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PubMed Publications| Keyword search (4,163 papers available) |  |
"Progestin" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology | Lacasse JM; Gomez-Perales E; Brake WG; | 35952797 PSYCHOLOGY |
| Title: | Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology | ||||
| Authors: | Lacasse JM, Gomez-Perales E, Brake WG | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35952797/ | ||||
| DOI: | 10.1016/j.yfrne.2022.101020 | ||||
| Publication: | Frontiers in neuroendocrinology | ||||
| Keywords: | Animal models; Dose; Ethinyl estradiol; Female rats; Hormonal contraceptives; Levonorgestrel; Methodology; Progestin; | ||||
| PMID: | 35952797 | Category: | Date Added: | 2022-08-12 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Canada, H4B 1R6. Electronic address: lacasse.jesse@gmail.com. 2 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Canada, H4B 1R6. 3 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Canada, H4B 1R6. Electronic address: wayne.brake@concordia.ca. |
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Description: |
Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations regarding dosing, route of administration, exposure time/timing, and selecting a control group. We also provide a framework outlining important levels of analysis for thinking about the impact of HC on behavioral and neurobiological outcomes. The purpose of this review is to equip researchers with foundational knowledge, and some basic elements of experimental design for future studies investigating the impact of HC on the brain and behavior of female rats. |
