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PubMed Publications| Keyword search (4,163 papers available) |  |
"epigenetic inheritance" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction | Anne-Sophie Pepin | 35183795 PERFORM |
| 2 | Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring. | Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S | 33596408 PERFORM |
| Title: | Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction | ||||
| Authors: | Anne-Sophie Pepin | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35183795/ | ||||
| DOI: | 10.1016/j.molmet.2022.101463 | ||||
| Publication: | Molecular metabolism | ||||
| Keywords: | Chromatin; Epigenetic inheritance; Metabolism; Obesity; Sperm; | ||||
| PMID: | 35183795 | Category: | Date Added: | 2022-02-21 | |
| Dept Affiliation: |
PERFORM
1 Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada. 2 Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC H9X 3V9, Canada. 3 Department of Biology, PERFORM Center, Concordia University, Montreal, QC H4B 1R6, Canada. 4 Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC H9X 3V9, Canada. Electronic address: sarah.kimmins@mcgill.ca. |
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Description: |
CONCLUSIONS: Our data suggest sperm H3K4me3 might serve as a metabolic sensor that connects paternal diet with offspring phenotypes via the placenta. This non-DNA-based knowledge of inheritance has the potential to improve our understanding of how environment shapes heritability and may lead to novel routes for the prevention of disease. This study highlights the need to further study the connection between the sperm epigenome, placental development, and children's health. |
