Keyword search (4,163 papers available)

"complex" Keyword-tagged Publications:

Title Authors PubMed ID
1 Pseudocapacitive MXene@Fe-TA ternary mediator enhances denitrification via optimized electron transfer and microbial regulation in wastewater treatment Pan S; Wang X; Guo T; An H; Guo Y; Chen Z; Lian J; Guo J; 41043789
ENCS
2 Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect" Sun B; Yang JG; Wang Z; Wang Z; Feng W; Li X; Liu SN; Li J; Zhu YQ; Zhang P; Wang W; 40051055
ENCS
3 Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; 39739397
SOH
4 AP-1 contributes to endosomal targeting of ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif Cabana VC; Sénécal AM; Bouchard AY; Kourrich S; Cappadocia L; Lussier MP; 39206621
CSBN
5 Microhabitat conditions drive uncertainty of risk and shape neophobic responses in Trinidadian guppies, Poecilia reticulata Feyten LEA; Ramnarine IW; Brown GE; 37753307
BIOLOGY
6 TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions Almousa H; Lewis SA; Bakhtiari S; Nordlie SH; Pagnozzi A; Magee H; Efthymiou S; Heim JA; Cornejo P; Zaki MS; Anwar N; Maqbool S; Rahman F; Neilson DE; Vemuri A; Jin SC; Yang XR; Heidari A; van Gassen K; Trimouille A; Thauvin-Robinet C; Liu J; Bruel AL; Tomoum H; Shata MO; Hashem MO; Toosi MB; Ghayoor Karimiani E; Yesil G; Lingappa L; Baruah D; Ebrahimzadeh F; Van-Gils J; Faivre L; Zamani M; Galehdari H; Sadeghian S; Shariati G; Mohammad R; van der Smagt J; Qari A; Vincent JB; Innes AM; Dursun A; Özgül RK; A 37713627
BIOLOGY
7 Cooperative Sensitization Upconversion in Solution Dispersions of Co-Crystal Assemblies of Mononuclear Yb3+ and Eu3+ Complexes Sun G; Xie Y; Wang Y; Mandl GA; Maurizio SL; Zhang H; Ottenwaelder X; Capobianco JA; Sun L; 37040148
CNSR
8 Invariant Pattern Recognition with Log-Polar Transform and Dual-Tree Complex Wavelet-Fourier Features Chen G; Krzyzak A; 37112182
ENCS
9 Rheological Assessment of Oil-Xanthan Emulsions in Terms of Complex, Storage, and Loss Moduli Ghannam MT; Selim MYE; Zekri AY; Esmail N; 36679350
ENCS
10 EEG complexity during mind wandering: A multiscale entropy investigation Cnudde K; Kim G; Murch WS; Handy TC; Protzner AB; Kam JWY; 36621593
CONCORDIA
11 Xylan glucuronic acid side chains fix suberin-like aliphatic compounds to wood cell walls Derba-Maceluch M; Mitra M; Hedenström M; Liu X; Gandla ML; Barbut FR; Abreu IN; Donev EN; Urbancsok J; Moritz T; Jönsson LJ; Tsang A; Powlowski J; Master ER; Mellerowicz EJ; 36600379
CSFG
12 Surfactant-enhanced mobilization of persistent organic pollutants: Potential for soil and sediment remediation and unintended consequences Bolan S; Padhye LP; Mulligan CN; Alonso ER; Saint-Fort R; Jasemizad T; Wang C; Zhang T; Rinklebe J; Wang H; Siddique KHM; Kirkham MB; Bolan N; 36265382
ENCS
13 A Review of Mathematical and Computational Methods in Cancer Dynamics Uthamacumaran A; Zenil H; 35957879
PHYSICS
14 Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics Abicumaran Uthamacumaran 35678918
PHYSICS
15 SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation Rashid S; Correia-Mesquita TO; Godoy P; Omran RP; Whiteway M; 35350439
BIOLOGY
16 Warm and arid regions of the world are hotspots of superorganism complexity La Richelière F; Muñoz G; Guénard B; Dunn RR; Economo EP; Powell S; Sanders NJ; Weiser MD; Abouheif E; Lessard JP; 35135345
BIOLOGY
17 Cancer: A turbulence problem. Uthamacumaran A 33142240
CONCORDIA
18 The sensation of groove engages motor and reward networks. Matthews TE, Witek MAG, Lund T, Vuust P, Penhune VB 32217163
PSYCHOLOGY
19 TRAPPing a neurological disorder: from yeast to humans. Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N 32116085
BIOLOGY
20 Polymorphism of MHC class IIB in an acheilognathid species, Rhodeus sinensis shaped by historical selection and recombination. Jeon HB, Won H, Suk HY 31519169
BIOLOGY
21 The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans. Tebbji F, Chen Y, Sellam A, Whiteway M 29152582
BIOLOGY
22 Ideal despotic distributions in convict cichlids (Amatitlania nigrofasciata)? Effects of predation risk and personality on habitat preference. Church KDW, Grant JWA 30529688
BIOLOGY
23 Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast. Pinel D, Colatriano D, Jiang H, Lee H, Martin VJ 25866561
CSFG
24 Saccharification efficiencies of multi-enzyme complexes produced by aerobic fungi. Badhan A, Huang J, Wang Y, Abbott DW, Di Falco M, Tsang A, McAllister T 29803771
CSFG
25 Impaired sensorimotor processing during complex gait precedes behavioral changes in middle-aged adults. Mitchell T, Starrs F, Soucy JP, Thiel A, Paquette C 30247510
PERFORM

