Keyword search (4,163 papers available)

"candida albicans" Keyword-tagged Publications:

Title Authors PubMed ID
1 Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y; 38995235
BIOLOGY
2 Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y; 38929106
BIOLOGY
3 Antimicrobial photodynamic therapy against a dual-species cariogenic biofilm using a ruthenium-loaded resin-based dental material Leite ML; Comeau P; Aghakeshmiri S; Lange D; Rodrigues LKA; Branda N; Manso AP; 38395246
ENCS
4 A Systematic Evaluation of Curcumin Concentrations and Blue Light Parameters towards Antimicrobial Photodynamic Therapy against Cariogenic Microorganisms Comeau P; Manso A; 38140048
ENCS
5 Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections Feng Y; Lu H; Whiteway M; Jiang Y; 37918789
BIOLOGY
6 Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT; 37888959
BIOLOGY
7 The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M; 37791798
BIOLOGY
8 A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y; 36475771
BIOLOGY
9 A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT; 35972285
BIOLOGY
10 Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J; 35886903
BIOLOGY
11 Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions Godoy P; Darlington PJ; Whiteway M; 35450285
PERFORM
12 SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation Rashid S; Correia-Mesquita TO; Godoy P; Omran RP; Whiteway M; 35350439
BIOLOGY
13 The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans Omran RP; Ramírez-Zavala B; Aji Tebung W; Yao S; Feng J; Law C; Dumeaux V; Morschhäuser J; Whiteway M; 34849863
PERFORM
14 Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target Li W; Shrivastava M; Lu H; Jiang Y; 33989979
BIOLOGY
15 Signal-mediated localization of Candida albicans pheromone response pathway components Costa ACBP; Omran RP; Law C; Dumeaux V; Whiteway M; 33793759
PERFORM
16 Candida albicans targets that potentially synergize with fluconazole. Lu H, Shrivastava M, Whiteway M, Jiang Y 33587857
BIOLOGY
17 Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans. Yao S, Feng Y, Islam A, Shrivastava M, Gu H, Lu Y, Sheng J, Whiteway M, Feng J 33363697
BIOLOGY
18 Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans. Feng J, Yao S, Dong Y, Hu J, Whiteway M, Feng J 32075883
BIOLOGY
19 RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans. Xu H, Fang T, Omran RP, Whiteway M, Jiang L 31900175
BIOLOGY
20 The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans. Tebbji F, Chen Y, Sellam A, Whiteway M 29152582
BIOLOGY
21 Chemogenomic Profiling of the Fungal Pathogen Candida albicans. Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M 29203491
BIOLOGY
22 MAP Kinase Regulation of the Candida albicans Pheromone Pathway. Rastghalam G, Omran RP, Alizadeh M, Fulton D, Mallick J, Whiteway M 30787119
BIOLOGY
23 The evolutionary rewiring of the ribosomal protein transcription pathway modifies the interaction of transcription factor heteromer Ifh1-Fhl1 (interacts with forkhead 1-forkhead-like 1) with the DNA-binding specificity element. Mallick J, Whiteway M 23625919
BIOLOGY
24 Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response. Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M 30530734
PERFORM

 

Title:Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections
Authors:Feng YLu HWhiteway MJiang Y
Link:https://pubmed.ncbi.nlm.nih.gov/37918789/
DOI:10.1016/j.jgar.2023.10.019
Publication:Journal of global antimicrobial resistance
Keywords:Candida albicansFluconazole synergistic lethal adjuvantsFluconazole synergistic lethal targetsFluconazole toleranceInvasive fungal disease
PMID:37918789 Category: Date Added:2023-11-03
Dept Affiliation: BIOLOGY
1 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
2 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: luhui2019@tongji.edu.cn.
3 Department of Biology, Concordia University, Montreal, QC, Canada. Electronic address: malcolm.whiteway@concordia.ca.
4 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: 19851@tongji.edu.cn.

Description:

Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully explored. This review discusses the high incidence of FLC tolerance in Candida species and the importance of successfully clearing FLC tolerance in treating candidiasis. We further define and characterize FLC tolerance in C. albicans and suggest that FLC tolerance is a strategy of C. albicans response to FLC damage whose mechanism differs from FLC resistance. This review identifies global factors affecting FLC tolerance and highlights the significance of the cell membrane and cell wall integrity in FLC tolerance, guiding approaches to combat IFDs caused by Candida species.





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