Keyword search (4,163 papers available)

"Rab" Keyword-tagged Publications:

Title Authors PubMed ID
1 Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults Brooks M; El Chami R; Jourde HR; Savard MA; Coffey EBJ; 41878310
PSYCHOLOGY
2 Obsessive-compulsive symptoms moderate the effect of contamination motion on disgust intensity Pelzer M; Ouellet-Courtois C; Krause S; Coughtrey A; Fink-Lamotte J; 40858003
CCRH
3 Wearable biosensors: A comprehensive overview Wu KY; Su ME; Kim Y; Nguyen L; Marchand M; Tran SD; 40683741
ENCS
4 Cultural Adaptation and Validation of the Athlete Fear-Avoidance Questionnaire in Arabic: Preliminary Analysis of Fear-Avoidance in ACL-Reconstructed Recreational Players Alanazi R; Kashoo FZ; Alrashdi N; Alanazi S; Shaik AR; Sirajudeen MS; Alenazi A; Nambi G; Dover G; Alanazi AD; 40190690
HKAP
5 A person-centered examination of adverse childhood experiences and associated distal health, mental health, and behavioral outcomes in the United Arab Emirates Murphy A; Elbarazi I; Horen N; Ismail-Allouche Z; Long T; McNeill A; Arafat C; England D; 40001056
PSYCHOLOGY
6 In Shift and In Variance: Assessing the Robustness of HAR Deep Learning Models Against Variability Khaked AA; Oishi N; Roggen D; Lago P; 39860799
ENCS
7 The long shadow of accumulating adverse childhood experiences on mental health in the United Arab Emirates: implications for policy and practice Murphy A; England D; Elbarazi I; Horen N; Long T; Ismail-Allouche Z; Arafat C; 39100953
PSYCHOLOGY
8 Evaluation of human vulnerability and toxic effects of chronic and acute occupational exposure to ammonia: A case study in an ice factory Soltanzadeh A; Mahdinia M; Nikbakht N; Hosseinzadeh K; Sadeghi-Yarandi M; 38143407
ENCS
9 Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights Joshua Stokar 37571418
HKAP
10 Oligonucleotides Containing C5-Propynyl Modified Arabinonucleic Acids: Synthesis, Biophysical and Antisense Properties Pontarelli A; Wilds CJ; 36857293
CHEMBIOCHEM
11 Outdoor heat stress assessment using an integrated multi-scale numerical weather prediction system: A case study of a heatwave in Montreal Katal A; Leroyer S; Zou J; Nikiema O; Albettar M; Belair S; Wang L; 36587678
ENCS
12 We're building it up to burn it down: fire occurrence and fire-related climatic patterns in Brazilian biomes Diele Viegas LM; Sales L; Hipólito J; Amorim C; Johnson de Pereira E; Ferreira P; Folta C; Ferrante L; Fearnside P; Mendes Malhado AC; Frederico Duarte Rocha C; M Vale M; 36312759
BIOLOGY
13 Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H Pontarelli A; Wilds CJ; 35452799
CHEMBIOCHEM
14 An analysis of security vulnerabilities in container images for scientific data analysis Kaur B; Dugré M; Hanna A; Glatard T; 34080631
ENCS
15 On the Impact of Biceps Muscle Fatigue in Human Activity Recognition. Elshafei M, Costa DE, Shihab E 33557239
ENCS
16 Towards Detecting Biceps Muscle Fatigue in Gym Activity Using Wearables. Elshafei M, Shihab E 33498702
ENCS
17 PASS: A Multimodal Database of Physical Activity and Stress for Mobile Passive Body/ Brain-Computer Interface Research Parent M; Albuquerque I; Tiwari A; Cassani R; Gagnon JF; Lafond D; Tremblay S; Falk TH; 33363449
PERFORM
18 WAUC: A Multi-Modal Database for Mental Workload Assessment Under Physical Activity Albuquerque I; Tiwari A; Parent M; Cassani R; Gagnon JF; Lafond D; Tremblay S; Falk TH; 33335465
PERFORM
19 Contactless Capacitive Electrocardiography Using Hybrid Flexible Printed Electrodes. Lessard-Tremblay M, Weeks J, Morelli L, Cowan G, Gagnon G, Zednik RJ 32927651
ENCS
20 Chronic Neuroleptic-Induced Parkinsonism Examined with Positron Emission Tomography. Galoppin M, Berroir P, Soucy JP, Suzuki Y, Lavigne GJ, Gagnon JF, Montplaisir JY, Stip E, Blanchet PJ 32353194
PERFORM
21 TRAPPing a neurological disorder: from yeast to humans. Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N 32116085
BIOLOGY
22 Body image-related cognitive fusion and disordered eating: the role of self-compassion and sad mood. Scardera S, Sacco S, Di Sante J, Booij L 32086789
PSYCHOLOGY
23 Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay. Karim MA, Samyn DR, Mattie S, Brett CL 29135058
BIOLOGY
24 Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts. Milev MP, Graziano C, Karall D, Kuper WFE, Al-Deri N, Cordelli DM, Haack TB, Danhauser K, Iuso A, Palombo F, Pippucci T, Prokisch H, Saint-Dic D, Seri M, Stanga D, Cenacchi G, van Gassen KLI, Zschocke J, Fauth C, Mayr JA, Sacher M, van Hasselt PM 30120216
BIOLOGY
25 TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins. Sacher M, Shahrzad N, Kamel H, Milev MP 30152084
BIOLOGY
26 Rab-Effector-Kinase Interplay Modulates Intralumenal Fragment Formation during Vacuole Fusion. Karim MA, McNally EK, Samyn DR, Mattie S, Brett CL 30269949
BIOLOGY
27 Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl substrates. Jones DR, Uddin MS, Gruninger RJ, Pham TTM, Thomas D, Boraston AB, Briggs J, Pluvinage B, McAllister TA, Forster RJ, Tsang A, Selinger LB, Abbott DW 28588026
CSFG

 

Title:Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H
Authors:Pontarelli AWilds CJ
Link:https://pubmed.ncbi.nlm.nih.gov/35452799/
DOI:10.1016/j.bmcl.2022.128744
Publication:Bioorganic & medicinal chemistry letters
Keywords:Arabino nucleic acidsC5-propynyl nucleosidesE coli RNase HModified oligonucleotidesNuclease stability
PMID:35452799 Category: Date Added:2022-04-23
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141 Rue Sherbrooke Ouest, Montréal, Québec, H4B 1R6, Canada.
2 Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141 Rue Sherbrooke Ouest, Montréal, Québec, H4B 1R6, Canada. Electronic address: Chris.Wilds@concordia.ca.

Description:

The promise of the antisense approach to treat a variety of diseases with oligonucleotides and solutions to challenges that have been encountered in their development is attributable to chemical modification of the nucleic acid scaffold. Herein, we describe preliminary data regarding the synthesis of a novel C5-propynyl-ß-D-arabinouridine (araUP) phosphoramidite and its incorporation into oligonucleotides. Substitution of araUP in dT18 results in minor stabilization of duplexes formed with RNA when modifications are placed consecutively and a uniformly modified araUP 18-mer increases stability by 34 °C relative to DNA. The modified oligomer exhibits improved nuclease and serum stability when compared to DNA and duplexes formed between RNA and araUP oligonucleotides are substrates for E. coli RNase H. These preliminary results merit further investigation into C5-propynyl modified arabino nucleic acids for potential therapeutic gene silencing applications.





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