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PubMed Publications| Keyword search (4,163 papers available) |  |
"PET imaging" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [(18)F]-FEOBV | Legault-Denis C; Aghourian M; Soucy JP; Rosa-Neto P; Dagher A; Aumont E; Wickens R; Bedard MA; | 34628195 PERFORM |
| 2 | Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18F-FEOBV. | Bedard MA, Aghourian M, Legault-Denis C, Postuma RB, Soucy JP, Gagnon JF, Pelletier A, Montplaisir J | 31078078 PERFORM |
| Title: | Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [(18)F]-FEOBV | ||||
| Authors: | Legault-Denis C, Aghourian M, Soucy JP, Rosa-Neto P, Dagher A, Aumont E, Wickens R, Bedard MA | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34628195/ | ||||
| DOI: | 10.1016/j.parkreldis.2021.09.018 | ||||
| Publication: | Parkinsonism & related disorders | ||||
| Keywords: | Acetylcholine; Cognition; FEOBV; Mild cognitive impairment; PET imaging; | ||||
| PMID: | 34628195 | Category: | Date Added: | 2021-10-12 | |
| Dept Affiliation: |
PERFORM
1 NeuroQAM Research Centre, Université du Québec à Montréal (UQAM), Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada. 2 McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada; PERFORM Research Centre, Concordia University, Canada. 3 McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada; McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Canada. 4 McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada. 5 NeuroQAM Research Centre, Université du Québec à Montréal (UQAM), Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada; McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Canada. Electronic address: bedard.marc-andre@uqam.ca. |
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Description: |
Background: Severe cholinergic degeneration is known to occur in Parkinson's disease (PD) and is thought to play a primary role in the cognitive decline associated with this disease. Although cholinergic losses occur in all patients with PD, cognitive performance remains normal for many of them, suggesting compensatory mechanisms in those. Objectives: This exploratory study aimed at verifying if normal cognition in PD may involve distinctive features of the brain cholinergic systems. Methods: Following extensive neuropsychological screening in 25 patients with PD, 12 were selected and evenly distributed between a cognitively normal (PD-CN) group, and a mild cognitive impairment (PD-MCI) group. Each group was compared with matched healthy volunteers (HV) on standardized cognitive scales (MoCA, PDCRS), and PET imaging with [18F]-FEOBV, a sensitive measurement of brain cholinergic innervation density. Results: [18F]-FEOBV uptake reductions were observed in PD-CN as well as in PD-MCI, with the lowest values located in the posterior cortical areas. However, in PD-CN but not in PD-MCI, there was a significant and bilateral increase of [18F]-FEOBV uptake, exclusively located in the hippocampus. Significant correlations were observed between cognitive performance and hippocampal [18F]-FEOBV uptake. Conclusion: These findings suggest a compensatory upregulation of the hippocampal cholinergic innervation in PD-CN, which might underly normal cognitive performances in spite of cortical cholinergic denervation in other regions. |
