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PubMed Publications| Keyword search (4,163 papers available) |  |
"antimicrobial resistance" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Discovery of an adjuvant that resensitizes polymyxin B-resistant bacteria | Mahdavi M; Findlay BL; | 38096681 BIOLOGY |
| 2 | Phase Diagram for a Lysyl-Phosphatidylglycerol Analogue in Biomimetic Mixed Monolayers with Phosphatidylglycerol: Insights into the Tunable Properties of Bacterial Membranes. | Wölk C, Youssef H, Guttenberg T, Marbach H, Vizcay-Barrena G, Shen C, Brezesinski G, Harvey RD | 32065707 CHEMBIOCHEM |
| 3 | Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy. | Kraemer SA, Ramachandran A, Perron GG | 31234491 BIOLOGY |
| Title: | Discovery of an adjuvant that resensitizes polymyxin B-resistant bacteria | ||||
| Authors: | Mahdavi M, Findlay BL | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38096681/ | ||||
| DOI: | 10.1016/j.bmc.2023.117541 | ||||
| Publication: | Bioorganic & medicinal chemistry | ||||
| Keywords: | Adjuvants; Antibiotics; Antimicrobial resistance; Membrane permeabilizers; Perforone; | ||||
| PMID: | 38096681 | Category: | Date Added: | 2023-12-15 | |
| Dept Affiliation: |
BIOLOGY
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada. 2 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada; Department of Biology, Concordia University, Montréal, Québec, Canada. Electronic address: brandon.findlay@concordia.ca. |
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Description: |
Infections caused by antibiotic-resistant bacteria are a major threat to health, increasing mortality rates and straining health systems worldwide. Adjuvants targeted to beta-lactamase function are able to resensitize bacteria to beta-lactam antibiotics, but there is comparatively little research into the use of adjuvants against other resistance phenotypes. In this study, we performed a high-throughput screen of 74 natural products to identify adjuvants that synergized with antibiotics to eradicate resistant Gram-negative bacteria. From this, we identified six adjuvant hits which restored growth inhibition when combined with the relevant antibiotic, and pursued a lead candidate, perforone, which possessed selective adjuvant activity in combination with polymyxin B against polymyxin-resistant Escherichia coli cells. These results suggest that pairing adjuvants with antibiotics could be a useful general intervention against resistant bacteria, helping to mitigate the effects of antimicrobial resistance. |