 

Title:Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast.
Authors:Pinel DColatriano DJiang HLee HMartin VJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/25866561?dopt=Abstract
DOI:10.1186/s13068-015-0241-z
Publication:Biotechnology for biofuels
Keywords:Complex traitEvolutionary engineeringGenome shufflingReverse engineeringToleranceYeast
PMID:25866561 Category:Biotechnol Biofuels Date Added:2019-06-07
Dept Affiliation: CSFG
1 Department of Biology, Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6 Canada ; Current address: Energy Biosciences Institute, University of California, Berkeley, Berkeley, CA 94704 USA.
2 Department of Biology, Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6 Canada.
3 Department of Biology, Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6 Canada ; Current address: Crabtree Nutrition Laboratories, McGill University Health Center, Montreal, Quebec H3A 1A1 Canada.
4 School of Environmental Sciences, University of Guelph, Guelph, Ontario N1G 2 W1 Canada.

Description:

Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast.

Biotechnol Biofuels. 2015;8:53

Authors: Pinel D, Colatriano D, Jiang H, Lee H, Martin VJ

Abstract

BACKGROUND: Identifying the genetic basis of complex microbial phenotypes is currently a major barrier to our understanding of multigenic traits and our ability to rationally design biocatalysts with highly specific attributes for the biotechnology industry. Here, we demonstrate that strain evolution by meiotic recombination-based genome shuffling coupled with deep sequencing can be used to deconstruct complex phenotypes and explore the nature of multigenic traits, while providing concrete targets for strain development.

RESULTS: We determined genomic variations found within Saccharomyces cerevisiae previously evolved in our laboratory by genome shuffling for tolerance to spent sulphite liquor. The representation of these variations was backtracked through parental mutant pools and cross-referenced with RNA-seq gene expression analysis to elucidate the importance of single mutations and key biological processes that play a role in our trait of interest. Our findings pinpoint novel genes and biological determinants of lignocellulosic hydrolysate inhibitor tolerance in yeast. These include the following: protein homeostasis constituents, including Ubp7p and Art5p, related to ubiquitin-mediated proteolysis; stress response transcriptional repressor, Nrg1p; and NADPH-dependent glutamate dehydrogenase, Gdh1p. Reverse engineering a prominent mutation in ubiquitin-specific protease gene UBP7 in a laboratory S. cerevisiae strain effectively increased spent sulphite liquor tolerance.

CONCLUSIONS: This study advances understanding of yeast tolerance mechanisms to inhibitory substrates and biocatalyst design for a biomass-to-biofuel/biochemical industry, while providing insights into the process of mutation accumulation that occurs during genome shuffling.

PMID: 25866561 [PubMed]





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