Keyword search (4,163 papers available)

"basolateral amygdala" Keyword-tagged Publications:

Title Authors PubMed ID
1 What is Learned Determines How Pavlovian Conditioned Fear is Consolidated in the Brain Leake J; Leidl DM; Lay BPP; Fam JP; Giles MC; Qureshi OA; Westbrook RF; Holmes NM; 37963767
CSBN
2 NMDA Receptors in the Basolateral Amygdala Complex Are Engaged for Pavlovian Fear Conditioning When an Animal's Predictions about Danger Are in Error Tuval Keidar 37607821
CSBN
3 Danger Changes the Way the Brain Consolidates Neutral Information; and Does So by Interacting with Processes Involved in the Encoding of That Information Omar A Qureshi 36927572
PSYCHOLOGY
4 Prediction error determines whether NMDA receptors in the basolateral amygdala complex are involved in Pavlovian fear conditioning Williams-Spooner MJ; Delaney AJ; Westbrook RF; Holmes NM; 35410880
PSYCHOLOGY
5 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN

 

Title:Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.
Authors:Lafferty CK,  Yang AK,  Mendoza JA,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/32187545?dopt=Abstract
DOI:10.1016/j.celrep.2020.02.095
Publication:Cell reports
Keywords:basolateral amygdala;  behavioral inhibition;  direct pathway;  fiber photometry;  indirect pathway;  nucleus accumbens;  optogenetics;  paraventricular nucleus of the thalamus;  place preference;  self-stimulation; 
PMID:32187545 Category:Cell Rep Date Added:2020-03-19
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
3 Department of Psychology, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3

Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Abstract

The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when reward is and is not available. Although direct pathway stimulation is rewarding and indirect pathway stimulation aversive, the activity of both cell types is elevated during periods of behavioral suppression, and the inhibition of either cell-type selectively increases unproductive reward seeking. Amygdala and thalamic inputs are also necessary for behavioral suppression, even though they both support self-stimulation and innervate different NAc subregions. These data suggest that efficient reward seeking relies on complementary activity across NAc cell types and inputs rather than opponent processes between them.

PMID: 32187545 [PubMed - as supplied by publisher]




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