Hegner Y | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41804684/ | ||||
| DOI: | 10.1002/epi.70191 | ||||
| Publication: | Epilepsia | ||||
| Keywords: | focal cortical dysplasia; focal epilepsy; magnetic source imaging; seizures; sleep; | ||||
| PMID: | 41804684 | Category: | Date Added: | 2026-03-10 | |
| Dept Affiliation: |
PERFORM
1 Epilepsy Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 2 Multimodal Functional Imaging Lab, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 3 Magnetoencephalography Center, University of Tübingen, Tübingen, Germany. 4 Department of Neural Dynamics and Magnetoencephalography, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. 5 Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany. 6 Centre De Recherches Mathématiques, Montreal, Quebec, Canada. 7 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Center, Concordia University, Montreal, Quebec, Canada. 8 Epilepsy Center Kork, Kehl-Kork, Germany. 9 Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg, Germany. 10 BrainLinks-BrainTools Center, University of Freiburg, Freiburg, Germany. 11 Department of Neuroradiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 12 Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany. 13 Center for Bionic Intelligence Tübingen Stuttgart, Tübingen, Germany. 14 German Center for Mental Health, Tübingen, Germany. 15 Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. |
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Description: |
Objective: Focal cortical dysplasia (FCD) causes drug-resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14-40 Hz) and gamma (40-80 Hz) frequency bands, and seizures. This study aimed to quantify sleep-associated changes in IEDs, FOs, and seizures in FCD patients using noninvasive magnetoencephalography (MEG). Methods: Nineteen patients with FCD were prospectively recruited and underwent simultaneous MEG/EEG recordings lasting 89 ± 19 min during daytime sleep. Sleep stages were classified from the EEG. Beamformer source signals were computed from the MEG signal to enhance sensitivity for visual detection of IEDs, FOs in the beta and gamma frequency bands, and seizures. Magnetic source imaging (MSI) was performed using the Maximum Entropy on the Mean (MEM) method, which is particularly sensitive to the spatial extent of sources, enabling accurate localization of epileptic activity. Results: N1 sleep was reached in 17 of 19 patients and N2 sleep in 14 of 19 patients. Compared to wakefulness, sleep recordings showed significantly higher rates of FOs and seizures (both p < .05), whereas IED rates showed nonsignificant trends. Ten patients demonstrated FOs or seizures, and 12 showed IEDs. MSI of IEDs demonstrated consistent accuracy across vigilance states, with median Euclidean distances of 12.74 mm (interquartile range [IQR] = 22.74) in wake and 8.34 mm (IQR = 27.58) in sleep, and no systematic amplitude or spatial extent changes. Wavelet-MEM enabled frequency-specific source imaging, with FOs and seizures localizing concordantly to FCD lesions in five of seven and seven of eight patients, respectively. Significance: Daytime sleep MEG recordings are clinically feasible and significantly enhance the detection of seizures (37% of patients) and FOs compared to wakefulness. Sleep protocols enable noninvasive capture of ictal patterns-the gold standard for epileptogenic zone localization-alongside increased FO rates. These findings support incorporating sleep into standard MEG protocols for presurgical epilepsy evaluation. |
