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PubMed Publications| Keyword search (4,164 papers available) |  |
"Infralimbic" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats | Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN; | 41372546 PSYCHOLOGY |
| 2 | Neural correlates of recall and extinction in a rat model of appetitive Pavlovian conditioning | Brown A; Villaruel FR; Chaudhri N; | 36496079 PSYCHOLOGY |
| 3 | The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands | Howland JG; Ito R; Lapish CC; Villaruel FR; | 35131398 PSYCHOLOGY |
| 4 | Corticostriatal suppression of appetitive Pavlovian conditioned responding | Villaruel FR; Martins M; Chaudhri N; | 34880119 PSYCHOLOGY |
| 5 | Different methods of fear reduction are supported by distinct cortical substrates. | Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD | 32589138 PSYCHOLOGY |
| Title: | The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands | ||||
| Authors: | Howland JG, Ito R, Lapish CC, Villaruel FR | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35131398/ | ||||
| DOI: | 10.1016/j.neubiorev.2022.104569 | ||||
| Publication: | Neuroscience and biobehavioral reviews | ||||
| Keywords: | Decision making; Dopamine; Dorsal striatum; Fear; Infralimbic; Nucleus accumbens; Prelimbic; Reward; Ventral striatum; | ||||
| PMID: | 35131398 | Category: | Date Added: | 2022-02-08 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Department of Anatomy, Physiology, and Pharmacology; University of Saskatchewan, Saskatoon, SK, Canada. Electronic address: john.howland@usask.ca. 2 Department of Psychology; University of Toronto - Scarborough, Toronto, ON, Canada. Electronic address: rutsuko.ito@utoronto.ca. 3 Department of Psychology; Indiana University - Purdue University Indianapolis, Indianapolis, IN, USA. Electronic address: clapish@iupui.edu. 4 Department of Psychology; Concordia University, Montreal, QC, Canada. Electronic address: fr.villaruel@gmail.com. |
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Description: |
Emerging evidence implicates rodent medial prefrontal cortex (mPFC) in tasks requiring adaptation of behavior to changing information from external and internal sources. However, the computations within mPFC and subsequent outputs that determine behavior are incompletely understood. We review the involvement of mPFC subregions, and their projections to the striatum and amygdala in two broad types of tasks in rodents: 1) appetitive and aversive Pavlovian and operant conditioning tasks that engage mPFC-striatum and mPFC-amygdala circuits, and 2) foraging-based tasks that require decision making to optimize reward. We find support for region-specific function of the mPFC, with dorsal mPFC and its projections to the dorsomedial striatum supporting action control with higher cognitive demands, and ventral mPFC engagement in translating affective signals into behavior via discrete projections to the ventral striatum and amygdala. However, we also propose that defined mPFC subdivisions operate as a functional continuum rather than segregated functional units, with crosstalk that allows distinct subregion-specific inputs (e.g., internal, affective) to influence adaptive behavior supported by other subregions. |
