PERFORM Publications

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Title		Authors	PubMed ID
1	Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast	Leonov A; Feldman R; Piano A; Arlia-Ciommo A; Junio JAB; Orfanos E; Tafakori T; Lutchman V; Mohammad K; Elsaser S; Orfali S; Rajen H; Titorenko VI;	35937500 BIOLOGY
2	Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast	Mohammad K; Orfanos E; Titorenko VI;	34853658 BIOLOGY
3	Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors	Mohammad K; Titorenko VI;	33868583 BIOLOGY
4	Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.	Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI	32630624 BIOLOGY
5	Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast.	Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É, Titorenko VI	32577164 BIOLOGY
6	Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.	Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI	31645900 BIOLOGY
7	Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.	Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI	25839782 MASSSPEC
8	Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.	Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI	29050207 BIOLOGY
9	Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.	Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI	29662634 BIOLOGY
10	Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.	Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI	30405886 BIOLOGY
11	Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.	Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI	30719227 BIOLOGY

Title:	Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.
Authors:	Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32630624?dopt=Abstract
DOI:	10.3390/ijms21134717
Publication:	International journal of molecular sciences
Keywords:	caloric restriction; cell cycle; cellular aging; cellular quiescence; metabolism; properties of quiescent yeast; quiescence entry; quiescence maintenance; yeast; yeast chronological aging;
PMID:	32630624	Category:	Int J Mol Sci	Date Added:	2020-07-08
Dept Affiliation:	BIOLOGY 1 Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.

Int J Mol Sci. 2020 Jul 02;21(13):

Authors: Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Abstract

After Saccharomyces cerevisiae cells cultured in a medium with glucose consume glucose, the sub-populations of quiescent and non-quiescent cells develop in the budding yeast culture. An age-related chronology of quiescent and non-quiescent yeast cells within this culture is discussed here. We also describe various hallmarks of quiescent and non-quiescent yeast cells. A complex aging-associated program underlies cellular quiescence in budding yeast. This quiescence program includes a cascade of consecutive cellular events orchestrated by an intricate signaling network. We examine here how caloric restriction, a low-calorie diet that extends lifespan and healthspan in yeast and other eukaryotes, influences the cellular quiescence program in S. cerevisiae. One of the main objectives of this review is to stimulate an exploration of the mechanisms that link cellular quiescence to chronological aging of budding yeast. Yeast chronological aging is defined by the length of time during which a yeast cell remains viable after its growth and division are arrested, and it becomes quiescent. We propose a hypothesis on how caloric restriction can slow chronological aging of S. cerevisiae by altering the chronology and properties of quiescent cells. Our hypothesis posits that caloric restriction delays yeast chronological aging by targeting four different processes within quiescent cells.

PMID: 32630624 [PubMed - in process]

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