Keyword search (4,163 papers available)

"Microfluidics" Keyword-tagged Publications:

Title Authors PubMed ID
1 Microfluidic Liquid Biopsy Minimally Invasive Cancer Diagnosis by Nano-Plasmonic Label-Free Detection of Extracellular Vesicles: Review Neriya Hegade KP; Bhat RB; Packirisamy M; 40650129
ENCS
2 An Automated Single-Cell Droplet-Digital Microfluidic Platform for Monoclonal Antibody Discovery Ahmadi F; Tran H; Letourneau N; Little SR; Fortin A; Moraitis AN; Shih SCC; 38441226
BIOLOGY
3 Measuring prion propagation in single bacteria elucidates a mechanism of loss Jager K; Orozco-Hidalgo MT; Springstein BL; Joly-Smith E; Papazotos F; McDonough E; Fleming E; McCallum G; Yuan AH; Hilfinger A; Hochschild A; Potvin-Trottier L; 37738299
PHYSICS
4 An electrochemical aptasensor for Δ9-tetrahydrocannabinol detection in saliva on a microfluidic platform Kékedy-Nagy L; Perry JM; Little SR; Llorens OY; Shih SCC; 36549107
BIOLOGY
5 Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications Allard P; Papazotos F; Potvin-Trottier L; 36312536
BIOLOGY
6 Microfluidics in smart packaging of foods Pou KRJ; Raghavan V; Packirisamy M; 36192908
ENCS
7 Microfluidic Platforms for the Isolation and Detection of Exosomes: A Brief Review Raju D; Bathini S; Badilescu S; Ghosh A; Packirisamy M; 35630197
ENCS
8 Numerical and Experimental Validation of Mixing Efficiency in Periodic Disturbance Mixers López RR; Sánchez LM; Alazzam A; Burnier JV; Stiharu I; Nerguizian V; 34577745
ENCS
9 Magnetic particle based liquid biopsy chip for isolation of extracellular vesicles and characterization by gene amplification Bathini S; Pakkiriswami S; Ouellette RJ; Ghosh A; Packirisamy M; 34517262
ENCS
10 Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery. Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG 33455300
CHEMBIOCHEM
11 Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles. Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG 31820915
CHEMBIOCHEM
12 One Cell, One Drop, One Click: Hybrid Microfluidics for Mammalian Single Cell Isolation. Samlali K, Ahmadi F, Quach ABV, Soffer G, Shih SCC 32705796
BIOLOGY
13 Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer. López RR, Ocampo I, Sánchez LM, Alazzam A, Bergeron KF, Camacho-León S, Mounier C, Stiharu I, Nerguizian V 32106424
ENCS
14 Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases. Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M 31817343
ENCS
15 Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels. Alazzam A, Al-Khaleel M, Riahi MK, Mathew B, Gawanmeh A, Nerguizian V 31394810
ENCS

 

Title:Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.
Authors:Huang Y,  Moini Jazani A,  Howell EP,  Oh JK,  Moffitt MG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31820915
DOI:10.1021/acsami.9b17101
Publication:ACS applied materials & interfaces
Keywords:directed self-assembly;  drug delivery;  microfluidics;  nanoparticles;  stimuli-responsive block copolymers; 
PMID:31820915 Category:ACS Appl Mater Interfaces Date Added:2020-09-24
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry , University of Victoria , PO Box 1700 Stn CSC, Victoria , BC V8W 2Y2 Canada.
2 Department of Chemistry and Biochemistry , Concordia University , 7141 Sherbrooke St. West , Montreal , Quebec H4B 1R6 , Canada.

Description:

Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

ACS Appl Mater Interfaces. 2020 Jan 08; 12(1):177-190

Authors: Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Abstract

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. On-chip self-assembly within a two-phase microfluidic reactor forms various "DualM" polymer nanoparticles (PNPs), including cylinders and multicompartment vesicles, with sizes and morphologies that are tunable with manufacturing flow rate. Complex kinetically trapped intermediates between shear-dependent states provide the most detailed mechanism to date of microfluidic PNP formation in the presence of flow-variable high shear. Glutathione (GSH)-triggered changes in PNP size and internal structure depend strongly on the initial flow-directed size and internal structure. Upon incubation in GSH, flow-directed PNPs with smaller average sizes showed a faster hydrodynamic size increase (attributed to junction cleavage) and those with higher excess Gibbs free energy showed faster inner compartment growth (attributed to pendant cleavage). These results demonstrate that the combination of chemical control of the location of biologically responsive linkages with microfluidic shear processing offers promising routes for tunable "smart" polymeric nanomedicines.

PMID: 31820915 [PubMed - indexed for MEDLINE]




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