Keyword search (4,163 papers available)

"Self-assembly" Keyword-tagged Publications:

Title Authors PubMed ID
1 Research Trends in the Development of Block Copolymer-Based Biosensing Platforms Chung YH; Oh JK; 39590001
CHEMBIOCHEM
2 Dual acting acid-cleavable self-assembling prodrug from hyaluronic acid and ciprofloxacin: A potential system for simultaneously targeting bacterial infections and cancer Ibrahim UH; Devnarain N; Mohammed M; Omolo CA; Gafar MA; Salih M; Pant A; Shunmugam L; Mocktar C; Khan R; Oh JK; Govender T; 36150574
CHEMBIOCHEM
3 Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery. Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG 33455300
CHEMBIOCHEM
4 Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles. Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG 31820915
CHEMBIOCHEM
5 O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron. Copp W, Wilds CJ 32543755
CHEMBIOCHEM

 

Title:O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron.
Authors:Copp WWilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/32543755?dopt=Abstract
DOI:10.1002/chem.202002565
Publication:Chemistry (Weinheim an der Bergstrasse, Germany)
Keywords:DNA nanotechnologyDNA tetrahedronDNA-protein interactionshAGTself-assembly
PMID:32543755 Category:Chemistry Date Added:2020-06-17
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, H4B 1R6, Canada.

Description:

O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron.

Chemistry. 2020 Jun 16;:

Authors: Copp W, Wilds CJ

Abstract

Tetrahedron DNA structures were formed by the assembly of three-way junction (TWJ) oligonucleotides containing O6-2'-deoxyguanosine-alkylene-O6-2'-deoxyguanosine (butylene and heptylene linked) intrastrand cross-links (IaCLs) lacking a phosphodiester group between the 2'-deoxyribose residues. The DNA tetrahedra containing TWJs were shown to undergo an unhooking reaction by the human DNA repair protein O6-alkylguanine DNA alkyltransferase (hAGT) resulting in structure disassembly. The unhooking reaction of hAGT towards the DNA tetrahedra was observed to be moderate to virtually complete depending on the protein equivalents. DNA tetrahedron structures have been explored as drug delivery platforms that release their payload in response to triggers such as light, chemical agents or hybridization of release strands. The dismantling of DNA tetrahedron structures by a DNA repair protein contributes to the armamentarium of approaches for drug release employing DNA nanostructures.

PMID: 32543755 [PubMed - as supplied by publisher]





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