PERFORM Publications

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Title		Authors	PubMed ID
1	Integrative approach to mitigate chromium toxicity in soil and enhance antioxidant activities in rice (Oryza sativa L.) using magnesium-iron nanocomposite and Staphylococcus aureus strains	Ali MA; Sardar MF; Dar AA; Niaz M; Ali J; Wang Q; Zheng Y; Luo Y; Albasher G; Li F;	39190219 ENCS
2	Synergistic Cathode Design for High-Performance Dual-Salt Magnesium/Lithium-Ion Batteries Using 2D/2D 1T/2H-MoS2@Ti3C2Tx MXene Nanocomposite	Rahmatinejad J; Liu X; Raisi B; Ye Z;	38698578 ENCS
3	Pillar-Structured Ti3 C2 Tx MXene with Engineered Interlayer Spacing for High-Performance Magnesium Batteries	Raisi B; Liu X; Rahmatinejad J; Ye Z;	38327158 ENCS
4	1T-2H Mixed-Phase MoS2 Stabilized with a Hyperbranched Polyethylene Ionomer for Mg2+ /Li+ Co-Intercalation Toward High-Capacity Dual-Salt Batteries	Rahmatinejad J; Raisi B; Liu X; Zhang X; Sadeghi Chevinli A; Yang L; Ye Z;	37691015 ENCS
5	Electrochemical nutrient removal from natural wastewater sources and its impact on water quality	Kékedy-Nagy L; English L; Anari Z; Abolhassani M; Pollet BG; Popp J; Greenlee LF;	34974342 CSFG
6	In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.	Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS	28476332 PERFORM

Title:	In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.
Authors:	Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28476332?dopt=Abstract
DOI:	10.1016/j.bcp.2017.04.031
Publication:	Biochemical pharmacology
Keywords:	5-Lipoxygenase products; 5-chloro-1-methyl-1H-indole-2-carbaldehyde (PubChem CID: 23004695); 5-oxo-ETE (PubChem CID: 5283159); 5S-HETE (PubChem CID: 5280733); BDMAEE (PubChem CID: 18204); BINOL (PubChem CID: 11762); Chiral analysis; Drug metabolism; Eicosanoids; Granulocytes; Inflammation; TBDMSCl (PubChem CID: 28928); indo-1 AM (PubChem CID: 123918); methyl 5-chloro-3-methyl-5-oxopentanoate (PubChem CID: 10888500); pentyl magnesium bromide (PubChem CID: 121513990); tBuOMe (PubChem CID: 15413);
PMID:	28476332	Category:	Biochem Pharmacol	Date Added:	2019-05-31
Dept Affiliation:	PERFORM 1 Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901-6982, USA. 2 Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1, Canada. 3 Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA. 4 Department of Chemistry and Biochemistry and PERFORM Centre, Concordia University, 7141 Sherbrooke St. W., Montréal, QC H4B 1R6, Canada. 5 Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1, Canada. Electronic address: william.powell@mcgill.ca.

Description:

In vivo a-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

Biochem Pharmacol. 2017 08 15;138:107-118

Authors: Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS

Abstract

We have developed a selective indole antagonist (230) targeting the OXE receptor for the potent eosinophil chemoattractant 5-oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid), that may be useful for the treatment of eosinophilic diseases such as asthma. In previous studies we identified ?2-oxidation of the hexyl side chain of racemic 230 as a major metabolic route in monkeys, but also obtained evidence for another pathway that appeared to involve hydroxylation of the hexyl side chain close to the indole. The present study was designed to investigate the metabolism of the active S-enantiomer of 230 (S230) and to identify the novel hydroxy metabolite and its chirality. Following oral administration, S230 rapidly appeared in the blood along with metabolites formed by a novel and highly stereospecific a-hydroxylation pathway, resulting in the formation of aS-hydroxy-S230. The chirality of a-hydroxy-S230 was determined by the total synthesis of the relevant diastereomers. Of the four possible diastereomers of a-hydroxy-230 only aS-hydroxy-S230 has significant OXE receptor antagonist activity and only this diastereomer was found in significant amounts in blood following oral administration of S230. Other novel metabolites of S230 identified in plasma by LC-MS/MS were aS,?2-dihydroxy-S230 and glucuronides of S230 and ?2-hydroxy-S230. Thus the alkyl side chain of S230, which is essential for its antagonist activity, is also the major target of the metabolic enzymes that terminate its antagonist activity. Modification of this side chain might result in the development of related antagonists with improved metabolic stability and efficacy.

PMID: 28476332 [PubMed - indexed for MEDLINE]

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