Keyword search (4,163 papers available)

"drug delivery" Keyword-tagged Publications:

Title Authors PubMed ID
1 Editorial: Data-driven vaccine design for microbial-associated diseases Selvaraj G; Kaliamurthi S; Wei D; 41624882
CHEMBIOCHEM
2 Synthesis and Acidic pH-Responsive Disassembly of Dual-Location Shell-Sheddable/Core-Degradable Block Copolymer Nanoassemblies and Their Controlled Drug Delivery Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK; 41524627
CHEMBIOCHEM
3 Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization Andrade-Gagnon B; Casillas-Popova SN; Oh JK; 40614241
CHEMBIOCHEM
4 Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA He S; Singh D; Helfield B; 39850318
BIOLOGY
5 Shear stress preconditioning and microbubble flow pattern modulate ultrasound-assisted plasma membrane permeabilization Memari E; Helfield B; 38988819
BIOLOGY
6 17β-Estradiol-Loaded Exosomes for Targeted Drug Delivery in Osteoporosis: A Comparative Study of Two Loading Methods Gholami Farashah MS; Javadi M; Soleimani Rad J; Shakouri SK; Asnaashari S; Dastmalchi S; Nikzad S; Roshangar L; 38022800
BIOLOGY
7 Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux Memari E; Hui F; Yusefi H; Helfield B; 37150403
PHYSICS
8 Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide Choi M; Jazani AM; Oh JK; Noh SM; 35683912
CHEMBIOCHEM
9 Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing Huang HY; Skripka A; Zaroubi L; Findlay BL; Vetrone F; Skinner C; Oh JK; Cuccia LA; 35019380
CHEMBIOCHEM
10 Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK; 34050688
CHEMBIOCHEM
11 Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. Copp W, Pontarelli A, Wilds CJ 33506614
CHEMBIOCHEM
12 Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery. Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG 33455300
CHEMBIOCHEM
13 Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles. Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG 31820915
CHEMBIOCHEM
14 Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner. Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A 29080670
CSBN

 

Title:Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.
Authors:Huang Y,  Jazani AM,  Howell EP,  Reynolds LA,  Oh JK,  Moffitt MG
Link:https://www.ncbi.nlm.nih.gov/pubmed/33455300
DOI:10.1021/acsbiomaterials.0c00896
Publication:ACS biomaterials science & engineering
Keywords:directed self-assembly;  drug delivery;  microfluidics;  nanoparticles;  reduction-responsive block copolymers; 
PMID:33455300 Category:ACS Biomater Sci Eng Date Added:2021-01-20
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.
2 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.
3 Department of Biochemistry and Microbiology, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.

Description:

Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

ACS Biomater Sci Eng. 2020 Sep 14; 6(9):5069-5083

Authors: Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

Abstract

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of the physicochemical properties of GSH-responsive PNPs containing cleavable disulfide groups in two different locations (core and interface, DualM PNPs). In this paper, we employ a two-phase gas-liquid microfluidic reactor for the flow-directed manufacturing of paclitaxel-loaded or DiI-loaded DualM PNPs (PAX-PNPs or DiI-PNPs, where DiI is a fluorescent drug surrogate dye). We find that both PAX-PNPs and DiI-PNPs exhibit similar flow-tunable sizes, morphologies, and internal structures to those previously described for empty DualM PNPs. Fluorescent imaging of DiI-PNP formulations shows that microfluidic manufacturing greatly improves the homogeneity of drug dispersion within the PNP population compared to standard bulk microprecipitation. Encapsulation of PAX in DualM PNPs significantly increases its selectivity to cancerous cells, with various PAX-PNP formulations showing higher cytotoxicity against cancerous MCF-7 cells than against non-cancerous HaCaT cells, in contrast to free PAX, which showed similar cytotoxicity in the two cell lines. In addition, the characterization of DualM PNP formulations formed at various microfluidic flow rates reveals that critical figures of merit for drug delivery function-including encapsulation efficiencies, GSH-triggered release rates, rates of cell uptake, cytotoxicities, and selectivity to cancerous cells-exhibit microfluidic flow tunability that mirrors trends in PNP size. These results highlight the potential of two-phase microfluidic manufacturing for controlling both structure and drug delivery function of biological stimuli-responsive nanomedicines toward improved therapeutic outcomes.

PMID: 33455300 [PubMed - in process]




BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University