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PubMed Publications| Keyword search (4,163 papers available) |  |
"Proteomics" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Comparative proteomic analysis of self-compatible and self-incompatible genotypes of fennel (Foeniculum vulgare Mill.) | Mirzahosseini Z; Shabani L; Sabzalian MR; Shojaiefar S; Dayanandan S; | 40691524 BIOLOGY |
| 2 | New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice | Golizeh M; Nam J; Chatelain E; Jackson Y; Ohlund LB; Rasoolizadeh A; Camargo FV; Mahrouche L; Furtos A; Sleno L; Ndao M; | 36590505 CHEMBIOCHEM |
| 3 | Evidence for ligninolytic activity of the ascomycete fungus Podospora anserina. | van Erven G, Kleijn AF, Patyshakuliyeva A, Di Falco M, Tsang A, de Vries RP, van Berkel WJH, Kabel MA | 32322305 CSFG |
| 4 | Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment | Malkawi AK; Masood A; Shinwari Z; Jacob M; Benabdelkamel H; Matic G; Almuhanna F; Dasouki M; Alaiya AA; Rahman AMA; | 31247941 CHEMBIOCHEM |
| 5 | Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing. | Saito MA, Bertrand EM, Duffy ME, Gaylord DA, Held NA, Hervey WJ, Hettich RL, Jagtap PD, Janech MG, Kinkade DB, Leary DH, McIlvin MR, Moore EK, Morris RM, Neely BA, Nunn BL, Saunders JK, Shepherd AI, Symmonds NI, Walsh DA | 30702898 BIOLOGY |
| 6 | Isolation and Preparation of Extracellular Proteins from Lignocellulose Degrading Fungi for Comparative Proteomic Studies Using Mass Spectrometry | Robert J Gruninger | 28417377 CSFG |
| 7 | Introduction: Overview of Fungal Genomics. | de Vries RP, Grigoriev IV, Tsang A | 29876804 CSFG |
| Title: | New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice | ||||
| Authors: | Golizeh M, Nam J, Chatelain E, Jackson Y, Ohlund LB, Rasoolizadeh A, Camargo FV, Mahrouche L, Furtos A, Sleno L, Ndao M | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/36590505/ | ||||
| DOI: | 10.1016/j.heliyon.2022.e12380 | ||||
| Publication: | Heliyon | ||||
| Keywords: | Biomarker discovery; Chagas disease; Glutamine; Mass spectrometry; Metabolomics; Mouse model; Phenylalanyl-threonine; Proteomics; Pyroglutamyl-glycine; Sex steroids; Taurine; Testis; Testosterone; Trypanosoma cruzi; | ||||
| PMID: | 36590505 | Category: | Date Added: | 2023-01-02 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Edmonton, Alberta, Canada. 2 National Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada. 3 Infectious Diseases and Immunity in Global Health (IDIGH) Program, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada. 4 Drugs for Neglected Diseases initiative, Geneva, Switzerland. 5 Division of Primary Care Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 6 Chemistry Department, Université du Québec à Montréal, Montreal, Quebec, Canada. 7 Center for Excellence in Research on Orphan Diseases - Fondation Courtois (CERMO-FC), Montreal, Quebec, Canada. 8 Chemistry Department, Regional Centre for Mass Spectrometry, Université de Montréal, Montreal, Quebec, Canada. 9 Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada. 10 Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada. |
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Description: |
The causative agent of Chagas disease (CD), Trypanosoma cruzi, claims thousands of lives each year. Current diagnostic tools are insufficient to ensure parasitological detection in chronically infected patients has been achieved. A host-derived metabolic signature able to distinguish CD patients from uninfected individuals and assess antiparasitic treatment efficiency is introduced. Serum samples were collected from chronic CD patients, prior to and three years after treatment, and subjected to untargeted metabolomics analysis against demographically matched CD-negative controls. Five metabolites were confirmed by high-resolution tandem mass spectrometry. Several database matches for sex steroids were significantly altered in CD patients. A murine experiment corroborated sex steroid perturbation in T. cruzi-infected mice, particularly in male animals. Proteomics analysis also found increased steroidogenesis in the testes of infected mice. Metabolic alterations identified in this study shed light on the pathogenesis and provide the basis for developing novel assays for the diagnosis and screening of CD patients. |
